Search results for "IBA"

Extrahepatic Morbidity and Mortality of Chronic Hepatitis C

2015

Chronic hepatitis C virus (HCV) infection is associated with several extra-hepatic manifestations. Patients with HCV may develop mixed cryoglobulinemia and its sequelae, ranging from cutaneous and visceral vasculitis to glomerulonephritis and B cell non-Hodgkin’s lymphoma. HCV-infected patients have increased rates of insulin resistance, diabetes and atherosclerosis, which may lead to increased cardiovascular morbidity and mortality. Neurologic manifestations of HCV infection include fatigue and cognitive impairment. The mechanisms causing the extra-hepatic effects of HCV infection are likely multifactorial and may include endocrine effects, HCV replication in extra-hepatic cells, or a heig…

Paenibacillus larvae Chitin-Degrading Protein PlCBP49 Is a Key Virulence Factor in American Foulbrood of Honey Bees

2014

Paenibacillus larvae, the etiological agent of the globally occurring epizootic American Foulbrood (AFB) of honey bees, causes intestinal infections in honey bee larvae which develop into systemic infections inevitably leading to larval death. Massive brood mortality might eventually lead to collapse of the entire colony. Molecular mechanisms of host-microbe interactions in this system and of differences in virulence between P. larvae genotypes are poorly understood. Recently, it was demonstrated that the degradation of the peritrophic matrix lining the midgut epithelium is a key step in pathogenesis of P. larvae infections. Here, we present the isolation and identification of PlCBP49, a mo…

La mordaza antiterrorista

2002

Mundus et: Idea. Homo. Communitas. Sciens : zinātnisko rakstu krājums

2021

LU Studentu zinātnisko rakstu krājums “Mundus et” ir Latvijas Universitātes Studentu padomes organizētās LU Studentu zinātniskās konferences “Mundus et” jauno pētnieku darbu apkopojums.

Le marketing tribal électronique: vers une rationalisation sociale généralisée de la socialisation en ligne ?

2010

International audience; L’instrumentalisation marchande du phénomène de socialisation électronique, sans nous questionner plus avant ici sur son efficacité économique réelle, réactualise la question de la rationalisation du lien social à l’heure de la massification d’Internet. Cette rationalisation est considérée par beaucoup de penseurs critiques, à la suite des travaux d’Habermas sur l’Espace Public, comme un affaiblissement, voire une disparition d’un être-ensemble détaché pour partie de la raison calculatoire, de la logique de l’intérêt. Ainsi, les stratégies marketing ciblant la population internaute, que l’on pourrait rassembler en nous inspirant de Bernard Cova et de Michel Maffesoli…

In silicoAntibacterial Activity Modeling Based on the TOMOCOMD-CARDD Approach

2015

In the recent times, the race to cope with the increasing multidrug resistance of pathogenic bacteria has lost much of its momentum and health professionals are grasping for solutions to deal with the unprecedented resistance levels. As a result, there is an urgent need for a concerted effort towards the development of new antimicrobial drugs to stay ahead in the fight against the ever adapting bacteria. In the present report, antibacterial classification functions (models) based on the topological molecular computational design-computer aided >rational> drug design (TOMOCOMD-CARDD) atom-based non-stochastic and stochastic bilinear indices are presented. These models were built using the li…

Una reflexión sobre la expulsión de los moriscos valencianos y la repoblación

2009

La historiografía sobre los moriscos y su expulsión ha estado determinada por todo un conjunto de prejuicios ideológicos. Los contemporáneos de la expulsión, al menos los que tuvieron ocasión de expresarse por escrito, adoptaron una posición que podemos llamar moriscófoba. Consideraban que la población morisca valenciana era económicamente poco relevante, dado el carácter minifundista y atrasado de la agricultura que practicaban. Al mismo tiempo pensaban que su población crecía a un ritmo mayor que la cristiana, debido al matrimonio universal y precoz que practicaban, ya que las que llamaban «cargas del matrimonio» eran para ellos poco exigentes y no practicaban el celibato. Los historiador…

Staphyloccocus epidermidis virulences faktoru un antibakteriālās rezistences noteikšana

2020

Darba aktualitāte: Neraugoties uz to, ka diagnosticēšanas un ārstniecības iespējas strauji attīstās, vēl joprojām aktuāla ir tēma par baktēriju rezistenci. S. epidermidis tiek uzskatīts par vienu no biežākajiem nazokomiālo infekciju ierosinātājiem. Šīs baktērijas svarīgākais virulences faktors ir biofilmas veidošanās. Ņemot vērā baktēriju īpašības, S. epidermidis izraisītās infekcijas kļūst grūti ārstējamas. Darba mērķis: Noteikt medicīnas studentu ādas mikroflorā (mikrobiota) esošos stafilokokus un identificēt S. epidermidis baktērijas, noteikt to virulences, antibakteriālo rezistenci un salīdzināt ar to stafilokoku celmu īpašībām, kas iegūti no klīniskā materiāla. Metodes un materiāli: Di…

Physiological pharmacokinetic model for ceftazidime disposition in the rat and its application to prediction of plasma concentrations in humans

1993

Abstract A physiological pharmacokinetic model for the disposition of ceftazidime in the rat was developed. The model is composed of 10 compartments which represent most of the organs and tissues of the body. Ceftazidime concentration-time profiles in the organs and tissues represented in the model were simulated and compared with the observed concentration-time data after i.v. administration of 5 and 20 mg of antibiotic. The model gave an acceptable description of the observed data. The steady-state volume of distribution and total clearance of ceftazidime in healthy humans predicted from data obtained in the rat (0.21 l/kg and 113 ml/min, respectively) were similar to the values reported …

Satisfacción de las mujeres con la duración del proceso de valoración adicional en el cribado mamográfico

2011

ResumenObjetivosConocer los factores asociados a la satisfacción con la duración del proceso de valoración adicional en el cribado mamográfico.MétodosEstudio transversal descriptivo y multivariado mediante encuesta telefónica a una muestra representativa de mujeres (N=316) participantes en el Programa de Prevención del Cáncer de Mama de la Comunidad Valenciana, que requirieron valoración adicional mediante pruebas complementarias para confirmar el diagnóstico. Análisis descriptivo mediante tablas de contingencia (p<0,05) y de asociación mediante odds ratio (OR) con modelos de regresión logística (intervalo de confianza del 95% [IC95%]).ResultadosLa satisfacción con la duración del proceso f…