Search results for "INTERVENTIONS"
showing 10 items of 300 documents
Spatio-temporal small area surveillance of the COVID-19 pandemic
2022
Abstract The emergence of COVID-19 requires new effective tools for epidemiological surveillance. Spatio-temporal disease mapping models, which allow dealing with small units of analysis, are a priority in this context. These models provide geographically detailed and temporally updated overviews of the current state of the pandemic, making public health interventions more effective. These models also allow estimating epidemiological indicators highly demanded for COVID-19 surveillance, such as the instantaneous reproduction number R t , even for small areas. In this paper, we propose a new spatio-temporal spline model particularly suited for COVID-19 surveillance, which allows estimating a…
Mapping 123 million neonatal, infant and child deaths between 2000 and 2017
2019
Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2—to end preventable child deaths by 2030—we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000–2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained ra…
Women in technology-oriented fields
2015
This study focuses on investigating the main elements that have an effect on women’s decisions to enter a career in technology-oriented fields, and more specifically, to discover whether studying crafts, especially technical work, during basic education affects their decisions in this context. The study was carried out using a semi-structured questionnaire, and the data consist of the responses from 12 female technology education teachers and 12 female engineering students. A qualitative theory oriented content analysis was carried out through identifying, coding, analysing and reporting the patterns within the data. The findings revealed that the most influential career anchor identified b…
L'intonaco Li Vigni nell'architettura del XX secolo a Palermo. Nuove conoscenze e applicazioni diagnostiche per la manutenzione
2013
Il saggio presenta lo studio degli intonaci formulati per imitare le pietre e i marmi naturali che si diffondono in Sicilia all’inizio del XX secolo ed evidenzia che le prime applicazioni e la diffusione delle nuove malte, anche nel resto dell’Italia, risentono delle sperimentazioni condotte in tutta l’Europa. Il contributo riassume i risultati di una rigorosa e capillare ricognizione tra i brevetti conservati presso l’Archivio Centrale dello Stato a Roma inerenti alle malte per il confezionamento dell’intonaco a “finta pietra”, ne analizza i contenuti in modo critico e pone in risalto i contatti culturali con le sperimentazioni dei materiali in atto nell’ambito dei grandi cantieri di resta…
Tommaso Maria Napoli Utriusque Architecturae Compendium Roma 1688 Breve trattato sulle fabbriche civili e militari e la conservazione delle architett…
2013
Il volume Tommaso Maria Napoli Utriusque Architecturae Compendium Roma 1688 Breve trattato sulle fabbriche civili e militari e la conservazione delle architetture del frate domenicano Tommaso Maria Napoli, vuole contribuire ad accrescere le nostre conoscenze sui principi che dovevano sottendere alla realizzazione dell’architettura civile e militare del periodo barocco e tardo barocco, così come espressi nel breve trattato scritto dal frate architetto, nato a Palermo, Tommaso Maria Napoli (1659-1725), e pubblicato a Roma alla fine del Seicento. Alla traduzione dal latino del trattato, redatta da esperti (Fabio Zarbo e Pietro Zarbo), è inclusa un’interessante ricerca, redatta congiuntamente c…
Giustizia ambientale e recupero delle aree verdi: il caso di Palermo
2021
L’urban shrinkage è diventata una questione centrale tanto nel dibattito scientifico quanto nell’agenda politica di diverse città europee. Secondo i dati EUROSTAT (2019), circa il 40% delle città europee con più di 200.000 abitanti stanno perdendo popolazione; una contrazione che si esplicita maggiormente, sotto il profilo spaziale, in una progressiva sottoutilizzazione del patrimonio edificato, così come nel contestuale incremento di aree e terreni in stato di abbandono. In questo quadro controverso di mutazione strutturale della città, così come l’abbiamo conosciuta, le politiche urbane alla prova in Europa tentano di declinare la decrescita quale occasione strategica di investimento sull…
Increasing Vaccine Acceptance and Uptake: A Review of the Evidence
2021
This article reviews the latest research on behavioral interventions to increase vaccine acceptance and uptake identifying the policies that work and underlying the determinants of their success. We focus primarily on studies that appeared after the publication of Brewer et al.’s (2017) in-depth survey of the behavioral literature on vaccination. We identify four major types of interventions that were tested in the lab, online or in the field: social norms-based interventions, opting-out strategies, reminders and recalls, and loss-framed/gain-framed messages (tailored to a particular population or not). Studies covered in this article can be a valuable resource to researchers as well as to …
Endothelin-1-Mediated Drug Resistance in EGFR-Mutant Non-Small Cell Lung Carcinoma.
2020
Abstract Progression on therapy in non-small cell lung carcinoma (NSCLC) is often evaluated radiographically, however, image-based evaluation of said therapies may not distinguish disease progression due to intrinsic tumor drug resistance or inefficient tumor penetration of the drugs. Here we report that the inhibition of mutated EGFR promotes the secretion of a potent vasoconstrictor, endothelin-1 (EDN1), which continues to increase as the cells become resistant with a mesenchymal phenotype. As EDN1 and its receptor (EDNR) is linked to cancer progression, EDNR-antagonists have been evaluated in several clinical trials with disappointing results. These trials were based on a hypothesis that…
Mental health and psychosocial support strategies in highly contagious emerging disease outbreaks of substantial public concern: A systematic scoping…
2021
Background Acute disease outbreaks such as the COVID-19 pandemic cause a high burden of psychological distress in people worldwide. Interventions to enable people to better cope with such distress should be based on the best available evidence. We therefore performed a scoping review to systematically identify and summarize the available literature of interventions that target the distress of people in the face of highly contagious disease outbreaks. Methods MEDLINE, Cochrane CENTRAL, Web of Science (January 2000 to May 7, 2020), and reference lists were systematically searched and screened by two independent reviewers. Quantitative and qualitative studies investigating the effects of psyc…