Search results for "IBA"

Mononeuropathy multiplex as a result of treatment with interferon-α and ribavirin in a patient with hepatitis C

2008

Bisphosphonates affect migration ability and cell viability of HUVEC, fibroblasts and osteoblasts in vitro

2010

Oral Diseases (2011) 17, 194–199 Objectives:  Bisphosphonate-associated osteonecrosis of the jaw (BP-ONJ) is a side effect in patients being treated with bisphosphonates. The bisphosphonates most often associated with BP-ONJ are the highly potent nitrogen-containing bisphosphonates, e.g. pamidronate or zoledronate. In terms of BP-ONJ aetiology, several theories are being discussed: inhibition of bone remodelling, effect on soft tissues, and antiangiogenic effect of bisphosphonates. The aim of this in vitro study was to investigate the effect of different potent bisphosphonates on osteoblasts, fibroblasts and human umbilicord vein endothelial cells (HUVEC). Materials and methods:  Three nitr…

High pressure processing of food-grade emulsion systems: Antimicrobial activity, and effect on the physicochemical properties

2019

Abstract The use of high pressure processing (HPP) for development of stable emulsion-based delivery systems has been recently increased. Under adequate conditions, application of high pressures modifies the functionality of protein and polysaccharide molecules and significantly promotes the emulsifying activities. Application of high pressures also modulates the emulsion microstructure without any destabilization and gelation of protein molecules. The lipid oxidation in HPP-treated emulsions can be accelerated, particularly with higher pressure levels, while the HPP utilization on emulsions in acidic conditions can highly inhibit the growth of spoilage and pathogenic microorganisms. In thi…

New phenolics, cytotoxicity and chemosystematic significance of Atriplex semibaccata

2019

Abstract The chemical characterization of the 70% hydromethanolic extract of Atriplex semibaccata (family: Chenopodiaceae) afforded a new methoxylated flavonol triglycoside, atrisemibaccatoside A (1), and a new lignanamide, (N-[(E)-m-hydroxycinnamoyl]tyramine (7), as well as, five known flavonols (2–6) and two lignanamides (8–9). The structures of the isolated compounds were established depending upon LR&HR-FAB-MS, 1D and 2D NMR spectroscopic analyses. The cytotoxic activity of the isolated compounds (1–4, and 7–9) was investigated. Compounds 7, 8 and 9 weakly inhibited the proliferation of leukemia CCRF-CEM cells with IC50 values of 78.5, 46.3, and 71.2 μg/ml, respectively, and exhibited n…

Factors influencing axillary shoot proliferation and adventitious budding in cedar.

2005

We developed procedures for in vitro cloning of Cedrus atlantica Manetti and C. libani A. Rich explants from juvenile and mature plants. Explant size was one determinant of the frequency of axillary bud break in both species. Shoot tips and nodal explants mainly developed calli, whereas bud sprouting occurred in defoliated microcuttings cultured on a modified Murashige and Skoog medium without growth regulators. Isolation and continuous subculture of sprouted buds on the same medium allowed cloning of microcuttings from C. atlantica and C. libani seedlings and bicentennial C. libani trees, thus providing a desirable alternative for multiplying mature trees that have demonstrated superior ch…

Molecular/chemical ecology in sponges. Evidence for an adaptive antibacterial response in Suberites domuncola

2004

Sponges (Porifera) represent the evolutionary oldest metazoan phylum still extant today. They have developed a complex Bauplan, based on the existence of structural and regulatory molecules; many of these have been cloned and analyzed in the past years. The demosponge Suberites domuncula has been used as a suitable model to demonstrate that these animals not only possess an adaptive immune response on the level of cytokines, but also, as pointed out here, on the level of synthesis of bioactive alkyl-lipid derivatives. From specimens of S. domuncula the two lyso-PAF (platelet-activating factor) compounds, 1-O-hexadecyl-sn-glycero-3-phosphocholine and 1-O-octadecyl-sn-glycero-3-phosphocholine…

UJI AKTIVITAS ANTIBAKTERI DAN SKRINING FITOKIMIA EKSTRAK HEKSANA, ETIL ASETAT DAN METANOL TUMBUHAN SURUHAN (Peperomia pellucida L. Kunth)

2020

Antibacterial activity test and screening of phytochemical of extract hexane, ethyl acetate  and methanol have been carried out. The extraction of the P.pellucida plants was carried out by the maceration method in stages based on the polarity of the solvent. Analysis of chemical compounds done with phytochemical screening test. Based on the identification of chemical compounds by phytochemical screening, hexane and ethyl acetate extract has been detected only in the presence of flavonoid compounds with moderate categories. Methanol  extract contains high-grade alkaloids and moderate flavonoid and tannin compounds. Antibacterial test using disffusion methods suggest that ethyl acetate and me…

Molecular topology: a useful tool for the search of new antibacterials.

2000

Molecular topology has been applied to find new lead antibacterial compounds. Among the selected compounds, hesperidin, neohesperidin and Mordant Brown 24 stand out, with minimum inhibitory concentrations 90, MIC90<0.3 mg / mL.

Saponin with antibacterial activity from the roots of Albizia adianthifolia

2019

AbstractAn unprecedented saponin is being reported herein together with five known compounds from the methanol extract of the roots of Albizia adianthifolia. The metabolites were obtained over repe...

Oxidative halogenation of substituted pyrroles with Cu(II). PartIV.Bromination of 2-(2′-hydroxybenzoyl)pyrrole. A new synthesis of bioactive analogs …

1994

The selective bromination with copper(II) bromide of the pyrrole ring in 2-(2'-hydroxybenzoyl)pyrrole (II) in the heterogeneous phase is des- cribed giving in almost quantitative yield the 4,5-dibromo derivative (VI). The subsequent introduction of halogen into the phenol moiety was observed when the reaction was perfomed in the homogeneous phase with an excess of halogenating agent. The pentabromo derivative (IX), a com- pound very active against Staphylococcus aureus (mic=17 nmoles per dm -3 ), was obtained by exhaustive bromination of the title compound. Poor yields of chloro derivatives of (II) were obtained by reaction of the parent compound with copper(II) chloride