Search results for "Hep"
showing 10 items of 12243 documents
Predominance of Type 1 Innate Lymphoid Cells in the Rectal Mucosa of Patients With Non-Celiac Wheat Sensitivity: Reversal After a Wheat-Free Diet.
2016
OBJECTIVES: Non-celiac wheat sensitivity (NCWS) is defined as a reaction to ingested wheat after exclusion of celiac disease and wheat allergy. As its pathogenesis is incompletely understood, we evaluated the inflammatory response in the rectal mucosa of patients with well-defined NCWS. METHODS: The prospective study included 22 patients with irritable bowel syndrome (IBS)-like clinical presentation, diagnosed with NCWS by double-blind placebo-controlled challenge. Eight IBS patients not improving on wheat-free diet were used as controls. Two weeks after oral challenge was performed with 80 grams of wheat daily, cells were isolated from rectal biopsies and thoroughly characterized by fluore…
The XENON1T Dark Matter Experiment
2017
The XENON1T experiment at the Laboratori Nazionali del Gran Sasso (LNGS) is the first WIMP dark matter detector operating with a liquid xenon target mass above the ton-scale. Out of its 3.2 t liquid xenon inventory, 2.0 t constitute the active target of the dual-phase time projection chamber. The scintillation and ionization signals from particle interactions are detected with low-background photomultipliers. This article describes the XENON1T instrument and its subsystems as well as strategies to achieve an unprecedented low background level. First results on the detector response and the performance of the subsystems are also presented. © 2017, The Author(s).
Search for inelastic scattering of WIMP dark matter in XENON1T
2021
We report the results of a search for the inelastic scattering of weakly interacting massive particles (WIMPs) in the XENON1T dark matter experiment. Scattering off $^{129}$Xe is the most sensitive probe of inelastic WIMP interactions, with a signature of a 39.6 keV de-excitation photon detected simultaneously with the nuclear recoil. Using an exposure of 0.89 tonne-years, we find no evidence of inelastic WIMP scattering with a significance of more than 2$\sigma$. A profile-likelihood ratio analysis is used to set upper limits on the cross-section of WIMP-nucleus interactions. We exclude new parameter space for WIMPs heavier than 100 GeV/c${}^2$, with the strongest upper limit of $3.3 \time…
Search for Light Dark Matter Interactions Enhanced by the Migdal Effect or Bremsstrahlung in XENON1T.
2019
Direct dark matter detection experiments based on a liquid xenon target are leading the search for dark matter particles with masses above ∼5 GeV/c2, but have limited sensitivity to lighter masses because of the small momentum transfer in dark matter-nucleus elastic scattering. However, there is an irreducible contribution from inelastic processes accompanying the elastic scattering, which leads to the excitation and ionization of the recoiling atom (the Migdal effect) or the emission of a bremsstrahlung photon. In this Letter, we report on a probe of low-mass dark matter with masses down to about 85 MeV/c2 by looking for electronic recoils induced by the Migdal effect and bremsstrahlung us…
XENON1T Dark Matter Data Analysis: Signal Reconstruction, Calibration and Event Selection
2019
The XENON1T experiment at the Laboratori Nazionali del Gran Sasso is the most sensitive direct detection experiment for dark matter in the form of weakly interacting particles (WIMPs) with masses above $6\,$GeV/$c^2$ scattering off nuclei. The detector employs a dual-phase time projection chamber with 2.0 metric tons of liquid xenon in the target. A one metric $\mathrm{ton}\times\mathrm{year}$ exposure of science data was collected between October 2016 and February 2018. This article reports on the performance of the detector during this period and describes details of the data analysis that led to the most stringent exclusion limits on various WIMP-nucleon interaction models to date. In pa…
Excess electronic recoil events in XENON1T
2020
We report results from searches for new physics with low-energy electronic recoil data recorded with the XENON1T detector. With an exposure of 0.65 t-y and an unprecedentedly low background rate of $76\pm2$ events/(t y keV) between 1 and 30 keV, the data enables sensitive searches for solar axions, an enhanced neutrino magnetic moment, and bosonic dark matter. An excess over known backgrounds is observed at low energies and most prominent between 2 and 3 keV. The solar axion model has a 3.4$\sigma$ significance, and a 3D 90% confidence surface is reported for axion couplings to electrons, photons, and nucleons. This surface is inscribed in the cuboid defined by $g_{ae}<3.8 \times 10^{-12}$,…
Effects of Zoledronic Acid on Cathepsin K circulating levels in patients with bone metastasis.
2007
Cathepsin K serum levels were determinated in patients with bone metastases from breast cancer or prostate cancer in therapy with zoledronic acid or in patients or in patients with located breast or prostate cancer end in patients with non malignant diseases and in healthy blood. donors (control group). Cathepsin K serum levels were significantly more eleved in healthy subjects or in patients with peimary osteoporosis. Furthermore, the administration of Zoledronic acid to patients with metastatic bome disease from breast or prostate cancer, induced a marked increase of Cathepsin K serum levels.
Intraocular pressure and central corneal thickness in an old French population: The MONTRACHET study
2013
Purpose: To describe the distribution of intraocular pressure (IOP) and central corneal thickness (CCT) in an old French population. Methods: About 9000 individuals 65 years and older were included in the 3C cohort study since 1999 in 3 French cities (Bordeaux, Dijon and Montpellier). In Dijon, an additional ophthalmic examination was performed 10 years after the initial inclusions to assess the relation between systemic age-related diseases and eye diseases in the MONTRACHET Study (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases). In this population-based stuy a thorough eye examination and a questionnaire were undertaken in each participant. Intraocular pressure (IOP) w…
Hepcidīna korelācija ar iekaisīgu zarnu slimību aktivitāti
2022
Ievads: Čūlains kolīts un Krona slimība ir multifaktorialās slimības. Zinot slimības patoģenēzi un slimības biežākas komplikācijas, var pietuvoties pareizai un mērķtiecīgai slimības diagnostikai. Šobrīd ir aktuāli un nepieciešams noteikt precīzu, minimāli invazīvu biomarķieri vai laboratorijas rādītāju kuru, kombinējot ar citiem jau zināmiem minimāli invazīviem IZS laboratorijas rādītājiem, būs iespējams agrīni prognozēt slimības aktivitāti, novērst paasinājumu un iespējams komplikāciju attīstību. Darba mērķis: Noteikt hepcidīna korelāciju ar citiem slimības aktivitātes mārķieriem (CRO, kalprotektīns, feritīns) pacientiem ar IZS. Materiāli un metodes: Tas ir prospektīvs pētījums, kas veikts…
Hroniska C hepatīta ārstēšanas efektivitāte ar tiešās darbības antivirālajiem medikamentiem: reālas dzīves dati
2017
Darba aktualitāte: Hronisks C hepatīts ir globāla problēma jau daudzus gadus. Slimības sākuma stadijā parasti nav simptomu. Pēdējo dažu gadu laikā hroniska C hepatīta ārstēšana ir būtiski izmainījusies un ar jauno medikamentu palīdzību ir iespēja pilnībā izārstēties. Jaunais ārstēšanas kurss ir īsāks, labi panesams un ir augsta efektivitāte. Darba mērkis: Izvērtēt tiešās darbības antivirālo medikamentu efektivitāti un ieguvumus Latvijā. Metodes un materiāli: Tika veikts retrospektīvs pētījums, apkopota informācija no pacientu ambulatorajām kartēm, kuras tika ņemtas no Latvijas Infektoloģijas centra. Pētījumam tik atlasīti pacienti, kuriem ir diagnoze “Hronisks C hepatīts” un kuri ārstēšanā …