Search results for "Icing"

Automated transient hypertext support for software maintenance

2000

Preventing occupational injury among police officers: does motivation matter?

2017

Background: Injury prevention is an important issue for police officers, but the effectiveness of prevention initiatives is dependent on officers’ motivation toward, and adherence to, recommended health and safety guidelines. Aims: To understand effects of police officers’ motivation to prevent occupational injury on beliefs about safety and adherence to injury prevention behaviours. Methods: Full-time police officers completed a survey comprising validated psychometric scales to assess autonomous, controlled and amotivated forms of motivation (Treatment Self-Regulation Questionnaire), behavioural adherence (Self-reported Treatment Adherence Scale) and beliefs (Safety Attitude Questionnaire…

Photosensitive Alternative Splicing of the Circadian Clock Gene timeless Is Population Specific in a Cold-Adapted Fly, Drosophila montana

2018

DESIGN OF SF3B1 SUBUNIT MODULATORS OF THE SF3B SPLICEOSOME COMPLEX

2022

The subject of this dissertation is the search for new therapeutic strategies for pancreatic cancer and aims to implement a Drug Discovery process for the rational design and synthesis of molecules active in the modulation of pathways related to the regulation of pre-mRNA splicing process. This research project is the result of a joint PhD between the University of Palermo, Italy, and the Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands. It integrates complementary skills in pharmaceutical chemistry and translational cancer research with a special focus on the rational design of new anticancer compounds potentially active on SF3B1 (Splicing Factor 3B …

Una nuova mutazione di splicing del gene dell’ApoB responsabile di Ipobetalipoproteinemia Familiare in una paziente con steatosi epatica

2011

Stealth dicing with Bessel beams and beyond

2016

In the context of laser cutting of transparent materials, we investigate glass cleaving with Bessel beams and report that a modification of the beam with 3 main lobes drastically enhances cleavability and reduces defects.

Reduced Order Models for Pricing European and American Options under Stochastic Volatility and Jump-Diffusion Models

2017

Abstract European options can be priced by solving parabolic partial(-integro) differential equations under stochastic volatility and jump-diffusion models like the Heston, Merton, and Bates models. American option prices can be obtained by solving linear complementary problems (LCPs) with the same operators. A finite difference discretization leads to a so-called full order model (FOM). Reduced order models (ROMs) are derived employing proper orthogonal decomposition (POD). The early exercise constraint of American options is enforced by a penalty on subset of grid points. The presented numerical experiments demonstrate that pricing with ROMs can be orders of magnitude faster within a give…

Reduced Order Models for Pricing American Options under Stochastic Volatility and Jump-diffusion Models

2016

American options can be priced by solving linear complementary problems (LCPs) with parabolic partial(-integro) differential operators under stochastic volatility and jump-diffusion models like Heston, Merton, and Bates models. These operators are discretized using finite difference methods leading to a so-called full order model (FOM). Here reduced order models (ROMs) are derived employing proper orthogonal decomposition (POD) and non negative matrix factorization (NNMF) in order to make pricing much faster within a given model parameter variation range. The numerical experiments demonstrate orders of magnitude faster pricing with ROMs. peerReviewed

Selection of the Proper Revenue and Pricing Model for SaaS

2014

Recent research on software revenue and pricing models has revealed important ways in which firms can benefit from software renting. However, it is still unclear how SaaS providers select a proper revenue and pricing model to make their services attractive for customers. Based on 32 interviews with software professionals from four case firms, this study reveals how different factors impacted on the selection of a revenue and pricing model. It can be concluded that customers’ needs were the main driving force to the selection of the most appropriate pricing and revenue model in the market. peerReviewed

Violência, evasão e exclusão na educação superior

2019

The present text focuses on a relationship between higher education, institutional and symbolic violence and exclusion, practicing as a challenge based on reflections on the existence of evasion in Brazilian university. Ignoring the educational institution as a direct responsible for these things, this text considers that a logic in University organization and operation helps to enlarge inequalities that provide the mechanisms of evasion; at the same time, it presents itself as a space of reference and a struggle against social inequalities and violence. On a provisional basis, the text stands out that: depending on the execution of educational procedures and practices undertaken by the ins…