Search results for "Immunogen"
showing 10 items of 226 documents
Variabilidad genética y evolución del virus de la tristeza de los cítricos (CTV) en procesos de transmisión
2010
Los aislados de CTV están formados generalmente por una mezcla de variantes de secuencia, que se generan mediante procesos de mutación y recombinación. Su frecuencia en la población es el resultado de distintas presiones selectivas y de fenómenos de migración y deriva genética, generalmente asociados a los procesos de transmisión. El objetivo de esta tesis era analizar por separado el efecto de diversos factores de los procesos de transmisión sobre la estructura poblacional y la diversidad genética de distintos aislados del virus. Se analizó el efecto de la transmisión por pulgón. Ésta ocurrió con baja eficiencia y en general, las secuencias de los genes analizados en las plantas receptoras…
Foxp3 Silencing with Antisense Oligonucleotide Improves Immunogenicity of an Adjuvanted Recombinant Vaccine against Sporothrix schenckii
2021
Made available in DSpace on 2021-06-25T10:56:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background: In recent years, there has been great interest in developing molecular adjuvants based on antisense oligonucleotides (ASOs) targeting immunosuppressor pathways with inhibitory effects on regulatory T cells (Tregs) to improve immunogenicity and vaccine efficacy. We aim to evaluate the immunostimulating effect of 2′OMe phosphorothioated Foxp3-targeted ASO in an antifungal adjuvanted recombinant vaccine. Methods: The uptake kinetics of Foxp3 ASO, its cyto-toxicity and its ability to deplete Tregs were evaluated in…
Medical Research and Innovation
2021
This volume is dedicated to multidisciplinary research at the interface between basic biomedicine and clinical practice. This book guides best practice in the diagnosis and therapy while dealing with difficult-to-treat disorders of yet unclear etiology. Chapters address such disorders as granulomatosis with polyangiitis causing autoimmune-related multiorgan inflammation of blood vessels, increasingly widespread allergy to peanuts, occupational exposure to zinc oxide, and immunogenic responses to pneumococcal and influenza vaccination underlying their preventive effectiveness. Other hot issues deal with the proper use of fluid therapy in the perioperative period and a cognitive decline in lu…
2019
Abstract Type B Coxsackieviruses (CVBs) belong to the enterovirus genus, and they cause both acute and chronic diseases in humans. CVB infections usually lead to flu-like symptoms but can also result in more serious diseases such as myocarditis, aseptic meningitis and life-threatening multi-organ infections in young infants. Thus, CVBs have long been considered as important targets of future vaccines. We have previously observed CVB1 capsid disintegration and virus concentration decrease with 12-day long formalin inactivation protocol. Here a scalable ion exchange chromatography purification method was developed, and purified CVB1 was inactivated with UV-C or formalin. Virus morphology and …
HLA antigens in Sicilian patients affected by chronic myelogenous leukaemia.
1987
SUMMARY HLA antigens were investigated in Sicilian patients with chronic myelogenous leukaemia (CML) and in Sicilian healthy controls. The frequency of the HLA-DRw6 antigen was significantly decreased in the group of patients. These results suggest that DRw6 may be a marker for decreased susceptibility to the etiological or pathogenic mechanism(s) which produce CMLs.
Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data.
2001
Literature data suggest that human longevity may be directly correlated with optimal functioning of the immune system. Therefore, it is likely that one of the genetic determinants of longevity resides in those polymorphisms for the immune system genes that regulate immune responses. Accordingly, studies performed on mice have suggested that the Major Histocompatibility Complex (MHC), known to control a variety of immune functions, is associated with the life span of the strains. In the last 25 years, a fair number of cross-sectional studies that searched for the role of HLA (the human MHC) genes on human longevity by comparing HLA antigen frequencies between groups of young and elderly pers…
Sequence of rat cDNA clone pLR 112 coding for the RT1.D 1 chain
1990
Sistemas dopaminérgicos en el telencéfalo del ratón: Papel en el procesamiento de estímulos reforzantes naturales
2009
El refuerzo es un proceso psicológico complejo mediante el cual los animales modifican su comportamiento frente situaciones que les resultan ventajosas. Durante años se ha postulado que la dopamina (DA) liberada en el núcleo accumbens por neuronas tegmentales era el agente causal del refuerzo. Sin embargo, esta hipótesis es cada día más cuestionada y el refuerzo se subdivide en diversos procesos, sólo algunos de los cuales están relacionados con la DA. Utilizando el ratón como especie experimental, nos planteamos como objetivo comparar el papel de la DA en el refuerzo inducido por dos estímulos naturales diferentes. Utilizamos un reforzante ampliamente descrito, la sacarosa, frente un estím…
Análisis de las interacciones moleculares de la toxina Cry3Aa de Bacillus thuringiensis en la membrana del epitelio intestinal de Leptinotarsa deceml…
2011
Leptinotarsa decemlineata (escarabajo de la patata) es el insecto defoliador de patata de mayor importancia económica a nivel mundial, que también puede atacar otras plantas de interés económico como berenjena y tomate, y que ha desarrollado resistencia frente a un gran número de los insecticidas químicos utilizados para combatirlo. Las toxinas Cry de Bacillus thuringiensis, las cuales son altamente específicas para sus dianas e inocuas para los vertebrados, la gran mayoría de los invertebrados y las plantas, constituyen una herramienta de gran valor para el control de esta plaga, sin provocar efectos perjudiciales sobre el medio ambiente. En el presente trabajo hemos profundizado en el est…
Blood group does not appear to affect longevity a pilot study in centenarians from Western Sicily.
2011
Centenarians are the best example of extreme human longevity, and they represent a selected population in which the appearance of major age-related diseases, such as cancer, and cardiovascular diseases among others, has been consistently delayed or escaped. The study of the long-lived individual genetic profile has the purpose to possibly identify the genes and the allelic variations influencing extended life expectancy, hence considering them as biomarkers of age-related diseases onset and development. The present study shows no significant differences between allelic variations of ABO blood groups among a group of centenarians from Western Sicily.