Search results for "Immune system"

Immunodefense in Tunicates: Cells and Molecules

2001

There are several reasons for analyzing tunicate immune systems. First, they can be established as primitive models for understanding fundamental immunological mechanisms by analyzing their individual cells and molecular products either in vivo or in vitro. Discovered mechanisms could provide alternatives to traditional (vertebrate) mammalian (mouse, rat) and emerging models (fish, amphibian reptile) in answering basic questions concerning immunity and disease in protochordates, the ancestors of vertebrates. Second in vitro, biochemical, immunochemical, and serological analyses coupled with molecular approaches are useful as we search for common molecules (e.g. markers of lymphocyte-like ce…

Immune Response ofDiscoglossus Pictus Pictusto a Protein Antigen

1974

Resistance of Cancer Stem Cells to Cell-Mediated Immune Responses

2015

In the past decades, the hierarchical organization of tumors, governed by Cancer Stem Cells (CSCs), have been reported with regard to several tumor types. Advances in sequencing technologies have demonstrated that diverse genetic CSCs subclones, derived from the branching evolution, compete with each other within the tumor mass, thereby contributing to the functional heterogeneity. It is becoming increasingly clear that epigenetic modifications and microenvironmental influences are important determinants of tumor fitness resulting in disease progression, recurrence and reduced patient survival. Therefore, more effective therapies will require gaining insights into the role of genetic and no…

Nanocarriers and immune cells

2019

Nanocarriers (NCs) have a high potential as target-specific drug-delivery system. Especially immune cells are a prime target in the nanoparticle-cell interaction. Uptake into the correct subtype of immune cells is crucial. Therefore uptake processes as well as intracellular processing is of utmost importance. The so-called protein corona heavily affects the interaction with immune cells which can decide the fate of the NC for degradation. On a wider perspective also nanoparticles which were not intentionally made for the transport of drugs get in contact with immune cells e.g. in the lungs. These immune cells are then trying to degrade these foreign materials.

The T-cell response in patients with cancer

2002

Publisher Summary The chapter examines several methods to measure human T-cell responses, including ELISPOT analysis, intracellular cytokine staining of immune cells after antigenic stimulation, limiting dilution analysis, conventional cloning, and molecular definition of the T-cell response either in the peripheral circulation or in situ in patients with cancer The chapter presents the cellular immune response in patients with cancer. The chapter explores the recent studies that suggest humoral immunity and T-cell-mediated immunity are closely linked. In addition, most of the data concerning antitumor immune responses have been generated using MHC class I tetramer reagents. The ultimate go…

Effects of Dietary Supplementation with Honeybee Pollen and Its Supercritical Fluid Extract on Immune Response and Fillet’s Quality of Farmed G…

2022

The awareness of the correlation between administered diet, fish health and products’ quality has led to the increase in the research for innovative and functional feed ingredients. Herein, a plant-derived product rich in bioactive compounds, such as honeybee pollen (HBP), was included as raw (HBP) and as Supercritical Fluid Extracted (SFE) pollen (HBP_SFE) in the diet for gilthead seabream (Sparus aurata). The experiment was carried out on 90 fish with an average body weight of 294.7 ± 12.8 g, divided into five groups, according to the administration of five diets for 30 days: control diet (CTR); two diets containing HBP at 5% (P5) and at 10% (P10) level of inclusion; two diet…

Correction to: Echinodermata: The Complex Immune System in Echinoderms

2018

Epidermal cytokines govern immune responses of the skin.

1998

Sa.33. Interleukin-7 Receptor (IL-7r) Mediated Signaling Effects in Immune Cells:Novel Readout for ‘Immune Competence’

2006

Interleukin-7

2003

This chapter discusses interleukin (IL)-7, which is an important lymphopoietin that plays a critical role in both B- and T-cell development. IL-7 promotes expansion of T lymphocytes exhibiting antigen-specific reactivity. IL-7 may be implemented to promote strong and effective immune responses against tumor cells, or directed against microbial or viral infections. It may also be useful in reconstituting an effective, and functional immune system after bone marrow transplantation, or helping to design novel strategies for immune reconstitution in patients with cancer or with HIV infection. IL-7 serves as the major growth and differentiation factor for both thymic and extrathymic development …