Search results for "Hydroquinones"

showing 3 items of 13 documents

Induction of micronuclei in V79 Chinese hamster cells by tetrachlorohydroquinone, a metabolite of pentachlorophenol

1992

Tetrachlorohydroquinone, a metabolite of the fungicide pentachlorophenol, induced significant dose-related increases in micronuclei in V79 Chinese hamster cells without exogenous metabolic activation. The lowest observed effective dose was 10 microM, where the relative survival was about 62%. At the highest dose tested, 20 microM, the relative survival was about 8% and the frequency of cells with micronuclei was about 6 times the solvent control frequency. The induction of micronuclei by tetrachlorohydroquinone was significantly inhibited by the hydroxyl radical scavenger dimethyl sulfoxide at 5% (v/v).

PentachlorophenolMetaboliteHamsterToxicologycomplex mixturesChinese hamsterchemistry.chemical_compoundCricetulusCricetinaeGeneticsAnimalsDimethyl SulfoxideCells CulturedMicronuclei Chromosome-DefectiveCarcinogenMicronucleus TestsbiologyDimethyl sulfoxidebiology.organism_classificationMolecular biologyEffective dose (pharmacology)HydroquinonesPentachlorophenolchemistryBiochemistryMicronucleus testDNA DamageMutation Research/Genetic Toxicology
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Quinol sulphate, a new conjugate of phenol in goldfish.

1983

1. Metabolism of phenol in goldfish yielded the known phenyl conjugates in fish--phenyl sulphate and phenyl glucuronide. Additionally, quinol sulphate, a new conjugate of phenol in fish, was detected.

PharmacologyPhenolChemistryHealth Toxicology and MutagenesisCyprinidaemacromolecular substancesGeneral MedicineMetabolismToxicologyBiochemistryHydroquinoneschemistry.chemical_compoundPhenolsGoldfishOrganic chemistryFish <Actinopterygii>PhenolAnimalssense organsChromatography Thin LayerGlucuronideChromatography High Pressure LiquidConjugateXenobiotica; the fate of foreign compounds in biological systems
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Hydroxylation and conjugation of phenol by the frog Rana temporaria.

1985

1. Frogs injected with phenol excrete 67–95% of dose in 15h; 32–87% of dose are metabolites.2. Metabolites identified were phenyl sulphate (15–44% of dose), phenyl glucuronide (10–25% of dose), catechol sulphate (up to 7% of dose), quinol sulphate (1–25% of dose), resorcinol and catechol (traces).

StereochemistryHealth Toxicology and MutagenesisRana temporariaCatecholsGlucuronatesResorcinolSulfuric Acid EstersToxicologyHydroxylationBiochemistryHydroxylationchemistry.chemical_compoundPhenolsSalientiaPhenolAnimalsCarbon RadioisotopesChromatography High Pressure LiquidPharmacologyCatecholChromatographybiologyPhenolGeneral MedicineMetabolismResorcinolsbiology.organism_classificationHydroquinoneschemistryGRENOUILLEGlucuronideXenobiotica; the fate of foreign compounds in biological systems
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