Search results for "IRM"
showing 10 items of 4043 documents
Strategic drivers influencing the governance of inter-firm relationships between biotechnology and pharmaceutical companies: an empirical survey
2010
This paper investigates the drivers influencing the choice of the governance form in inter-firm relationships (IFRs) between pharmaceutical and biotech companies. By analyzing the relevant literature on the issue, we have located the main drivers that might influence such relationship and a set of hypotheses linking them to governance forms. Such theoretical framework has been empirically tested through a survey conducted among the companies associated to Farmindustria. The result of the empirical analysis provides some interesting insights on how shaping bio-pharmaceutical deals; we found that the developmental stage of the product object of the deal, the existence of previous collaboratio…
Evaluation of proton MR spectroscopy at 3 Tesla without endorectal coil in patients with a localized prostate cancer treated with exclusive radiother…
2011
Prostate cancer is the most frequent tumour affecting the male population. When the prostate is not removed and is treated with radiation therapy, PSA slowly decreases over time to reach its nadir, even sometimes 18 to 24 months after the completion of radiation therapy without combined androgen suppression therapy. When combined with hormones, PSA falls abruptely with no possibility to perceive the impact of either hormones or radiation effects on PSA.The optimal value of PSA that should be reached after radiation therapy (nadir) and time to this nadir are still unclear.Even when a satisfactory value of the PSA nadir is reached, on-going variations of the PSA and its “bounce” effects, whic…
Factor analyses of multidimensional symptoms in a large group of patients with major depressive disorder, bipolar disorder, schizoaffective disorder …
2020
Abstract Background There is an ongoing discussion about which neurobiological correlates or symptoms separate the major psychoses (i.e. Major Depressive Disorder MDD, Bipolar Disorder BD, and Schizophrenia SZ). Psychopathological factor analyses within one of these disorders have resulted in models including one to five factors. Factor analyses across the major psychoses using a comprehensive set of psychopathological scales in the same patients are lacking. It is further unclear, whether hierarchical or unitarian models better summarize phenomena. Method Patients (n = 1182) who met DSM-IV criteria for MDD, BD, SZ or schizoaffective disorder were assessed with the SANS, SAPS, HAMA, HAM-D, …
Frequent and severe hypoglycaemia detected with continuous glucose monitoring in older institutionalised patients with diabetes.
2021
AbstractBackgroundLittle is known about the prevalence of hypoglycaemia in older people with diabetes. However, the HbA1c goal is ≥8% for institutionalised patients with treatments that can cause hypoglycaemia.PurposeWe aimed to assess the prevalence of hypoglycaemia with continuous glucose monitoring and to evaluate the link with HbA1C in older institutionalised patients with diabetes taking potentially hypoglycaemia-inducing drugs.DesignProspective, multicentre study carried out in six geriatric care centres in the Côte d’Or region of France between January 2019 and July 2020.Settings, subjects and methodsA FreeStyle Libre Pro® (FSLP) was worn for up to 14 days in blinded mode in 42 patie…
Glucose regulation and physical performance among older people: the Helsinki Birth Cohort Study
2018
Aims To assess whether disturbances in glucose regulation are associated with impairment in physical performance during a 10-year follow-up. Methods 475 Men and 603 women from the Helsinki Birth Cohort Study were studied. Glucose regulation was evaluated with a 2-h 75-g oral glucose tolerance test (OGTT) in 2001-2004. Subjects were categorised as having either impaired fasting glucose (IFG), impaired glucose tolerance (IGT), newly diagnosed diabetes or previously known diabetes. Physical performance was assessed approximately 10 years later using the validated senior fitness test (SFT). The relationship between glucose regulation and the overall SFT score was estimated using multiple linear…
Amyloid precursor protein in platelets: A peripheral marker for the diagnosis of sporadic AD
2001
BACKGROUND: An altered pattern of amyloid precursor protein (APP) forms consisting in a reduced ratio between the upper (130 kDa) and the lower (106 to 110 kDa) immunoreactivity bands has been described in platelets of patients with AD. OBJECTIVE: To evaluate the sensitivity and the specificity of platelet APP forms' ratio (APPr) as a marker for AD. METHODS: Eighty-five patients with probable AD and 95 control subjects (CON), including healthy individuals and neurologic patients, entered the study. Platelet APPr was evaluated by means of Western Blot analysis and immunostaining in the whole platelet homogenate, and calculated by the ratio between the optical density (OD) of the upper (130 k…
The Complex System Theory for the Analysis of Inter-Firm Networks: A Literature Overview and Theoretic Framework
2011
In this paper we discuss the body of knowledge known as complex system theory and its relevance to the analysis of inter-firm networks. We start by addressing the development of systems thinking. Through a literature overview, we point out the main elements for the development of systemic thought from its beginning, through its application in business sciences, to the birth of Complex Systems Theory (CST). With these initial annotations we provide an introduction to the concepts of the complex systems theory. We will underscore those aspects of CST that can be useful to analyze inter-firm networks, in order to highlight the evolutionary dynamics of the networks and to clarify the logical li…
Development and validation of the neighborhood environment walkability scale for youth across six continents
2019
Abstract Background The IPEN International Physical Activity and Environment Network Adolescent project was conducted using common study protocols to document the strength, shape, and generalizability of associations of perceived neighborhood environment attributes with adolescents’ physical activity and overweight/obesity using data from 15 countries. Countries did not use identical versions of the Neighborhood Environment Walkability Scale for Youth (NEWS-Y) to measure perceived neighborhood environment attributes. Therefore, this study derived a measurement model for NEWS-Y items common to all IPEN Adolescent countries and developed a scoring protocol for the IPEN Adolescent version of t…
Tēlotājdarbība burtu apguvei 3-4 gadus veciem bērniem pirmsskolā
2019
Kvalifikācijas darbu izstrādāja Ilze Belasa. Kvalifikācijas darba tēma ir “Tēlotājdarbība burtu apguvei 3-4 gadus veciem bērniem pirmsskolā”. Darba mērķis ir teorētiski noskaidrot un praktiski pārbaudīt, kā tēlotājdarbībā pirmsskolā sekmējama burtu apguve 3-4 gadus veciem bērniem. Lai sasniegtu šo mērķi tika izvirzīti uzdevumi: 1.Teorētiski analizēt literatūru par burtu apguvi. 2.Teorētiski analizēt literatūru par tēlotājdarbību pirmsskolā. 3.Teorētiski analizēt rotaļnodarbības pirmsskolā. 4.Pārbaudīt teorētiskās atziņas empīriskā pētījumā un analizēt iegūtos rezultātus. Pētījums sniegs ieskatu, kurš noderēs pedagoģiskajā darbā ar 3-4 gadu veciem bērniem, lai veiksmīgi sekmētu burtu apguvi …
Bērna radošās pašizpausmes attīstības iespējas vizuālajā mākslā pirmsskolā
2018
Kvalifikācijas darba temats: Bērna radošās pašizpausmes attīstības iespējas vizuālajā mākslā pirmsskolā. Darba autore: Tatjana Sirica Zinātniskā vadītāja: Rasma Purmale Kvalifikācijas darbs apjoms: 44 lpp., ietver 7 tabulas, 13 attēlus, izmantoti 53 literatūras avoti. Kvalifikācijas darbs izstrādāts ar mērķi teorētiski pētīt un empīriski pamatot vecākā pirmsskolas vecuma bērna radošās pašizpausmes sekmēšanas iespējas vizuālajā mākslā. Lai sasniegtu minēto mērķi, darba autore vispirms apkopojusi teorētiskos pētījumus, analizējot tādus jautājumus kā radošās pašizpausmes jēdziens, pašizpausmes attīstības nosacījumi, bērna vecumposma raksturojums, ka arī 5-6 gadus vecu bērnu radošās pašizpausme…