6533b7d8fe1ef96bd126a586
RESEARCH PRODUCT
Hemin induces germ tube formation in Candida albicans.
José P. MartínezManuel CasanovaAna M. CerveraDaniel Gozalbosubject
Cellular differentiationImmunologyGerm tubeBiologyMicrobiologyBlastoconidiumMicrobiologyAcetylglucosaminechemistry.chemical_compoundCandida albicansInducerDrug InteractionsCandida albicansDose-Response Relationship DrugCell DifferentiationSpores Fungalbiology.organism_classificationYeastCorpus albicansInfectious DiseasesGlucosechemistryHeminParasitologyHeminResearch Articledescription
Hemin induced germination of Candida albicans blastoconidia when cells grown up to the early exponential phase were shifted from 28 to 37 degrees C (70 to 75% of cells exhibited germ tubes). N-Acetyl-D-glucosamine (GlcNAc), another inducer of myceliation in this fungus, caused a similar effect. The combination of hemin and GlcNAc resulted in a higher percentage (95%) of blastoconidial germination. These results suggest that in addition to temperature, hemin levels and carbon source may coordinately regulate the expression of subsets of genes involved in the yeast-to-mycelium transition in C. albicans.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-10-01 | Infection and immunity |