Search results for "IBA"

X-ray Crystal Structure of Woodinine and Conformational Analysis by Semiempirical and 1H-NMR Methods

1997

The mol. structure of (-)-woodinine (I), a carboline-based alkaloid with antibacterial and antimycobacterial activities, was investigated by X-ray crystallog., NMR, and semiempirical quantum chem. methods. The X-ray crystal structure of I showed the indole ring in the expected planar conformation, the pyrrolidine ring in an envelope conformation, and a weak intramol. hydrogen bond between the pyrrolidine nitrogen and the proton of the indole nitrogen. NMR expts. indicated that this hydrogen bond is not present in soln. and that further differences exist between the crystal and the soln. structures of I. By semiempirical quantum chem. methods, different local energy min. conformations of I, …

Erythromycin exertsin vivoanti-inflammatory activity downregulating cell adhesion molecule expression

2005

1. Macrolides have long been used as anti-bacterial agents; however, there is some evidence that may exert anti-inflammatory activity. Therefore, erythromycin was used to characterize the mechanisms involved in their in vivo anti-inflammatory activity. 2. Erythromycin pretreatment (30 mg kg(-1) day(-1) for 1 week) reduced the lipopolysaccharide (LPS; intratracheal, 0.4 mg kg(-1))-induced increase in neutrophil count and elastase activity in the bronchoalveolar lavage fluid (BALF) and lung tissue myeloperoxidase activity, but failed to decrease tumor necrosis factor-alpha and macrophage-inflammatory protein-2 augmented levels in BALF. Erythromycin pretreatment also prevented lung P-selectin,…

Interferon-?? Alone versus Interferon-?? plus Ribavirin in Patients with Chronic Hepatitis C Not Responding to Previous Interferon-?? Treatment

2000

Objective: To study the effects of monotherapy with leucocyte interferon-α (IFNα) versus IFNα + ribavirin in patients with chronic hepatitis C who were nonresponders to previous courses of recombinant or lymphoblastoid IFNα. Design and setting: This was a nonblind randomised study of outpatients at 3 centres in Palermo, Sicily, Italy. Patients and participants: We recruited 72 patients (48 males, 24 females), mean age 48.8 ± 6.6 years (range 31 to 63 years), with biopsy-proven chronic hepatitis C, predominantly genotype lb. Interventions: 24 patients (group A) received IFNα 6MU 3 times weekly for 6 months, and 48 patients (group B) received IFNα 6MU 3 times weekly + ribavirin 1200 mg/day fo…

Epidemiology of Mycobacterial Resistance(Especially <i>Mycobacterium tuberculosis</i>)

1999

Treatment of patients with duodenal ulcer positive for helicobacter pylori infection: ranitidine or omeprazole associated with colloidal bismuth subc…

1996

Abstract This study evaluated treatment of patients affected with duodenal ulcer positive for Helicobacter pylori . We compared patients treated with ranitidine plus amoxicillin plus colloidal bismuth subcitrate (n = 20) with patients treated with omeprazole plus amoxicillin plus colloidal bismuth subcitrate (n = 20) with regard to: (1) healing of duodenal ulcer; (2) eradication of H pylori ; and (3) recurrence of ulcer. Baseline and follow-up for 24 months were performed through clinical, laboratory, and endoscopic tests. The ulcer healing rate was 95% in the ranitidine group and 100% in the omeprazole group; the H pylori eradication rate was 90% and 95%, respectively. During follow-up, on…

Identificación de oportunidades de mejora del tratamiento de la hepatitis C

2006

® . Summary Objective: Hepatitis C represents a public health concern with more than 170 million carriers. The goal of this study was to identify improvement opportunities in the management of hepati- tis C, and the pharmaceutical actions performed for the preven- tion and solution of medication-related problems in patients seen at the Pharmaceutical Care Outpatient Unit.

Properties of dirty two-band superconductors with repulsive interband interaction: Normal modes, length scales, vortices, and magnetic response

2018

Disorder in two-band superconductors with repulsive interband interaction induces a frustrated competition between the phase-locking preferences of the various potential and kinetic terms. This frustrated interaction can result in the formation of an $s+is$ superconducting state, that breaks the time-reversal symmetry. In this paper we study the normal modes and their associated coherence lengths in such materials. We especially focus on the consequences of the soft modes stemming from the frustration and time-reversal-symmetry breakdown. We find that two-bands superconductors with such impurity-induced frustrated interactions display a rich spectrum of physical properties that are absent i…

Enhanced chemiluminescent determination of chloramphenicol and related nitro compounds by ‘on-line’ photochemical reaction

2000

The viability of tandem photochemical reaction-chemiluminescence detection was studied for a heterogeneous family of nitro compounds using chloramphenicol as a test substance. The 'on-line' chemical photodegradation of chloramphenicol was performed in a flow injection assembly by using a photoreactor consisting of a 725 cm x 0.5 mm id piece of PTFE tubing coiled around an 8 W low-pressure mercury lamp. Photodegraded chloramphenicol was detected by oxidizing photo-fragments from the parent compound and their subsequent reaction with a luminol-Co(II) system. The calibration graph was linear up to 3 x 10(-5) mol l-1 chloramphenicol, the limit of detection was 3 x 10(-9) mol l-1, the relative s…

Pirmsskolas vecuma bērnu patstāvības pilnveide pedagoģiskajā procesā

2018

Darba nosaukums: Pirmsskolas vecuma bērnu patstāvības pilnveide pedagoģiskajā procesā. Darba autors: Kristīne Hartmane Darba mērķis: Teorētiski un praktiski izzināt pirmsskolas vecuma bērnu patstāvības pilnveides iespējas pedagoģiskajā procesā. Pirmajā nodaļā autore ir pētījusi pedagoģijas un psiholoģijas zinātnieku atziņas par patstāvību, raksturojusi pirmsskolas vecuma bērnus patstāvības kontekstā, kā arī aplūkojusi patstāvības pilnveides iespējas pedagoģiskajā procesā. Otrajā nodaļā tiek atspoguļots praktiskais pētījums bērnu patstāvības pilnveidei pedagoģiskajā procesā. Ņemot vērā pētījumā iegūtos rezultātus, autore secina, ka izvirzītais pētījuma jautājums ir apstiprinājies, proti, pir…

Vecākā pirmsskolas vecuma bērnu gribas īpašību sekmēšana mājturības un tehnoloģijas rotaļnodarbībās

2017

Budzilko E. “Vecākā pirmsskolas vecuma bērnu gribas īpašību sekmēšana mājturības un tehnoloģijas rotaļnodarbībās” kvalifikācijas darbs. Rīga: LU pedagoģijas, psiholoģijas un mākslas fakultāte, 2017, 41 lpp. Kvalifikācijas darbs satur 8 tabulas, 10 attēlus, 33 izmantotās literatūras avotus un 2 pielikumus. Darba mērķis tika sasniegts veicot teorētiskās literatūras analīzi un praktisko pētījumu, izmantojot anketēšanas, sarunas ar bērniem (intervijas), novērošanas metodes. Kvalifikācijas darba teorētiskās literatūras analīze liecina, ka personības veselumu veido trīs līdzsvarotu komponentu kopums – prāts, jūtas, griba. Ļoti svarīga ir skolotāja personība un zināšanas par bērnu attīstības likum…