Search results for "Highlight"

showing 10 items of 52 documents

In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges

2020

Flexible spikes The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein enables viral entry into host cells by binding to the angiotensin-converting enzyme 2 (ACE2) receptor and is a major target for neutralizing antibodies. About 20 to 40 spikes decorate the surface of virions. Turoňová et al. now show that the spike is flexibly connected to the viral surface by three hinges that are well protected by glycosylation sites. The flexibility imparted by these hinges may explain how multiple spikes act in concert to engage onto the flat surface of a host cell. Science, this issue p. 203

In situElectron Microscope TomographyGlycanGlycosylationFlexibility (anatomy)virusesProtein domainPneumonia ViralHingeMolecular Dynamics SimulationBiologylaw.inventionBetacoronavirusProtein DomainslawTarget identificationmedicineHumansPandemicsResearch ArticlesHost cell surfaceMultidisciplinarySARS-CoV-2R-ArticlesCryoelectron MicroscopyBiochemCOVID-19MicrobioResearch HighlightCell biologymedicine.anatomical_structureSpike Glycoprotein Coronavirusbiology.proteinRecombinant DNASpike (software development)Protein MultimerizationStructural biologyCoronavirus InfectionsResearch ArticleScience (New York, N.y.)
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Diabetic foot syndrome: Immune-inflammatory features as possible cardiovascular markers in diabetes

2015

Diabetic foot ulcerations have been extensively reported as vascular complications of diabetes mellitus associated with a high degree of morbidity and mortality. Diabetic foot syndrome (DFS), as defined by the World Health Organization, is an "ulceration of the foot (distally from the ankle and including the ankle) associated with neuropathy and different grades of ischemia and infection". Pathogenic events able to cause diabetic foot ulcers are multifactorial. Among the commonest causes of this pathogenic pathway it's possible to consider peripheral neuropathy, foot deformity, abnormal foot pressures, abnormal joint mobility, trauma, peripheral artery disease. Several studies reported how …

Inflammationmedicine.medical_specialtyPathologySettore MED/09 - Medicina InternaDiabetic foot syndrome; Inflammation; Cytokines; Cardiovascular risk; Markerbusiness.industryType 2 Diabetes MellitusType 2 diabetesDiseaseDiabetic foot syndromeMarkerCardiovascular riskmedicine.diseaseDiabetic footInsulin resistancePeripheral neuropathyInternal medicineDiabetes mellitusmedicineOrthopedics and Sports MedicineTopic HighlightbusinessCytokineFoot deformityWorld Journal of Orthopedics
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Nanotechnology applications for the therapy of liver fibrosis.

2013

Chronic liver diseases represent a major global health problem both for their high prevalence worldwide and, in the more advanced stages, for the limited available curative treatment options. In fact, when lesions of different etiologies chronically affect the liver, triggering the fibrogenesis mechanisms, damage has already occurred and the progression of fibrosis will have a major clinical impact entailing severe complications, expensive treatments and death in end-stage liver disease. Despite significant advances in the understanding of the mechanisms of liver fibrinogenesis, the drugs used in liver fibrosis treatment still have a limited therapeutic effect. Many drugs showing potent ant…

Liver CirrhosisSettore MED/09 - Medicina InternaAntifibrotic drugs CirrhosiLiver fibrosisChemistry PharmaceuticalLiver fibrosisCellPharmacologyBioinformaticsAntifibrotic drugsLiver diseaseNanoparticleHepatic stellate cellsIn vivoFibrosisMedicineNanotechnologyAnimalsHumansTopic HighlightAdverse effectHepatic stellate cellDrug Carriersbusiness.industryTherapeutic effectGastroenterologyLiver fibrosiGeneral Medicinemedicine.diseasemedicine.anatomical_structureNanomedicineTreatment OutcomeCirrhosisHepatic stellate cellNanoparticlesbusinessWorld journal of gastroenterology
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Genetic association of interleukin-6 polymorphism (-174 G/C) with chronic liver diseases and hepatocellular carcinoma

2012

Interleukin-6 (IL-6) is a pleiotropic cytokine which is expressed in many inflammatory cells in response to different types of stimuli, regulating a number of biological processes. The IL-6 gene is polymorphic in both the 5’ and 3’ flanking regions and more than 150 single nucleotide polymorphisms have been identified so far. Genetic polymorphisms of IL-6 may affect the outcomes of several diseases, where the presence of high levels of circulating IL-6 have been correlated to the stage and/or the progression of the disease itself. The -174 G/C polymorphism is a frequent polymorphism, that is located in the upstream regulatory region of the IL-6 gene and affects IL-6 production. However, the…

Liver Cirrhosismedicine.medical_specialtyCarcinoma HepatocellularHepatitis C virusSingle-nucleotide polymorphismBiologyChronic liver diseasemedicine.disease_causePolymorphism Single NucleotideGastroenterologyHepatitis B ChronicNon-alcoholic Fatty Liver DiseaseRisk FactorsChronic hepatitis Hepatocellular carcinoma Interleukin-6 Liver cirrhosis Single nucleotide polymorphismsInternal medicineGenotypemedicineHumansGenetic Predisposition to DiseaseTopic HighlightLiver Diseases AlcoholicInterleukin-6Liver NeoplasmsFatty liverGastroenterologyGeneral MedicineHepatitis C ChronicHepatitis Bmedicine.diseaseFatty LiverHepatitis AutoimmunePhenotypeHepatocellular carcinomaImmunologySteatohepatitisWorld Journal of Gastroenterology
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Treatment of COVID-19 with MSCs: how does it work?

2021

The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells (MSCs) potentially improves clinical symptoms, but the underlying mechanism remains unclear. We conducted a randomized, single-blind, placebo-controlled (29 patients/group) phase II clinical trial to validate previous findings and explore the potential mechanisms. Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay (P = 0.0198) and less time required for symptoms remission (P = 0.0194) than those who received placebo. Based on chest images, both severe and critical patients treated with MSCs showed improvement by day 7 (P = 0.0099) and day 21 (P = 0.0084). MSC-treated pat…

Male2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)T-LymphocytesB-Lymphocyte SubsetsAntibodies ViralMesenchymal Stem Cell TransplantationExtracellular TrapsGeneral Biochemistry Genetics and Molecular BiologyArticleImmunomodulationMiceMedicineAnimalsHumansGeneral Environmental ScienceAgedVenous Thrombosisbusiness.industrySARS-CoV-2Mesenchymal stem cellCOVID-19Middle AgedVirologyResearch HighlightMice Inbred C57BLCytoskeletal ProteinsDisease Models AnimalMechanisms of diseaseC-Reactive ProteinWork (electrical)Leukocytes MononuclearMesenchymal stem cellsCytokinesFemaleGeneral Agricultural and Biological SciencesbusinessScience China. Life Sciences
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Functional characterization of the dural sinuses as a neuroimmune interface

2021

Summary Despite the established dogma of central nervous system (CNS) immune privilege, neuroimmune interactions play an active role in diverse neurological disorders. However, the precise mechanisms underlying CNS immune surveillance remain elusive; particularly, the anatomical sites where peripheral adaptive immunity can sample CNS-derived antigens and the cellular and molecular mediators orchestrating this surveillance. Here, we demonstrate that CNS-derived antigens in the cerebrospinal fluid (CSF) accumulate around the dural sinuses, are captured by local antigen-presenting cells, and are presented to patrolling T cells. This surveillance is enabled by endothelial and mural cells formin…

MaleT-LymphocytesDura materCentral nervous systemAntigen-Presenting CellsCranial SinusesBiologyGeneral Biochemistry Genetics and Molecular BiologyMural cell03 medical and health sciences0302 clinical medicineImmune privilegemedicineAnimalsHomeostasisHumansAntigensCellular Senescence030304 developmental biologyAntigen Presentation0303 health sciencesMultiple sclerosisImmunityMeningesmedicine.diseaseAcquired immune systemResearch HighlightChemokine CXCL12Mice Inbred C57BLPhenotypeNeuroimmunologymedicine.anatomical_structureFemaleDura MaterStromal CellsNeuroscience030217 neurology & neurosurgeryCell
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L’inclusione vista dagli alunni: costruzione e validazione del questionario per rilevare la qualità inclusiva della scuola

2018

Molti studi nazionali e internazionali si sono concentrati sulla valutazione e sulla promozione della qualità inclusiva della scuola. Si tratta di un argomento complesso, che ha stimolato un ampio dibattito e una varietà di contributi che mettono in luce la necessità di uno strumento in grado di misurare la qualità inclusiva delle nostre scuole, per determinare l’evidenza empirica riguardo a questo tema. L’articolo presenta i risultati di una sperimentazione finalizzata alla redazione di un questionario per la rilevazione della qualità inclusiva del sistema scolastico percepita dagli alunni. Il questionario si pone come uno strumento di valutazione e autovalutazione che permette la misurazi…

Many national and international studies have concentrated on the evaluation and promotion of the inclusive qualities of schools. It is a complex issue which has led to wide debate and a variety of contributions which in turn highlight the need for a tool capable of measuring the inclusive quality of our schools in order to determine the empirical evidence regarding this topic. This article presents the results of an experiment in drafting a questionnaire in order to measure the inclusive quality of the school system perceived by its pupils. The questionnaire is intended as an evaluation and selfevaluation tool that enables the inclusive quality generated by the context to be measured as it is perceived by pupils. At the same time the tool allows reflection processes amongst teachers to be promoted so that they can implement educational activities which contribute to the planning and control of inclusive teaching practices. This contribution puts forward an original tool for measuring the inclusive quality of the school system perceived by pupils attending primary school in several Sicilian towns. It was administered in its definitive version to a sample of 1652 children. The psychometric properties of the tool and the significance it can hold in the areas of planning in research and of educational design are presented in this paper.Settore M-PED/03 - Didattica E Pedagogia Speciale
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Viaggi nell’immaginario: il turismo virtuale nel sito UNESCO di Tarragona

2023

Le nuove tecnologie hanno trasformato in modo radicale non solo la geografia come disciplina, ma anche le geografie del mondo. Il digitale ha assunto, infatti, un ruolo di mediazione sempre più pervasivo nella produzione dello spazio, come delle conoscenze e degli immaginari geografici. Le possibilità offerte dal virtuale, in particolare, offrono oggi un contributo decisivo nella comunicazione dei significati attribuiti ai luoghi e rispondono in modo sempre più efficace ai bisogni emergenti del settore turistico. Le esperienze di visita mediate dal digitale mirano a coinvolgere i sensi e risultano efficaci quando promuovono immersioni rigorosamente realistiche. Nel quadro di queste riflessi…

New technologies have radically transformed not only geography as a discipline but also the geographies of the world. Indeed the digital has assumed an increasingly pervasive mediating role in the production of space as of geographic knowledge and imaginaries. The possibilities offered by the virtual in particular now offer a decisive contribution in communicating the meanings attributed to places and respond increasingly effectively to the emerging needs of the tourism sector. Digitally mediated visitor experiences aim to engage the senses and are effective when they promote rigorously realistic immersions. Within the framework of these reflections the paper highlights the renewed relevance of authenticity both of the tourism experience and of cultural heritage in relation to its potential for attraction and proposes a contextualization of the theme in light of the unprecedented opportunities granted by technologies for the creation of virtual and augmented spaces. The proposed discussion is therefore also a journey aimed at exploring authenticity as a tool through which new technologies can effectively mediate a sense of place and foster brand communication of a destination. The case study is the UNESCO site of Tarragona whose most relevant image for urban policies is presented. This shared figuration spatially defined and rooted in a precise historical moment is reconstructed on the one hand through the analysis of functional documentation for the candidacy and on the other by means of a review of mobile applications developed for the promotion of the city's cultural heritage. The proposed journey and exploration of the place return in light of the research data and in conclusion the central role played by digital technologies in mediating the UNESCO imaginary. The forms of virtual tourism in Tarragona confirm that to travel is to experience a text enveloped in time and inscribed in space.Settore M-GGR/01 - Geografia
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Staging systems of hepatocellular carcinoma: A review of literature

2013

Hepatocellular carcinoma (HCC) is a major health problem with a high incidence and mortality all over the world. Natural history of HCC is severe and extremely variable, and prognostic factors influencing outcomes are incompletely defined. Over time, many staging and scoring systems have been proposed for the classification and prognosis of patients with HCC. Currently, the non-ideal predictive performance of existing prognostic systems is secondary to their inherent limitations, as well as to a non-universal reproducibility and transportability of the results in different populations. New serological and histological markers are still under evaluation with promising results, but they requi…

Oncologymedicine.medical_specialtyAsiaCarcinoma HepatocellularTime FactorsMedical OncologyGastroenterologyInternal medicineBiomarkers TumorHumansMedicineTopic HighlightNeoplasm Stagingbusiness.industryIncidence (epidemiology)Liver NeoplasmsGastroenterologyExternal validationReproducibility of ResultsGeneral MedicinePrognosismedicine.diseasedigestive system diseasesEuropeNatural historyHepatocellular carcinomabusinessAlgorithmsWorld Journal of Gastroenterology
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Peritoneal carcinosis of ovarian origin

2010

Epithelial ovarian cancer (EOC) is the second most common genital malignancy in women and is the most lethal gynecological malignancy, with an estimated five-year survival rate of 39%. Despite efforts to develop an effective ovarian cancer screening method, 60% of patients still present with advanced disease. Comprehensive management using surgical cytoreduction to decrease the tumor load to a minimum, and intraperitoneal chemotherapy to eliminate microscopic disease on peritoneal surface, has the potential to greatly improve quality of life and to have an impact on survival in ovarian cancer patients. Despite achieving clinical remission after completion of initial treatment, most patients…

Oncologymedicine.medical_specialtyendocrine system diseasesbusiness.industryPeritoneal carcinosisGastroenterologyDrug resistancemedicine.diseaseMalignancySettore MED/40 - Ginecologia E Ostetriciafemale genital diseases and pregnancy complicationsSurgeryCytoreductionOvarian cancer Intraperitoneal hyperthermic chemotherapyOncologyQuality of lifePeritoneal carcinosiInternal medicinemedicineSex organTopic HighlightOvarian cancerbusinessSurvival rateTumor LoadWorld Journal of Gastrointestinal Oncology
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