Search results for "INTEGRAL"

2019

Integral membrane proteins of the aquaporin family facilitate rapid water flux across cellular membranes in all domains of life. Although the water-conducting pore is clearly defined in an aquaporin monomer, all aquaporins assemble into stable tetramers. In order to investigate the role of protomer–protomer interactions, we analyzed the activity of heterotetramers containing increasing fractions of mutated monomers, which have an impaired oligomerization propensity and activity. In order to enforce interaction between the protomers, we designed and analyzed a genetically fused homotetramer of GlpF, the aquaglyceroporin of the bacterium Escherichia coli (E. coli). However, increasing fractio…

On the continuous and discontinuous maximal operators

2018

Abstract In the first part of this paper we study the regularity properties of a wide class of maximal operators. These results are used to show that the spherical maximal operator is continuous W 1 , p ( R n ) ↦ W 1 , p ( R n ) , when p > n n − 1 . Other given applications include fractional maximal operators and maximal singular integrals. On the other hand, we show that the restricted Hardy–Littlewood maximal operator M λ , where the supremum is taken over the cubes with radii greater than λ > 0 , is bounded from L p ( R n ) to W 1 , p ( R n ) but discontinuous.

Biological insertion of computationally designed short transmembrane segments

2016

The great majority of helical membrane proteins are inserted co-translationally into the ER membrane through a continuous ribosome-translocon channel. The efficiency of membrane insertion depends on transmembrane (TM) helix amino acid composition, the helix length and the position of the amino acids within the helix. In this work, we conducted a computational analysis of the composition and location of amino acids in transmembrane helices found in membrane proteins of known structure to obtain an extensive set of designed polypeptide segments with naturally occurring amino acid distributions. Then, using an in vitro translation system in the presence of biological membranes, we experimental…

A Janus-Faced IM30 Ring Involved in Thylakoid Membrane Fusion Is Assembled from IM30 Tetramers.

2017

Summary Biogenesis and dynamics of thylakoid membranes likely involves membrane fusion events. Membrane attachment of the inner membrane-associated protein of 30 kDa (IM30) affects the structure of the lipid bilayer, finally resulting in membrane fusion. Yet, how IM30 triggers membrane fusion is largely unclear. IM30 monomers pre-assemble into stable tetrameric building blocks, which further align to form oligomeric ring structures, and differently sized IM30 rings bind to membranes. Based on a 3D reconstruction of IM30 rings, we locate the IM30 loop 2 region at the bottom of the ring and show intact membrane binding but missing fusogenic activity of loop 2 mutants. However, helix 7, which …

$\Omega$-symmetric measures and related singular integrals

2019

Let $\mathbb{S} \subset \mathbb{C}$ be the circle in the plane, and let $\Omega: \mathbb{S} \to \mathbb{S}$ be an odd bi-Lipschitz map with constant $1+\delta_\Omega$, where $\delta_\Omega>0$ is small. Assume also that $\Omega$ is twice continuously differentiable. Motivated by a question raised by Mattila and Preiss in [MP95], we prove the following: if a Radon measure $\mu$ has positive lower density and finte upper density almost everywhere, and the limit $$ \lim_{\epsilon \downarrow 0} \int_{\mathbb{C} \setminus B(x,\epsilon)} \frac{\Omega\left((x-y)/|x-y|\right)}{|x-y|} \, d\mu(y) $$ exists $\mu$-almost everywhere, then $\mu$ is $1$-rectifiable. To achieve this, we prove first that if …

Enhanced field-of-view integral imaging display using multi-Köhler illumination.

2014

A common drawback in 3D integral imaging displays is the appearance of pseudoimages beyond the viewing angle. These pseudoimages appear when the light rays coming from each elemental image are not passing through the corresponding microlens, and a set of barriers must be used to avoid this flipping effect. We present a pure optical arrangement based on Köhler illumination to generate these barriers thus avoiding the pseudoimages. The proposed system does not use additional lenses to project the elemental images, so no optical aberrations are introduced. As an added benefit, Köhler illumination provides a higher contrast 3D display. This work was supported in part by the Plan Nacional I + D …

On singular integral and martingale transforms

2007

Linear equivalences of norms of vector-valued singular integral operators and vector-valued martingale transforms are studied. In particular, it is shown that the UMD(p)-constant of a Banach space X equals the norm of the real (or the imaginary) part of the Beurling-Ahlfors singular integral operator, acting on the X-valued L^p-space on the plane. Moreover, replacing equality by a linear equivalence, this is found to be the typical property of even multipliers. A corresponding result for odd multipliers and the Hilbert transform is given.

On the existence of at least a solution for functional integral equations via measure of noncompactness

2017

In this article, we use fixed-point methods and measure of noncompactness theory to focus on the problem of establishing the existence of at least a solution for the following functional integral equation ¶ \[u(t)=g(t,u(t))+\int_{0}^{t}G(t,s,u(s))\,ds,\quad t\in{[0,+\infty[},\] in the space of all bounded and continuous real functions on $\mathbb{R}_{+}$ , under suitable assumptions on $g$ and $G$ . Also, we establish an extension of Darbo’s fixed-point theorem and discuss some consequences.

¿Es posible implantar programas de prevención en el medio escolar?

2003

Los profesores de un centro de formación profesional específica, entendiendo que su trabajo no tiene otra meta que la educación integral, asumen en su trabajo la preven¬ción para dotar a los educandos con capacidades, recursos y habilidades para la toma de sanas decisiones.En este artículo explican cómo desarrollan esta acción preventiva, que entienden cons¬ciente, sistemática, organizada y participativa, señalando las implicaciones de su incor¬poración a la red de las escuelas promotoras de salud.

Objetivos y efectos de la terapia a través del movimiento y el deporte con personas dependientes del alcohol

2006

Hoy en día la rehabilitación de personas dependientes del alcohol engloba un sistema integral e interdisciplinario de diferentes medidas médicas, psicoterapéuticas y socioterapéuticas. En Alemania la terapia a través del movimiento y el deporte ha llegado a estar integrada dentro del sistema rehabilitadora del tratamiento clínico de drogodependencias. A través del caso de Señor G. queremos explicar y aclarar como esta terapia puede contribuir al proceso terapéutico y qué resultados podemos esperar. Hacemos referencia tanto a las percepciones subjetivas del Señor G. como a las pruebas objetivas realizadas al inicio, durante y al final de la terapia a través del movimiento y el deporte. Concl…