Search results for "IIN"
showing 10 items of 1385 documents
Examining the relationship between public speaking anxiety, distress tolerance and psychological flexibility
2020
Public speaking is an important skill for university students to learn and practice as they progress through education and into their careers. However, individuals often avoid facing public speaking, as they lack the skills to cope with the anxiety that arises when speaking in front of others. The current study aimed to investigate the relationship between public speaking anxiety, distress tolerance, and psychological flexibility. A sample of 95 college students completed psychological flexibility measures and self-ratings of public speaking anxiety before and after a public speaking challenge. A behavioral index of public speaking distress tolerance (i.e., speech duration) was also recorde…
Structural Studies Reveal that Endosomal Cations Promote Formation of Infectious Coxsackievirus A9 A-Particles, Facilitating RNA and VP4 Release
2022
Coxsackievirus A9 (CVA9), an enterovirus, is a common cause of pediatric aseptic meningitis and neonatal sepsis. During cell entry, enterovirus capsids undergo conformational changes leading to expansion, formation of large pores, externalization of VP1 N termini, and loss of the lipid factor from VP1. Factors such as receptor binding, heat, and acidic pH can trigger capsid expansion in some enteroviruses. Here, we show that fatty acid-free bovine serum albumin or neutral endosomal ionic conditions can independently prime CVA9 for expansion and genome release. Our results showed that CVA9 treatment with albumin or endosomal ions generated a heterogeneous population of virions, which could b…
Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease
2023
Numerous studies have described specific metabolites as biomarkers ofsevere liver diseases, but very few have measured gut microbiota (GM)-produced metab-olites in fatty liver disease. We aimed atfinding GM signatures and metabolite markersin plasma and feces related to high liver fat content. Based on imaging, we dividedstudy participants into low (,5%, LF,n= 25) and high (.5%, HF,n= 39) liver fatgroups. Fecal (LFn= 14, HFn= 25) and plasma (LFn= 11, HFn= 7) metabolomes ofsubsets of participants were studied using liquid chromatography/high resolution massspectrometry. The GM were analyzed using 16S rRNA gene sequencing. Additionally,blood clinical variables and diet were studied. Dyslipide…
Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins
2022
Autonomous parvoviruses encode at least two nonstructural proteins, NS1 and NS2. While NS1 is linked to important nuclear processes required for viral replication, much less is known about the role of NS2. Specifically, the function of canine parvovirus (CPV) NS2 has remained undefined. Here we have used proximity-dependent biotin identification (BioID) to screen for nuclear proteins that associate with CPV NS2. Many of these associations were seen both in noninfected and infected cells, however, the major type of interacting proteins shifted from nuclear envelope proteins to chromatin-associated proteins in infected cells. BioID interactions revealed a potential role for NS2 in DNA remodel…
The king who came down from the mountain : the image and the cult of personality of the "eternal president" Kim Il-Sung in official state propaganda …
2017
Tutkielma käsittelee Korean Demokraattisen Kansantasavallan (KDKT) ensimmäisen päämiehen ja johtajan Kim il-Sungin henkilökultin luomistyötä, sekä esikuvia, joita hän propagandakoneistonsa kanssa käytti henkilökulttinsa luomiseen. Tarkasteltu ajanjakso sijoittuu vuodesta 1945 noin vuoden 1962 loppuun. Alun perin Neuvostoliiton asevoimien tuella valtaan noussut nuori johtaja ryhtyi pian kehittämään itselleen omanlaistaan henkilökulttia, jonka esikuvina toimivat niin Neuvostoliiton Josef Stalin kuin myös kansallissosialistisen Saksan Adolf Hitler. Molemmat edellä mainitut diktaattorit toimivat Kim il-Sungille esimerkkinä monilla kulttuurin ja propagandan saroilla, niin esimerkiksi maalaustait…
CCDC 1581480: Experimental Crystal Structure Determination
2018
Related Article: Hendrik V. Schröder, Felix Witte, Marius Gaedke, Sebastian Sobottka, Lisa Suntrup, Henrik Hupatz, Arto Valkonen, Beate Paulus, Kari Rissanen, Biprajit Sarkar, Christoph A. Schalley|2018|Org.Biomol.Chem.|16|2741|doi:10.1039/C8OB00415C
Isovector and isoscalar spin-multipole giant resonances in the parent and daughter nuclei of double-β-decay triplets
2022
The strength distributions, including giant resonances, of isovector and isoscalar spin-multipole transitions in the commonly studied double-β-decay triplets are computed in the framework of the quasiparticle random-phase approximation (QRPA) using the Bonn-A two-body interaction in no-core single-particle valence spaces. The studied nuclei include the double-β parent and daughter pairs (76Ge, 76Se), (82Se, 82Kr), (96Zr, 96Mo), (100Mo, 100Ru), (116Cd, 116Sn), (128Te, 128Xe), (130Te, 130Xe), and (136Xe, 136Ba). The studied transitions proceed from the ground states to the Jπ=0−,1−,2− (spin-dipole transitions) and Jπ=1+,2+,3+ (spin-quadrupole transitions) excited states in these nuclei. Compa…
The impact of direct acting antivirals on hepatitis C virus disease burden and associated costs in four European countries
2021
Eliminació del VHC; Punt d'equilibri; Infecció d'hepatitis C Eliminación del VHC; Punto de equilibrio; Infección de hepatitis C HCV elimination; Break-even; Hepatitis C infection Background and Aims We assessed the clinical and economic impact of direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) in England, Italy, Romania and Spain. Methods An HCV progression Markov model was developed considering DAA eligibility and population data during the years 2015-2019. The period of time to recover the investment in DAAs was calculated as the cost saved by avoiding estimated clinical events for 1000 standardized treated patients. A delayed treatment scenario because of coronavirus di…
Self-reported antibiotic stewardship and infection control measures from 57 intensive care units: An international ID-IRI survey
2022
Infection control; Multidrug resistance; Stewardship Control de infección; Resistencia a múltiples fármacos; Administración Control d'infecció; Resistència a múltiples fàrmacs; Administració We explored the self-reported antibiotic stewardship (AS), and infection prevention and control (IPC) activities in intensive care units (ICUs) of different income settings. A cross-sectional study was conducted using an online questionnaire to collect data about IPC and AS measures in participating ICUs. The study participants were Infectious Diseases–International Research Initiative (IDI-IR) members, committed as per their institutional agreement form. We analyzed responses from 57 ICUs in 24 countri…
El estrés social produce ansiedad e incrementa los efectos reforzantes de la cocaína: utilidad de los antiinflamatorios
2018
poster presentado al congreso de patología dual en madrid en abril de 2018