Search results for "Ión"
showing 10 items of 13543 documents
Ethanol-Induced Oxidative Stress Modifies Inflammation and Angiogenesis Biomarkers in Retinal Pigment Epithelial Cells (ARPE-19): Role of CYP2E1 and …
2020
The retinal pigment epithelium (RPE) plays a key role in retinal health, being essential for the protection against reactive oxygen species (ROS). Nevertheless, excessive oxidative stress can induce RPE dysfunction, promoting visual loss. Our aim is to clarify the possible implication of CYP2E1 in ethanol (EtOH)-induced oxidative stress in RPE alterations. Despite the increase in the levels of ROS, measured by fluorescence probes, the RPE cells exposed to the lowest EtOH concentrations were able to maintain cell survival, measured by the Cell Proliferation Kit II (XTT). However, EtOH-induced oxidative stress modified inflammation and angiogenesis biomarkers, analyzed by proteome array, ELIS…
Filosofía, ciencia y biología sintética
2016
En este artículo se defiende la necesidad de que el actor de la ciencia, el científico, disponga de suficiente formación filosófica como para analizar críticamente el alcance de su propia actividad especializada, análisis que debiera empezar por entender qué es eso a lo que llamamos ciencia. Se ejemplifica la necesidad de tal formación recurriendo a la biología sintética. Se muestran los peligros que se corren de la derivación hacia campos no científicos si el científico está imbuido de una ciencia fáustica orientada a la obtención del producto –el ente biológico sintético– disminuyendo veladamente el interés por estudiar el mismo desde la óptica de la ciencia prometeica, aquella que se apr…
Identification and visualization of differential isoform expression in RNA-seq time series
2018
Abstract Motivation As sequencing technologies improve their capacity to detect distinct transcripts of the same gene and to address complex experimental designs such as longitudinal studies, there is a need to develop statistical methods for the analysis of isoform expression changes in time series data. Results Iso-maSigPro is a new functionality of the R package maSigPro for transcriptomics time series data analysis. Iso-maSigPro identifies genes with a differential isoform usage across time. The package also includes new clustering and visualization functions that allow grouping of genes with similar expression patterns at the isoform level, as well as those genes with a shift in major …
Validación del cribado nutricional Malnutrition Screening Tool comparado con la valoración nutricional completa y otros cribados en distintos ámbitos…
2018
Resumen Introducción: los cribados son empleados para detectar el riesgo nutricional y permiten intervenir precozmente e influir en el pronóstico. La herramienta Malnutrition Screening Tool (MST) está validada en paciente hospitalizado y oncológico ambulatorio. Objetivo: analizar por ámbitos sociosanitarios y grupos etarios los cribados MST, Malnutrition Universal Screening Tool (MUST) y Mini Nutritional Assessment-Short Form (MNA-sf) respecto a la valoración nutricional completa (VNC) como patrón de referencia, y evaluar la utilidad del MST en aquellos ámbitos donde no está validado. Material y métodos: se han incluido 815 sujetos ambulatorios, hospitalizados e institucionalizados. Se les …
Vitamin D and Cardiovascular Health
2021
The principal source of vitamin D in humans is its biosynthesis in the skin through a chemical reaction dependent on sun exposure. In lesser amounts, the vitamin can be obtained from the diet, mostly from fatty fish, fish liver oil and mushrooms. Individuals with vitamin D deficiency, defined as a serum level of 25 hydroxyvitamin D < 20 ng/dl, should be supplemented. Vitamin D deficiency is a prevalent global problem caused mainly by low exposure to sunlight. The main role of 1,25 dihydroxyvitamin D is the maintenance of calcium and phosphorus homeostasis. However, vitamin D receptors are found in most human cells and tissues, indicating many extra-skeletal effects of the vitamin, particula…
Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy
2019
Radiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation also causes detrimental effects in the healthy tissue, leading to neurocognitive sequelae that compromise the quality of life of brain cancer patients. Despite the recognition of this serious complication, no satisfactory solutions exist at present. Here we investigated the effects of intranasal administration of human mesenchymal stem cells (hMSCs) as a neuroprotective strategy for cranial radiation in mice. Our results demonstrated that intranasally delivered hMSCs promote radiation-induced brain injury repair, improving neurological function. This intervention confers protection against inflamma…
Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders
2015
The pathogen safety of blood/plasma-derived products has historically been a subject of significant concern to the medical community, Measures such as donor selection and blood screening have contributed to increase the safety of these products, but pathogen transmission does still occur. Reasons for this include lack of sensitivity/specificity of current screening methods, lack of reliable screening tests for some pathogens (e.g. prions) and the fact that many potentially harmful infectious agents are not routinely screened for. Methods for the purification/inactivation of blood/plasma-derived products have been developed in order to further reduce the residual risk, but low concentrations…
Validation of the Satisfaction Questionnaire with physical education classes (CSCEF) in the Latin American context
2020
The objective of this study was to validate the Satisfaction Questionnaire in Physical Education Classes (CSCEF) in the context of Latin America (Dominican Republic). 1298 students aged between 15 and 21 participated. The psychometric properties of the instrument were analysed. The results demonstrated that the best factor solution would be a multidimensional model represented by nine dimensions for the satisfaction construct, as well as a higher-order model. According to Cronbach's alpha and omega index, values between .66 and .99 were obtained. The Latin American version of the CSCEF was invariant with respect to gender. Although the results of this study support the validity and reliabil…
Contenidos fundamentales de la Dermatología en el grado de medicina en España. Recomendaciones del grupo de profesores de la Academia Española de Der…
2016
Antecedentes: Los problemas dermatologicos constituyen uno de los motivos de consulta masfrecuentes en atencion primaria. En los ultimos a˜nos, como consecuencia de la adaptacion alespacio europeo de educacion superior, en muchos planes de estudios se ha reducido el tiempodestinado al aprendizaje de la dermatologia.Material y metodos:Para consensuar los contenidos basicos del programa de dermatologia enel pregrado, se remitio electronicamente una encuesta a los 57 miembros de grupo de profeso-res de la Academia Espa˜nola de Dermatologia y Venereologia para establecer cuales deberianser los objetivos de aprendizaje de la asignatura en Espa˜na. Se incluyeron 131 objetivos previa-mente selecci…
Artroplastia de suspensión dinámica de Scheker en el tratamiento de la artrosis trapeciometacarpiana
2017
Objetivo Evaluar los resultados clínicos y radiográficos de una serie de pacientes sometidos a una artroplastia de Scheker. Material y Método Estudio descriptivo de 16 pacientes con artrosis TMC. Se valoró el estado clínico y funcional según el cuestionario DASH, la movilidad del pulgar según la escala de Kapandji y el dolor según la escala visual analógica (EVA). A nivel radiográfico, se cuantificó el colapso del espacio remanente tras la exéresis del trapecio. Resultados La edad promedio de los pacientes fue 64,9 años, 81% fueron mujeres. El tiempo de seguimiento medio fue de 19 meses. La puntuación DASH preoperatoria fue de 67,68 puntos y postoperatoria 34,88 (p < 0.001). La puntuaci…