Search results for "IDP"
showing 10 items of 36 documents
Nouvelles perspectives concernant la structure et la fonction du domaine carboxyl terminal de Hfq
2015
Accumulating evidence indicates that RNA metabolism components assemble into supramolecular cellular structures to mediate functional compartmentalization within the cytoplasmic membrane of the bacterial cell. This cellular compartmentalization could play important roles in the processes of RNA degradation and maturation. These components include Hfq, the RNA chaperone protein, which is involved in the post-transcriptional control of protein synthesis mainly by the virtue of its interactions with several small regulatory ncRNAs (sRNA). The Escherichia coli Hfq is structurally organized into two domains. An N-terminal domain that folds as strongly bent β-sheets within individual protomers to…
Bibliotēkas izveide pakalpojuma sniedzēja pierakstīšanās funkcionalitātes ar identitātes sniedzēja imitāciju testēšanai
2021
Kvalifikācijas darbā “Bibliotēkas izveide pakalpojuma sniedzēja pierakstīšanās funkcionalitātes ar identitātes sniedzēja imitāciju testēšanai” šī darba autors ir izveidojis testēšanas bibliotēku, ar kuras palīdzību lietotājs var uzģenerēt korektu SAML 2.0 apgalvojumu un atbildi, ko lietotājs var nosūtīt savam izvēlētajam pakalpojuma sniedzējam, lai pierakstītos pakalpojuma sniedzēja produktā. Šī bibliotēka atvieglo automatizēto lietotājsaskarņu testēšanas procesu sekojošos veidos: - Samazina lietotājsaskarņu testa soļu daudzumu (Selenium komandas), kas uzlabo testu stabilitāti; - Noņem testu atkarību no trešo pušu pakalpojumu sniedzējiem; - Atļauj dinamiski mainīt sistēmas lietotāju atribūt…
Dispersion from C
2019
Resonance assignment of intrinsically disordered proteins is remarkably challenging due to scant chemical shift dispersion arising from conformational heterogeneity. The challenge is even greater if repeating segments are present in the amino acid sequence. To forward unambiguous resonance assignment of intrinsically disordered proteins, we present iHACANCO, HACACON and (HACA)CONCAHA, three Hα-detected 4D experiments with Cα as an additional dimension. In addition, we present (HACA)CON(CA)NH and (HACA)N(CA)CONH, new 4D Hα-start, HN-detect experiments which have two NH dimensions to enhance peak dispersion in a sequential walk through C′, NH and HN, and provide more accurate NH/HN chemical s…
A novel pyruvate kinase (PK-S) from boar spermatozoa is localized at the fibrous sheath and the acrosome
2007
Boar spermatozoa contain a novel pyruvate kinase (PK-S) that is tightly bound at the acrosome of the sperm head and at the fibrous sheath in the principal piece of the flagellum, while the midpiece contains a soluble pyruvate kinase (PK). PK-S could not be solubilized by detergents, but by trypsin with no loss of activity. Purified PK-S as well as PK-S still bound to cell structures and soluble sperm PK have all kinetics similar to those of rabbit muscle PK-M1. The PK-S subunit had a relative molecular mass of 64 ± 1 × 103(n= 3), i.e. slightly higher than that of PK-M1, and carried an N-terminal extension (NH2-TSEAM-COOH) that is lacking in native PK-M1. Evidence is provided that PK-S is en…
Novel Digital Measurement Technique to Analyze the Palatine Suture Expansion after Palatine Rapid Maxillary Expansion Technique
2021
The aim of the study was to validate a novel digital measurement method to quantify the volume of the midpalatal suture after rapid maxillary expansion (RME). Material and methods: Eight patients with maxillary skeletal transverse deficiency were submitted to palatine suture expansion using the McNamara orthodontic appliance during a period of nine months. After 30 days of treatment, all patients were exposed postoperatively to a cone-beam computed tomography (CBCT) scan. Afterwards, the scans were uploaded into the three-dimensional orthodontic-planning software to allow the volumetric assessment of the palatine suture expansion through palatine rapid maxillary expansion using a McNamara a…
Monotonic solution of heterogeneous anisotropic diffusion problems
2013
Anisotropic problems arise in various areas of science and engineering, for example groundwater transport and petroleum reservoir simulations. The pure diffusive anisotropic time-dependent transport problem is solved on a finite number of nodes, that are selected inside and on the boundary of the given domain, along with possible internal boundaries connecting some of the nodes. An unstructured triangular mesh, that attains the Generalized Anisotropic Delaunay condition for all the triangle sides, is automatically generated by properly connecting all the nodes, starting from an arbitrary initial one. The control volume of each node is the closed polygon given by the union of the midpoint of…
RESUMEN EJECUTIVO DEL CONSENSO DE EXPERTOS SOBRE LA EFICACIA Y SEGURIDAD DE LOS iDPP-4 EN EL TRATAMIENTO DE PACIENTES CON DIABETES Y COVID-19
2021
Resumen Antecedentes El objetivo de este consenso es esclarecer el papel de los iDPP-4 en el manejo de los pacientes con diabetes durante la pandemia por COVID-19. Material y metodos Se llevo a cabo una busqueda bibliografica en PubMed (diciembre 2019-febrero de 2021). Se empleo la metodologia Oxford y se establecieron de forma consensuada posibles recomendaciones. Resultados La diabetes parece ser un factor independiente en la enfermedad de COVID-19 (evidencia 2b). No se demuestra mayor riesgo de contagio con iDPP-4 (evidencia 2b), y su uso ha demostrado ser seguro (evidencia 2b). Los iDPP-4 pueden presentar un cierto beneficio en la reduccion de la mortalidad, particularmente su uso intra…
Página web GIDPTD (Grupo de Innovación Docente Patología y Terapéutica Dental)
2012
Se trata de una página web del grupo de innovación docente en patología dental, odontología conservadora y endodoncia encaminada a facilitar al estudiante material complementario, sobre todo iconografía y situaciones clínicas que puedan complementar su formación.
Hyaluronic acid dressing of Hydrophobic Carbon Nanodots: a Self-assembling Strategy of Hybrid Nanocomposites with Theranostic Potential
2021
We propose a rational design of hyaluronic acid-dressed red-emissive carbon dots (CDs), with a well-structured hydrophobic core capable of locally delivering high amount doxorubicin (Doxo) (> 9% w/w) and heat (hyperthermia) in a light stimuli sensitive fashion. We combined in a unique micelle-like superstructure the peculiar optical properties of CDs (NIR photothermal conversion and red fluorescence) with the ability of hyaluronic acid (HA) shell of stabilizing nanomedicines in aqueous environment and recognizing cancer cells overexpressing CD44 receptors on their membranes, thus giving rise to smart theranostic agents useful in cancer imaging and NIR-triggered chemo-phototherapy of solid t…
Small-sample characterization of stochastic approximation staircases in forced-choice adaptive threshold estimation
2007
Despite the widespread use of up—down staircases in adaptive threshold estimation, their efficiency and usability in forced-choice experiments has been recently debated. In this study, simulation techniques were used to determine the small-sample convergence properties of stochastic approximation (SA) staircases as a function of several experimental parameters. We found that satisfying some general requirements (use of the accelerated SA algorithm, clear suprathreshold initial stimulus intensity, large initial step size) the convergence was accurate independently of the spread of the underlying psychometric function. SA staircases were also reliable for targeting percent-correct levels far …