Search results for "IAP"

Age-related changes of NADPH-diaphorase-positive neurons in the rat inferior colliculus and auditory cortex

2007

Nitric oxide (NO) has been implied in age-related changes of the central nervous system (CNS) and the central auditory pathway. The present study was conducted to investigate whether the number of NO-producing cells and their morphometric characteristics in the inferior colliculus (IC) and the auditory cortex (AC) are changed with the increasing age of the subjects. IC and AC sections of adult and senile Wistar rats were studied using the histochemical detection of NADPH-diaphorase activity (NADPH-d), a marker for neurons containing nitric oxide synthase (NOS). Our results showed a decreased area of the somas of NADPH-d-positive neurons in the dorsal cortex (DC) of the IC and a diffuse loss…

Adjunctive clotiapine for the management of delusions in two adolescents with anorexia nervosa

2021

Clotiapine is an atypical antipsychotic indicated for the management of a series of acute psychotic disorders. The current literature lacks evidence concerning the tolerability and clinical use of this drug in the management of individuals with anorexia nervosa (AN). In this study, we report two cases of adolescents with AN, treated with clotiapine. The reason for the administration of clotiapine was, for both patients, the manifestation of bizarre delusions concerning food and calories. Patient 1 presented a presyncope after the first dose of clotiapine, and treatment was rapidly discontinued. Patient 2 was treated with clotiapine for 9 months; doses were titrated from 20 mg/day to 70 mg/d…

A Pedagogical Software for the Analysis of Loudspeaker Systems

2009

In this paper, a pedagogical software for the design and analysis of loudspeaker systems is presented, with emphasis on training students in the interaction between system parameters. Loudspeakers are complex electromechanical system, whose behavior is neither intuitive nor easy to understand by inexperienced students. Although commercial simulation software provides computation of the equations governing loudspeaker systems, they are mainly focused on the final product and are intended for experienced audio engineers. The proposed software was intentionally designed for education and training purposes. This software allows students to investigate loudspeaker systems that involve complex in…

Regulation of X Chromosome-Linked Inhibitor of Apoptosis Protein (XIAP) in Kainic Acid Induced Neuronal Cell Death in the Rat Hippocampus

2001

INTRODUCTION. Inhibitor of apoptosis protein (IAP) family consists of several antiapoptotic proteins conserved among species. The IAPs have a well-conserved motif of approximately 65 residues, called the baculovirus inhibitory repeat (BIR) (1). Baculovirus and drosophila IAPs have two, but most IAPs contain three BIR domains. Most of the IAPs also have a C-terminal RING domain which consists of conserved amino acids with zinc binding capacity. XIAP is one of the five known human IAPs and it binds directly and inhibits the activity of caspases (2). The BIR2 domain in XIAP is sufficient to mediate this inhibition (3). However little is known about the presence and function of XIAP in the nerv…

The case for strategic international alliances to harness nutritional genomics for public and personal health

2005

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need …

Laparoscopic treatment of diaphragmatic endometriosis causing chronic shoulder and arm pain

2009

Un inedito ritratto di Leonora Cybo nelle collezioni di Palazzo Falson a Malta

2013

Il saggio studia un affascinante ritratto della nobildonna toscana Leonora Cybo, oggi a Palazzo Falson Historic House Museum (Malta)

An enigmatic portrait of Leonora Cybo at Palazzo Falson

2013

An unpublished portrait of the Tuscan noblewoman Leonora Cybo is kept today at Palazzo Falson Historic House Museum in Mdina (Malta).

Expression and immunohistochemical localization of leptin in human periapical granulomas.

2014

Background Leptin, initially described as an adipocyte-derived hormone to regulate weight control, is expressed in normal and inflamed human dental pulp, being up-regulated during pulp experimental inflammation. Leptin receptor (LER) has been identified in human periapical granulomas. The aim of this study was to analyze and characterize the expression of leptin in human periapical granulomas. Material and Methods Fifteen periapical inflammatory lesions were obtained from extracted human teeth and teeth which underwent periapical surgery. After their morphological categorization as periapical granulomas and gradation of the inflammatory infiltrate, they were examined by immunohistochemistry…

Thoracic ultrasound: Potential new tool for physiotherapists in respiratory management. A narrative review

2016

International audience; The use of diagnostic ultrasound by physiotherapists is not a new concept; it is frequently performed in musculoskeletal physiotherapy. Physiotherapists currently lack accurate, reliable, sensitive, and valid measurements for the assessment of the indications and effectiveness of chest physiotherapy. Thoracic ultrasound may be a promising tool for the physiotherapist and could be routinely performed at patients' bedsides to provide real-time and accurate information on the status of pleura, lungs, and diaphragm; this would allow for assessment of lung aeration from interstitial syndrome to lung consolidation with much better accuracy than chest x-rays or auscultation…