Search results for "Ileu"
showing 10 items of 244 documents
Antiinflammatory activity and effects on isolated smooth muscle of extracts from differentTeucrium species
1995
The present study analyses the antiinflammatory effects and the action on in vitro motility of methanol and dichloromethanol extracts and stems of four Teucrium species (T. flavum, T. cartaginenses, T. buxifolium and T. pumillum). The antiinflammatory activity was tested in the carrageenan-induced paw oedema in rats. T. flavum methanol (200 mg/kg, i.p.) and dichloromethanol (138 mg/kg, i.p.) extracts showed a significant anti-inflammatory effect through the 24 h experimental period and reduced the Emax induced by histamine and serotonin in vitro on guinea-pig ileum and rat uterus respectively. These extracts did not modify the contractile effects induced by acetylcholine on rat duodenum and…
In vitro pharmacological evaluation of the dichloromethanol extract fromSchinus molle l.
1998
The pharmacological activity of the dichloromethanol extract of Schinus molle L. (SM-DCM) was analysed in in vitro models. Preincubation of the isolated guinea-pig ileum or rat uterus preparations with the extract (100 μg/mL) abolished the contractile effects of histamine and serotonin respectively. At the same dose, the extract partially reduced the contractile effects of acetylcholine on the isolated rat duodenum. A 10 μg/mL dose showed an inhibitory effect on histamine and serotonin, but not on acetylcholine-induced contractions (NS). No significant effect was found with a 1 μg/mL dose. © 1998 John Wiley & Sons, Ltd.
Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice
2012
Background and purpose Gastrointestinal (GI) motility is regulated in part by fatty acid ethanolamides (FAEs), including the endocannabinoid (EC) anandamide (AEA). The actions of FAEs are terminated by fatty acid amide hydrolase (FAAH). We investigated the actions of the novel FAAH inhibitor AM3506 on normal and enhanced GI motility. Experimental approach We examined the effect of AM3506 on electrically-evoked contractility in vitro and GI transit and colonic faecal output in vivo, in normal and FAAH-deficient mice treated with saline or LPS (100 µg·kg(-1), i.p.), in the presence and absence of cannabinoid (CB) receptor antagonists. mRNA expression was measured by quantitative real time-PCR…
Die Hemmbarkeit der inhibitorischen Adrenalinbzw. Noradrenalinwirkung durch Adrenolytika
1958
Dibenamine, dihydroergotamine, regitin and priscol were found to antagonize specifically the inhibitory action of adrenaline and noradrenaline on the electrically stimulated isolated ileum of the guinea-pig. The antagonistic action of dibenamine was irreversible.
Der Antagonismus verschiedener Sympatholytica gegen�ber dem inhibitorischen Adrenalin- oder Noradrenalineffekt am elektrisch gereizten Meerschweinche…
1958
Adrenaline and noradrenaline were found to depress the contractions of the electrically stimulated isolated ileum of the guinea-pig; this action was related to the dose. In these experiments smaller amounts of adrenaline were required than those necessary for the depression of the spontaneous movements of the isolated rabbit duodenum.
Globularia alypumL. extracts reduced histamine and serotonin contractionin vitro
2002
The present study analyses in in vitro models the pharmacological activity of methanol and dichloromethane extracts (1, 10 and 100 microg/mL) obtained from the leaves and stems of Globularia alypum L. Preincubation of the guinea-pig ileum and rat uterus with both extracts produced a dose dependent abolition of the contractile effects of histamine and serotonin, respectively. At the same doses, neither methanol nor dichloromethane extract reduced the contractile effects of acetylcholine on rat duodenum or noradrenaline on rat vas deferens.
Implantable collamer lens and femtosecond laser for myopia: comparison using an adaptive optics visual simulator.
2014
Purpose: To compare optical and visual quality of implantable collamer lens (ICL) implantation and femtosecond laser in situ keratomileusis (F-LASIK) for myopia. Methods: The CRX1 adaptive optics visual simulator (Imagine Eyes, Orsay, France) was used to simulate the wavefront aberration pattern after the two surgical procedures for -3-diopter (D) and -6-D myopia. Visual acuity at different contrasts and contrast sensitivities at 10, 20, and 25 cycles/degree (cpd) were measured for 3-mm and 5-mm pupils. The modulation transfer function (MTF) and point spread function (PSF) were calculated for 5-mm pupils. Results: F-LASIK MTF was worse than ICL MTF, which was close to diffraction-limited MT…
Clinical use of the ocular point spread function for retinal image quality assessment
2008
The purpose of this study is to demonstrate the clinical use of the point spread function (PSF) as metric for the assessment of retinal image quality in eyes with different ocular conditions. The PSF was computed from the wavefront aberrations obtained in seven eyes with different ocular conditions: emmetropia, myopia, hyperopia, post-myopic laser in situ keratomileusis (LASIK), post-hyperopic LASIK, keratoconus, Intacs ® in keratoconus, radial keratotomy (RK), LASIK after RK, cataract, phacoemulsification after cataract surgery, and LASIK after astigmatic keratotomy. The Strehl intensity ratio was calculated for all the PSFs computed. The PSF was correlated with the change in the optical e…
Optical and visual quality comparison of implantable Collamer lens and laser in situ keratomileusis for myopia using an adaptive optics visual simula…
2012
Purpose. To compare optical and visual quality of the implantable Collamer lens (ICL) and laser in situ keratomileusis (LASIK) for myopia. Methods. An adaptive optics visual simulator (CRX1, Imagine Eyes, France) was used to simulate the vision after ICL implantation and LASIK procedure from the wavefront aberration pattern for -3 and -6 D. Monocular visual acuity (VA) at different contrasts and contrast sensitivity (CS) at 10, 20, and 25 cycles/degree (cpd) were measured for 3- and 5-mm pupils. Modulation transfer function (MTF) and point spread function (PSF) were calculated for a 5-mm pupil. Results. The ICL showed a MTF near of diffraction-limited MTF, but the post-LASIK of MTF worsened…
Development of polymer-based nanoparticles for Zileuton delivery to the lung : PMeOx and PMeOzi surface chemistry reduces interactions with mucins
2021
In this paper, two amphiphilic graft copolymers were synthesized by grafting polylactic acid (PLA) as hydrophobic chain and poly(2-methyl-2-oxazoline) (PMeOx) or poly(2-methyl-2-oxazine) (PMeOzi) as hydrophilic chain, respectively, to a backbone of α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA). These original graft copolymers were used to prepare nanoparticles delivering Zileuton in inhalation therapy. Among various tested methods, direct nanoprecipitation proved to be the best technique to prepare nanoparticles with the smallest dimensions, the narrowest dimensional distribution and a spherical shape. To overcome the size limitations for administration by inhalation, the nano-into-micr…