Search results for "IMM"
showing 10 items of 18201 documents
Los marcos de interpretación de la violencia de género en las televisiones del Estado español. Modelos y tendencias
2012
<p>En los últimos años la violencia de género se ha convertido en un problema social de primera magnitud, cobrando especial atención los medios de comunicación por su responsabilidad en la construcción de realidades sociales. El objetivo de este artículo es analizar el tratamiento informativo de la violencia de género y su papel en la construcción de marcos de interpretación que dotan de significado el concepto de violencia de género. Para ello, se ha aplicado el análisis crítico del discurso a las noticias de cuatro televisiones del Estado español en la semana alrededor del Día Internacional contra la Violencia de Género de 2010.</p>
SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders
2022
Abstract Background The clinical efficacy of SARS-CoV-2 vaccines according to antibody response in immunosuppressed patients such as hematological patients has not yet been established. Patients and methods A prospective multicenter registry-based cohort study conducted from December 2020 to December 2021 by the Spanish transplant and cell therapy group was used to analyze the relationship of antibody response at 3–6 weeks after full vaccination (2 doses) with breakthrough SARS-CoV-2 infection in 1394 patients with hematological disorders. Results At a median follow-up of 165 days after complete immunization, 37 out of 1394 (2.6%) developed breakthrough SARS-CoV-2 infection at median of 77 …
Fundamentals on the Molecular Mechanism of Action of Antimicrobial Peptides
2019
Abstract Antimicrobial peptides (AMPs) are produced by several organisms as their first line of defense. Constituted by amino acids, they may present different mechanisms of action. The antimicrobial activity can be used by the peptide-producing organism itself, as innate immune strategy, or in the industry, applying as natural source preservatives. Understanding the possibilities of the operation of these compounds is a prerequisite for the development of effective uses, as well as for the establishment of combinations, which can even expand their applications considering the possibilities of genetic manipulations. Thus, the objective of this article is to review the basic principles of AM…
Thorough evaluation of OECD principles in modelling of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives using QSARINS.
2020
The human immunodeficiency virus is a lethal pathology considered as a worldwide problem. The search for new strategies for the treatment of this disease continues to be a great challenge in the scientific community. In this study, a series of 107 derivatives of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine, previously evaluated experimentally against HIV-I reverse transcriptase, was used to model antiretroviral activity. A model of linear regression, implemented in the QSARINS software, was developed with a genetic algorithm for variable selection. The fit of its parameters was good and exhaustive validation, according to the OECD regulatory principles, was performed. Also, the applica…
Fluorine-Containing Drugs Approved by the FDA in 2018
2019
Over the last two decades, fluorine substitution has become one of the essential structural traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster drugs) contain fluorine atoms. In this review, we profile 17 fluorine-containing drugs approved by the food and drug administration (FDA) in 2018. The newly approved pharmaceuticals feature several types of aromatic F and CF3 , as well as aliphatic (CF2 ) substitution, offering advances in the treatment of various diseases, including cancer, HIV, malarial and smallpox infections.
Herbicidal value of essential oils from oregano-like flavour species
2017
ABSTRACTChemical composition and phytotoxicity of oregano, marjoram and Thymus mastichina essential oils against Portulaca oleracea L., Lolium multiflorum Lam. and Echinochloa crus-galli (L.) Beauv. has been investigated. Seventy-seven compounds reaching 97.3% and 99.4% were identified by gas chromatography–mass spectrometry. Carvacrol (60.42 ± 0.07%), p-cymene (15.52 ± 0.02%) and γ-terpinene (5.19 ± 0.02%) were the main compounds in oregano essential oil, whereas large amounts of 1,8-cineol (59.59 ± 0.85%, 49.49 ± 0.37%), linalool (13.05 ± 0.04%, 5.66 ± 0.01%) and α-terpineol (3.36 ± 0.10%, 5.59 ± 0.01%), followed by β-pinene (4.35 ± 0.39, 5.54 ± 0.01%) and α-pinene (4.11 ± 0.53, 4.28 ± 0.…
Diabetes and renin-angiotensin-aldosterone system: Implications for covid-19 patients with diabetes treatment management
2020
In the context of the COVID-19 continuous spreading, this paper focuses on the increased risk of diabetic patients regarding the metabolic control and the uncertainties related to SARS-CoV-2 infection. Chronic hyperglycaemia negatively affects the immune system, which triggers an increase of morbidity and mortality for viral infections. A key aspect of COVID-19 resides in the involvement of renin-angiotensin-aldosterone (RAAS) system that causes a cascade of reactions mediated by vasoactive peptides with implications in vasoconstriction, vascular permeability, oxidative stress remodelling and tissue injuries. Activation of RAAS at pulmonary level, is responsible for the local damage. Many q…
Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts
2020
Background: Uncertainly continues to exist regarding the role of air pollution on pediatric asthma and allergic conditions, especially as air pollution levels have started to decrease in recent decades. Objective: We examined associations of long-term air pollution levels at the home address with pediatric eczema, rhinoconjunctivitis and asthma prevalences in five birth cohorts (BIB, EDEN, GASPII, RHEA and INMA) from seven areas in five European countries. Methods: Current eczema, rhinoconjunctivitis and asthma were assessed in children aged four (N = 6527) and eight years (N = 2489). A multi-morbidity outcome (≥2 conditions versus none) was also defined. Individual outdoor levels of nitrog…
A review of mental health and wellbeing under climate change in small island developing states (SIDS)
2021
AbstractSmall island developing states (SIDS) are often at the forefront of climate change impacts, including those related to health, but information on mental health and wellbeing is typically underreported. To help address this research lacuna, this paper reviews research about mental health and wellbeing under climate change in SIDS. Due to major differences in the literature’s methodologies, results, and analyses, the method is an overview and qualitative evidence synthesis of peer-reviewed publications. The findings show that mental health and wellbeing in the context of climate change have yet to feature prominently and systematically in research covering SIDS. It seems likely that m…
Understanding the Origins of Problem Geomagnetic Storms Associated with "Stealth" Coronal Mass Ejections.
2021
Geomagnetic storms are an important aspect of space weather and can result in significant impacts on space- and ground-based assets. The majority of strong storms are associated with the passage of interplanetary coronal mass ejections (ICMEs) in the near-Earth environment. In many cases, these ICMEs can be traced back unambiguously to a specific coronal mass ejection (CME) and solar activity on the frontside of the Sun. Hence, predicting the arrival of ICMEs at Earth from routine observations of CMEs and solar activity currently makes a major contribution to the forecasting of geomagnetic storms. However, it is clear that some ICMEs, which may also cause enhanced geomagnetic activity, cann…