Search results for "IDS"

Bērnu fiziskās attīstības veicināšana vidējā pirmsskolas vecuma bērniem

2021

Darba autors – Žaklīna Pahmurkina Bakalaura darba tēma – “Bērnu fiziskās attīstības veicināšana vidējā pirmsskolas vecuma bērniem”. Pētījuma mērķis – analizēt bērnu fiziskās attīstības veicināšanas pedagoģiskās iespējas vidējā pirmsskolas vecumā. Bakalaura darbs sastāv no divām daļām – teorētiskās un empīriskās daļas. Teorētiskajā daļā ir analizētas pedagoģijas, psiholoģijas zinātnieku un filosofu atziņas par veselīga dzīvesveida izpratni un raksturojumu, kas sadalītas trīs apakšnodaļās. Pirmajā apakšnodaļā ir analizētas atziņas par vidējā pirmsskolas vecumposma bērnu vispārīgo attīstību, apskatīti veselīga dzīvesveida būtība un nosacījumi pirmsskolas pedagoģiskajā procesā un izceltas atziņ…

High-Reynolds-number turbulent cavity flow using the lattice Boltzmann method

2018

We present a boundary condition scheme for the lattice Boltzmann method that has significantly improved stability for modeling turbulent flows while maintaining excellent parallel scalability. Simulations of a three-dimensional lid-driven cavity flow are found to be stable up to the unprecedented Reynolds number $\mathrm{Re}=5\ifmmode\times\else\texttimes\fi{}{10}^{4}$ for this setup. Excellent agreement with energy balance equations, computational and experimental results are shown. We quantify rises in the production of turbulence and turbulent drag, and determine peak locations of turbulent production.

Designing a graphics processing unit accelerated petaflop capable lattice Boltzmann solver: Read aligned data layouts and asynchronous communication

2016

The lattice Boltzmann method is a well-established numerical approach for complex fluid flow simulations. Recently, general-purpose graphics processing units (GPUs) have become available as high-performance computing resources at large scale. We report on designing and implementing a lattice Boltzmann solver for multi-GPU systems that achieves 1.79 PFLOPS performance on 16,384 GPUs. To achieve this performance, we introduce a GPU compatible version of the so-called bundle data layout and eliminate the halo sites in order to improve data access alignment. Furthermore, we make use of the possibility to overlap data transfer between the host central processing unit and the device GPU with com…

Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane

2021

Herpes simplex virus capsids are assembled and packaged in the nucleus and move by diffusion through the nucleoplasm to the nuclear envelope for egress. Analyzing their motion provides conclusions not only on capsid transport but also on the properties of the nuclear environment during infection. We utilized live-cell imaging and single-particle tracking to characterize capsid motion relative to the host chromatin. The data indicate that as the chromatin was marginalized toward the nuclear envelope it presented a restrictive barrier to the capsids. However, later in infection this barrier became more permissive and the probability of capsids to enter the chromatin increased. Thus, although …

The closest relatives of icosahedral viruses of thermophilic bacteria are among viruses and plasmids of the halophilic archaea.

2009

We have sequenced the genome and identified the structural proteins and lipids of the novel membranecontaining, icosahedral virus P23-77 of Thermus thermophilus. P23-77 has an 17-kb circular double-stranded DNA genome, which was annotated to contain 37 putative genes. Virions were subjected to dissociation analysis, and five protein species were shown to associate with the internal viral membrane, while three were constituents of the protein capsid. Analysis of the bacteriophage genome revealed it to be evolutionarily related to another Thermus phage (IN93), archaeal Halobacterium plasmid (pHH205), a genetic element integrated into Haloarcula genome (designated here as IHP for integrated Ha…

Lipid Binding Controls Dimerization of the Coat Protein p24 Transmembrane Helix

2019

Abstract Coat protein (COP) I and COP II complexes are involved in the transport of proteins between the endoplasmic reticulum and the Golgi apparatus in eukaryotic cells. The formation of COP I/II complexes at membrane surfaces is an early step in vesicle formation and is mastered by p24, a type I transmembrane protein. Oligomerization of p24 monomers was suggested to be mediated and/or stabilized via interactions within the transmembrane domain, and the p24 transmembrane helix appears to selectively bind a single sphingomyelin C18:0 molecule. Furthermore, a potential cholesterol-binding sequence has also been predicted in the p24 transmembrane domain. Thus, sphingomyelin and/or cholestero…

Single amino acid substitutions in the glycoprotein B carboxy terminus influence the fusion from without property of herpes simplex virus type 1.

1995

Syncytial mutations of herpes simplex virus type 1 (HSV-1) strains ANG, ANG path, HFEM, tsB5 and HSZP cause extensive cell fusion and were mapped to the cytoplasmic domain of glycoprotein B (gB), within the syn 3 locus. These strains are so far the only ones which show the phenotype ‘fusion from without’ (FFWO): 60 min after infection with high m.o.i., cells in a tissue culture are fused without transcription and translation of the viral genome. In this report we detected, using the recombinants 27/III and K-7, that an amino acid exchange from Ala to Val at aa position 854 of gB is the main determinant for FFWO activity of strains ANG, ANG path and recombinant K-7. The transfer of this muta…

Kolāžu izmantošana vārdu krājuma nostiprināšanai angļu valodas stundās 3. klasē

2015

Diplomdarba mērķis bija atrast veidu, kā nostiprināt vārdu krājumu svešvalodā 3. klasē, pārvēršot to par aktīvu vārdu krājumu, izmantojot kolāžas. Darba tēma tika izvēlēta, jo autore tic, ka vārdu krājums ir pamats svešvalodu apgūšanā. Skolotāja uzdevums ir palīdzēt skolēniem apgūt vārdu krājumu, izmantojot vizuālos materiālus mācību procesā pēc iespējas vairāk. Izvēlētā pētījuma metode bija atsevišķa gadījuma pētījums, kas tika veikts Rīgas 32. vidusskolā 3. klasē. Datu vākšanas metodes bija 2 testi skolēniem, intervija ar vietējo angļu valodas skolotāju un skolēnu anketa. Pētījums pierādīja to, ka skolēni izbaudīja laiku veidojot kolāžas, turklāt skolēni nostiprināja vārdu krājumu angļu v…

HS-SPME and GC-MS as valid tools to assess volatile organic compounds from soil natural organic matter

2008

Prescription opioid use and employment : A nationwide Finnish register study

2021

Background: The secular decline in labor market participation and the concurrent increase in opioid use in many developed countries have sparked a policy debate on the possible connection between these two trends. We examined whether the use of prescription opioids was connected to labor market outcomes relating to participation, employment and unemployment among the Finnish population. Methods: The working-age population (aged 19–64 years) living in Finland during the period 1995–2016 was used in the analyses (consisting of 67 903 701 person-year observations). Lagged values of prescription opioid use per capita were used as the exposure. Instrumental variables (IV) estimation method was u…