Search results for "IL-4"

Izvēlētu benzoskābes atvasinājumu asociācijas pētījumi, izmantojot IS un KMR spektroskopiju

2020

Darba literatūras daļā apskatīts kodolmagnētiskās rezonanses spektroskopijas un infrasarkanās spektroskopijas būtība, tās pielietojums un citu pašasociācijas pētījumu rezultāti, izmantojot KMR un IS spektroskopiju. Eksperimentāli uzņemti infrasarkanie spektri 2-metil-4-nitrobenzoskābei, 2,6-dimetoksibenzoskābes un 3-hidroksibenzoskābes šķīdumiem dažādos šķīdinātājos, 1H un 13C KMR spektri 2,6-dimetoksibenzoskābes un 3-hidroksibenzoskābes šķīdumiem dažādos šķīdinātājos, veikti teorētiskie asociācijas pētījumi izmantojot Gaussian 09W un molekulārās dinamikas simulācija izmantojot Gromacs. IS spektri apstrādāti, veicot signālu pielāgošanu, KMR spektri apstrādāti izmantojot programmu MestReNova…

Jaunu alkilaizvietotu 4-fenil-2-pirolidonu sintēze un ķīmisko īpašību izpēte

2016

Jaunu alkilaizvietotu 4-fenil-2-pirolidonu sintēze un ķīmisko īpašību izpēte. Baškevičs V., darba vadītāji: Dr.chem. Maksims Vorona, asoc. prof. Anda Prikšāne. Bakalaura darbs. 32 lappuses, 18 attēli, 18 literatūras avoti. Latviešu valodā. Izstrādātas jaunas 5-alkilaizvietoto 4-fenil-2-pirolidonus iegūšanas metodes, izmantojot malonātu vai 2-fluormalonāta esteru Mihaela pievienošanu -alkil--nitrostirolam, kā arī nitroalkānu pievienošanu kanēļskābes metilesterim. Iegūtie starpprodukti tika hidrogenēti paaugstinātā spiedienā Reneja niķeļa katalizatora klātbūtnē, veidojot 5-alkil-4-fenil-3-karboksi-2-pirolidonu un 5-metil-4-fenil-3-fluoro-3-karboksi-2-pirolidona esterus, vai 5-alkil-4-fenil-…

A risk-adapted approach to treating respiratory syncytial virus and human parainfluenza virus in allogeneic stem cell transplantation recipients with…

2017

Here we report the applicability of a protocol based on clinical conditions and risk factors (RFs) for managing 35 allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients who developed a total of 52 episodes of respiratory viral infections (RVIs) caused by respiratory syncytial virus (RSV; n=19), human parainfluenza virus (HPIV; n=29), or both (n=4) over a 2-year study period. Risk categories were classified as high risk (cat-1) when the immunodeficiency scoring index was >= 3 and/or >= 3 RFs and/or >= 1 co-infective virus(es) were present; the remaining cases were classified as low risk (cat-0). The presence of two or more signs or symptoms including fever (T>38 degrees C…

Possible involvement of the IL4 gene in Waldenström's macroglobulinemia

1994

Abstract We report the results of a molecular investigation of 11 patients affected by Waldenstrom's macroglobulinemia, a rare B-cell malignancy characterized by an excessive proliferation of immunoglobulin(Ig)M-secreting plasmacytoid cells. In particular, we studied the interleukin-4 (IL4) gene, which codes for a B-specific growth factor capable of stimulating the proliferation and differentiation of secreting plasma cells. By Southern hybridization, in three patients we found the presence of additional bands in comparison with the expected pattern; moreover, these bands showed a different degree of intensity.

Therapeutic implications of Cancer Initiating Cells.

2009

Background: Until few years ago, all neoplastic cells within a tumour were suggested to have tumorigenic capacity, but recent evidences hint to the possibility that such feature is confined to a subset of Cancer Initiating Cells (CICs), also called Cancer Stem Cells (CSCs). These cells are the reservoir of the heterogeneous populations of differentiated cancer cells constituting the tumour bulk. Mechanisms shared with somatic stem cells, such as quiescence, self-renewal ability, asymmetric division and multidrug resistance, allow to these cells to drive tumour growth and to evade conventional therapy. Objective: Here, we give a brief overview on the origin of CICs, the mechanisms involved i…

Nuovi derivati 3,5-diaril-4,5-diidropirazolici come inibitori di HSP90

2008

Genetic Determined Downregulation of Both Type 1 and Type 2 Cytokine Pathways Might Be Protective against Pancreatic Cancer

2009

Many cytokine polymorphisms have been studied for associations with susceptibility to breast, gastric, liver, lung, prostate, and ovarian cancer without conclusive results. The cytokine network, indeed, is characterized by complex interactions, and the final biological effect of a single genetic variation depends on the balance among different molecular signals. As is well known, Th1/Th2 cytokine unbalanced production might predispose to different pathologies, cancer included. In general, a prolonged type 1 inflammatory response might allow that cells accumulating enough "genetic hits" are promoted to neoplastic transformation. On the other hand, IL-13-producing cells through the IL-13/IL-4…

Correction to: Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4 (Cell Death & Differentiation, (2008), 15, 4…

2019

We have only now noticed that in Fig. 3a, the immunohistochemical analysis of IL-4Rα on paraffin-embedded sections from breast is incorrect: IL-4 from breast was duplicated and used for the IL-4Rα staining. The correct Fig. 3a is given below.

IL-4-mediated drug resistance in colon cancer stem cells

2008

Cancer stem cells are defined as cells able to both extensively self-renew and differentiate into progenitors. Cancer stem cells are thus likely to be responsible for maintaining or spreading a cancer, and may be the most relevant targets for cancer therapy. The CD133 glycoprotein was recently described as a reliable cancer stem-like cell marker in colon carcinoma. CD133+ cells are both necessary and sufficient to initiate tumour growth in animal models. The CD133+ cell population and spheroid cultures contain cells expressing the stem cell marker Musashi-1 which is involved in maintenance of stem cell fate in several tissues and importantly, this expression is maintained in stem-like cells…

3,5-Diaizvietotu-4-fenil-2-pirolidonu un to strukturālo analogu sintēze

2017

5-Alkil-4-fenil-3-metilēn-2-pirolidonu un to strukturālo analogu sintēze. Baškevičs V., Darba vadītājs: Dr. ķīm. Maksims Vorona. Maģistra darbs. 102 lappuses, 18 attēli, 30 pielikumi, 32 literatūras avoti. Latviešu valodā. Uz Morita-Baylis-Hillman reakcijas produktu bāzes realizēta to acilēšana un nitroalkānu pievienošanas starpproduktam. Iegūtie starpprodukti tika pakļauti reducēšanas reakcijai un iekšmolekulārai ciklizācijai ar eksometilēn grupu saturošo 2-pirolidonu veidošanu. Šim nolūkam bija izmēģinātas vairākas literatūrā eksistējošas 5-alkil-4-fenil-3-metilēn-2-pirolidonu iegūšanas metodes, no kuriem tika izvēlēta reducēšanas reakcija ar dzelzs pulvera palīdzību ledus etiķskābē. Iegū…