Search results for "Histamine"

In vitro pharmacological evaluation of the dichloromethanol extract fromSchinus molle l.

1998

The pharmacological activity of the dichloromethanol extract of Schinus molle L. (SM-DCM) was analysed in in vitro models. Preincubation of the isolated guinea-pig ileum or rat uterus preparations with the extract (100 μg/mL) abolished the contractile effects of histamine and serotonin respectively. At the same dose, the extract partially reduced the contractile effects of acetylcholine on the isolated rat duodenum. A 10 μg/mL dose showed an inhibitory effect on histamine and serotonin, but not on acetylcholine-induced contractions (NS). No significant effect was found with a 1 μg/mL dose. © 1998 John Wiley & Sons, Ltd.

Gastric histamine methyltransferase: Different methylation rates for enantiomers of side-chain methylated histamine analogues using a highly purified…

1984

The inhibitor/activator and substrate properties of enantiomers of two methylated histamines (MH) were investigated using a histamine methyltransferase preparation which was purified 1207-fold from pig fundic mucosa by ultracentrifugation, ion-exchange chromatography on DEAE-cellulose and preparative electrofocusing. In 1-100 microM concentrations, S-alpha-MH and R-alpha-MH were acceptor substrates as good as histamine itself. When substrate concentrations were increased to 1 mM these substances were methylated to an even greater extent than histamine, since they did not exert substrate inhibition on HMT. Introduction of a further methyl-group into the N alpha-position reduced acceptor subs…

Effects of GABA on hypothalamic histamine neurons in vitro

1990

�ber die Rolle des Histamins bei der Verk�rzung der Blutungszeit nach Adrenalin

1955

Die Verkurzung der Blutungszeit nach Adrenalin konnte durch die Antihistaminica Casantin oder Luvistin sowohl aufgehoben als auch verhindert werden. Die Versuche sprechen dafur, das Histamin an der Verkurzung der Blutungszeit nach Adrenalin wesentlich beteiligt ist.

Histamine release during induction of anaesthesia and preparation for operation in patients undergoing general surgery: Incidence and clinically seve…

1992

Histamine release events were shown in a prospective randomized controlled trial in patients undergoing elective general surgery with an extraordinarily high incidence: 73 per cent. This high incidence was explained by several factors: — the sample size which was much greater than in previous studies — the improved plasma histamine assay — the precise definition of histamine release in clinical conditions and its measurement at the top of Bateman functions — the standardized induction of anaesthesia and preparation of the surgical patient — and finally the considerable number of cancer patients since more than 60% of the reactions >5 ng/ml occurred in this group which comprised only 20% of …

Comparison of roxatidine and ranitidine in the treatment of refractory duodenal ulcer

1994

Abstract Fourteen patients with duodenal ulcer not healed after treatment with ranitidine at the standard dosage of 300 mg/day for 12 weeks were enrolled in the study. Eight patients were treated with roxatidine acetate, 150 mg/day, for 8 weeks (group A); six patients received treatment with ranitidine, 600 mg/day, for 8 weeks (group B). Efficacy of treatment was evaluated on the basis of reduction of ulcer pain, lowering of maximal acid output (MAO) levels, and cicatrization of ulcer lesion. The patients treated with roxatidine showed a significant reduction in MAO levels after 4 weeks, whereas the patients treated with ranitidine showed a significant reduction in MAO levels after 8 weeks.…

Histamine inhibits spontaneous activity of the uterus of the progesterone-treated rat

1993

�ber Histamin als Mittlersubstanz bei der Wirkung von Adrenochrom als Aktivator von Reticuloendothelzellen

1955

In Bestatigung der Befunde von Jansco zeigt sich, das nach intracutaner Injektion von 25–50 γ Histamin in die Bauchhaut von Ratten eine Aktivierung des Gefasendothels eintritt. Intravenos injizierte Tusche wird von den Gefasendothelien an der Injektionsstelle des Histamins gespeichert.

Bronchodilator and anti-inflammatory activities of glaucine:In vitrostudies in human airway smooth muscle and polymorphonuclear leukocytes

1999

Selective phosphodiesterase 4 (PDE4) inhibitors are of potential interest in the treatment of asthma. We examined the effects of the alkaloid S-(+)-glaucine, a PDE4 inhibitor, on human isolated bronchus and granulocyte function. Glaucine selectively inhibited PDE4 from human bronchus and polymorphonuclear leukocytes (PMN) in a non-competitive manner (Ki=3.4 μM). Glaucine displaced [3H]-rolipram from its high-affinity binding sites in rat brain cortex membranes (IC50∼100 μM). Glaucine inhibited the spontaneous and histamine-induced tone in human isolated bronchus (pD2∼4.5). Glaucine (10 μM) did not potentiate the isoprenaline-induced relaxation but augmented cyclic AMP accumulation by isopre…

Globularia alypumL. extracts reduced histamine and serotonin contractionin vitro

2002

The present study analyses in in vitro models the pharmacological activity of methanol and dichloromethane extracts (1, 10 and 100 microg/mL) obtained from the leaves and stems of Globularia alypum L. Preincubation of the guinea-pig ileum and rat uterus with both extracts produced a dose dependent abolition of the contractile effects of histamine and serotonin, respectively. At the same doses, neither methanol nor dichloromethane extract reduced the contractile effects of acetylcholine on rat duodenum or noradrenaline on rat vas deferens.