Search results for "INJECTION"
showing 10 items of 920 documents
Physico-chemical stability of eribulin mesylate containing concentrate and ready-to-administer solutions.
2013
Objectives The aim of this study was to determine the stability of commercially available eribulin mesylate containing injection solution as well as diluted ready-to-administer solutions stored under refrigeration or at room temperature. Methods Stability was studied by a novel developed stability-indicating reversed-phase high-performance liquid chromatography (RP-HPLC) assay with ultraviolet detection (detection wavelength 200 nm). Triplicate test solutions of eribulin mesylate containing injection concentrate (0.5 mg/mL) and with 0.9% sodium chloride solution diluted ready-to-administer preparations (0.205 mg/mL eribulin mesylate in polypropylene (PP) syringes, 0.020 mg/mL eribulin mesyl…
The role of crystalline, mobile amorphous and rigid amorphous fractions in the performance of recycled poly (ethylene terephthalate) (PET)
2012
[EN] The action of thermo-mechanical degradation induced by mechanical recycling of poly(ethylene terephthalate) was simulated by successive injection moulding cycles. Degradation reactions provoked chain scissions and a reduction in molar mass mainly driven by the reduction of diethyleneglycol to ethylene glycol units in the flexible domain of the PET backbone, and the formation of -OH terminated species with shorter chain length. The consequent microstructural changes were quantified taking into account a three-fraction model involving crystalline, mobile amorphous (MAF) and rigid amorphous fractions (RAF). A remarkable increase of RAF, to a detriment of MAF was observed, while the percen…
Pharmakologisch-aktive polymere, 18. Körperverteilung und ausscheidungsverhalten von monomerem und polymerem sulfadiazinacrylamid
1979
Sulfadiazinacrylamid was absorbed after oral and intraperitoneal application in rats to a high extent; the absorption from the intraperitoneum was retarded. Glucose treatment delayed the absorption after both application forms. At comparatively high renal and enteral excretion rates the biological half life time of the monomer was estimated to 8 h. A tumouraffinity was not found but there were indications for a preferred storage in the RES. Poly[sulfadiazinacrylamide] was absorbed after intraperitoneal injection to a clear extent, where at the beginning of the treatment under simultaneous glucose load the absorption was delayed. 24 h after injection higher concentrations in metabolic organs…
Catalan words avoiding pairs of length three patterns
2021
Catalan words are particular growth-restricted words counted by the eponymous integer sequence. In this article we consider Catalan words avoiding a pair of patterns of length 3, pursuing the recent initiating work of the first and last authors and of S. Kirgizov where (among other things) the enumeration of Catalan words avoiding a patterns of length 3 is completed. More precisely, we explore systematically the structural properties of the sets of words under consideration and give enumerating results by means of recursive decomposition, constructive bijections or bivariate generating functions with respect to the length and descent number. Some of the obtained enumerating sequences are kn…
Tailored waveform generation in mode-locked fiber lasers by in-cavity pulse shaper
2014
International audience; We numerically show the possibility of pulse shaping in a mode-locked fiber laser by inclusion of an amplitude-phase spectral filter into the laser cavity. Various advanced temporal waveforms are generated, including parabolic, flat-top and triangular pulses.
Pulse shaping in mode-locked fiber lasers by in-cavity spectral filter
2014
International audience; We numerically show the possibility of pulse shaping in a passively mode-locked fiber laser by inclusion of a spectral filter into the laser cavity. Depending on the amplitude transfer function of the filter, we are able to achieve various regimes of advanced temporal waveform generation, including ones featuring bright and dark parabolic-, flat-top-, triangular- and saw-tooth-profiled pulses. The results demonstrate the strong potential of an in-cavity spectral pulse shaper for controlling the dynamics of mode-locked fiber lasers.
Flow-Injection Solid Phase Partial Least-Squares Spectrophotometric Simultaneous Determination of Iron, Nickel and Zinc
2002
A PLS-2 multivariate calibration method has been developed for the simultaneous determination of iron, nickel and zinc in ternary mixtures by solid phase spectrophotometry associated with flow injection analysis. Fe(II), Ni(II) and Zn(II) form color complexes with 1-(2-thiazolylazo)-2-naphthol (TAN), immobilized on a C18 bonded silica support, at pH 6.4. The proposed procedure is based on the different reaction/retention ratios of the studied ions on the solid support. Bilinear spectrophotometric data of the analytes, fixed in the solid support, were recorded in the 400-800 nm wavelength range as a function of time and a partial least squares (PLS-2) algorithm was used to predict results of…
Fluorimetric determination of captopril by flow injection analysis
1991
A flow injection analysis procedure is proposed for the determination of captopril. The sample solution was directly injected into the carrier-reagent stream which was prepared by a solution of ceric ions in 0.25 M sulfuric acid. The procedure is based on the fluorimetric monitoring of the formed Ce(III). Chemical, FIA, and instrumental parameters were optimized and the procedure is applied to the captopril determination in pharmaceutical formulations with competitive precision and adequate accuracy.
Flow-injection analysis study of the chemiluminescent behaviour of proflavine and acriflavine
2001
Abstract The chemiluminescent behaviour of the amino acridines like acriflavine, and proflavin is reported. Different strong oxidants (potassium permanganate, cerium(IV), hexacyanoferrate(III), hydrogen peroxide in different media) were tested, and potassium permanganate in sulphuric acid medium was selected. The study of the experimental parameters affecting the oxidation and detection was performed with the aid of a FIA assembly. The calibration graph was applied over the range 0.05–12.0 μg ml −1 of acriflavine (regression coefficient 0.9957, and the calculated relative standard deviation (R.S.D., %) was 0.9; LOD 10 ng ml −1 and the sample throughput 48 h −1 . The study of interfering com…
Standard addition method in FIA. Comparison between different assemblies
1999
A comparison between the different proposed methods to perform the standard addition in an on-line way (flow injection analysis) is made. The different assemblies (reverse and conventional FIA) and the employed standards in every method are compared. Three analyses were carried out, two of them were analyses of samples of pH indicators (methylorange and chlorophenol red) prepared at an acid pH, while the standards were prepared at a basic pH. The third analysis was the analysis of chloride in different synthetic waters with a perfectly known composition for all the ions present in the samples. Besides a new method to perform the on-line standard addition is proposed, trying to reduce the co…