Search results for "Indicators"

showing 10 items of 539 documents

Synthesis of a polymer-bound galactosylamine and its application as an immobilized chiral auxiliary in stereoselective syntheses of piperidine and am…

2004

A 2,3,4-tri-O-pivaloylated beta-D-galactopyranosyl azide bearing a hydroxy-functionalized spacer unit at the C-6 position of the galactose was synthesized and immobilized on the solid phase by using a polymer-bound chlorosilane. The azide was reduced to the corresponding galactopyranosylamine, which served as a versatile chiral auxiliary in highly diastereoselective Ugi four-component condensation reactions at ambient temperature. Fluoride-induced cleavage from the polymeric support furnished N-glycosylated N-acylated alpha-amino acid amides. The reaction of the immobilized galactosylamine with aldehydes gave rise to the corresponding aldimines, which underwent a domino Mannich-Michael cond…

Magnetic Resonance SpectroscopyDienePolymersMolecular ConformationGalactosamineCatalysisMass Spectrometrychemistry.chemical_compoundSolid-phase synthesisPiperidinesPolymer chemistryOrganic chemistryLewis acids and basesAmino AcidsChiral auxiliaryOrganic ChemistryDiastereomerStereoisomerismGeneral ChemistryCondensation reactionchemistryIndicators and ReagentsSpectrophotometry UltravioletAzidePiperidineChromatography Thin LayerChromatography LiquidChemistry (Weinheim an der Bergstrasse, Germany)
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Synthesis of Soluble Donor-Acceptor Double-Cable polymers based on polythiophene and tetracyanoanthraquinodimethane (TCAQ).

2003

[structure: see text] Novel suitably functionalized tetracyanoanthraquinodimethane (TCAQ) derivatives covalently linked to thiophene moieties have been synthesized. The thiophene-based monomers have been chemically polymerized and copolymerized to yield new and soluble donor-acceptor double-cable polymers. The absorption and emission data reveal that the optical properties can be finely tuned by modifying the ratio of monomers in the copolymerization process.

Magnetic Resonance SpectroscopyFotoricettoriPolymersAnthraquinonesThiophenesmacromolecular substancesBiochemistryIndicators and Reagentchemistry.chemical_compoundSpettroscopiaThiophenePolymer chemistryCopolymerThiophenePhysical and Theoretical ChemistryPolymerPolimerichemistry.chemical_classificationOrganic Chemistrytechnology industry and agriculturePolymerSettore CHIM/06 - Chimica OrganicaMonomerchemistryPolymerizationCovalent bondLuminescent MeasurementLuminescent MeasurementsPolythiopheneMolecular MedicineAnthraquinoneIndicators and ReagentsSpectrophotometry UltravioletAbsorption (chemistry)Celle solariSintesi
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Synthesis and evaluation of 2-tosylamino and 2-tosyliminopyrimidine derivatives as inhibitors of some leukocyte functions

2003

Abstract We have studied the potential anti-inflammatory effects of 20 2-tosylamino and 2-tosyliminopyrimidine new derivatives in human neutrophils. We have evaluated their interference with some leukocyte functions and 5-lipoxygenase activity. All the compounds reduced neutrophil degranulation process at concentrations in the μM range. Besides, compounds with a phenolic substitution inhibited leukotriene B 4 biosynthesis in neutrophils and decreased the cell-free 5-lipoxygenase activity. This study demonstrates that 2-tosylamino and 2-tosyliminopyrimidine derivatives can reduce the activation of neutrophil cells which may have relevance for the modulation of the inflammatory response.

Magnetic Resonance SpectroscopyNeutrophilsLeukotriene B4Inflammatory responseCell SeparationIn Vitro TechniquesLeukotriene B4Cell DegranulationTosyl Compounds2-tosyliminopyrimidinechemistry.chemical_compoundLipoxygenaseBiosynthesisDrug DiscoveryLeukocytesHumansLipoxygenase InhibitorsPharmacologychemistry.chemical_classificationArachidonate 5-LipoxygenasebiologyChemistryOrganic ChemistryElastaseGeneral MedicineIn vitroPyrimidinesEnzymeBiochemistryEnzyme inhibitorArachidonate 5-lipoxygenaseLeukotriene Bbiology.proteinNeutrophil degranulationIndicators and ReagentsLeukocyte ElastaseEuropean Journal of Medicinal Chemistry
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Synthesis and antileukemic activity of new 3-(1-phenyl-3-methylpyrazol-5-yl)-2-styrylquinazolin-4(3H)-ones.

2004

Abstract 3-(1-Phenyl-3-methylpyrazol-5-yl)-2-styrylquinazolin-4(3H)-ones 14a–q and 15a–q were synthesized by refluxing in acetic acid the corresponding 2-methylquinazolinones 12 and 13 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 14a–q and 15a–q were tested in vitro for their antileukemic activity against L1210 (murine leukemia), K562 (human chronic myelogenous leukemia) and HL60 (human leukemia) cell lines showing in some cases good activity.

Magnetic Resonance SpectroscopyStereochemistryHL60Pharmaceutical ScienceAntineoplastic AgentsHL-60 CellsAcetic acidchemistry.chemical_compoundStructure-Activity RelationshipDogshemic and lymphatic diseasesDrug Discoverymedicine3-(1-Phenyl-3-methylpyrazol-5-yl)-2-styrylquinazolin-4(3H)-oneAnimalsHumansLeukemia L1210LeukemiaGeneral Medicinemedicine.diseaseMolecular biologySettore CHIM/08 - Chimica FarmaceuticaIn vitroLeukemiachemistryCell cultureAntileukemic activityQuinazolinesIndicators and ReagentsBenzoic AldehydeK562 CellsCell DivisionChronic myelogenous leukemiaK562 cellsFarmaco (Societa chimica italiana : 1989)
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Choice of CTO scores to predict procedural success in clinical practice. A comparison of 4 different CTO PCI scores in a comprehensive national regis…

2021

Background We aimed to compare the performance of the recent CASTLE score to J-CTO, CL and PROGRESS CTO scores in a comprehensive database of percutaneous coronary intervention of chronic total occlusion procedures. Methods Scores were calculated using raw data from 1,342 chronic total occlusion procedures included in REBECO Registry that includes learning and expert operators. Calibration, discrimination and reclassification were evaluated and compared. Results Mean score values were: CASTLE 1.60±1.10, J-CTO 2.15±1.24, PROGRESS 1.68±0.94 and CL 2.52±1.52 points. The overall percutaneous coronary intervention success rate was 77.8%. Calibration was good for CASTLE and CL, but not for J-CTO…

MaleCalibraciónCardiovascular ProceduresPhysiologymedicine.medical_treatmentMyocardial InfarctionSocial SciencesVasos coronariosCardiovascular MedicineSeverity of Illness IndexPercutaneous coronary intervention:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Calibration [Medical Subject Headings]Learning and MemoryMedical ConditionsMedicine and Health SciencesPsychologyRegistries:Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings]Coronary Artery Bypass GraftingMultidisciplinaryQ:Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Cardiovascular Surgical Procedures::Vascular Surgical Procedures::Endovascular Procedures::Percutaneous Coronary Intervention [Medical Subject Headings]RIntervención coronaria percutáneaMiddle AgedPrognosisInterventional CardiologyClinical PracticeTreatment Outcome:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Health Status Indicators::Patient Acuity::Severity of Illness Index [Medical Subject Headings]Cardiovascular DiseasesIntegrated discrimination improvementArea Under CurveCohortCalibrationMedicineFemaleResearch ArticleLearning Curvesmedicine.medical_specialtyCoronary StentingScienceCardiologyMEDLINE:Check Tags::Male [Medical Subject Headings]Surgical and Invasive Medical ProceduresCoronary arteryRisk AssessmentTotal occlusionCalcificationPercutaneous Coronary InterventionmedicineHumansLearningRegistrosAged:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings]business.industryAngioplasty:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Assessment [Medical Subject Headings]Cognitive Psychology:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Area Under Curve [Medical Subject Headings]Biology and Life SciencesPercutaneous coronary intervention:Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Cardiovascular Disease Risk:Diseases::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Coronary Disease::Coronary Occlusion [Medical Subject Headings]Coronary Occlusion:Check Tags::Female [Medical Subject Headings]Stent ImplantationConventional PCIPhysical therapyCognitive Science:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings]National registry:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Registries [Medical Subject Headings]Physiological ProcessesbusinessCoronary AngioplastyNeuroscience
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High-performance liquid chromatography with fluorimetric detection in biological tissues of the 4-bromomethyl-7-methoxycoumarin ester derivative of 5…

1985

MaleChemical PhenomenaMetaboliteCarboxylic acidPeptideKidneyHigh-performance liquid chromatographyMicechemistry.chemical_compoundDrug StabilityAnimalsUmbelliferonesChromatography High Pressure LiquidBrain Chemistrychemistry.chemical_classificationChromatographyGeneral ChemistryGlutamic acid4-bromomethyl-7-methoxycoumarinPyrrolidinonesPyrrolidonecarboxylic AcidChemistrySpectrometry FluorescenceLiverchemistryIndicators and ReagentsDerivative (chemistry)Journal of Chromatography B: Biomedical Sciences and Applications
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Subtyping of group specific component (GC) in human semen, blood and vaginal fluid by isoelectric focusing in immobilized pH gradients.

1988

The group specific component (GC) is stable and well suited for forensic casework. Isoelectric focusing of common GC variants from semen, seminal fluid, vaginal fluid and semen stains, on Immobiline DryPlates, pH 4.5-5.4, is of practical value in criminal investigations of sexual deliquencies. GC is present in normospermia and azoospermia seminal fluids and found in about 20% of the vaginal secretions. The GC patterns observed were similar and in accordance with the bands of the individual GC type in plasma/serum.

MaleClinical BiochemistrySemenEnzyme-Linked Immunosorbent AssayBiologySemen analysisBiochemistryAnalytical ChemistrySemenmedicineHumansAzoospermiaImmunoassayChromatographymedicine.diagnostic_testIsoelectric focusingVitamin D-Binding ProteinHydrogen-Ion Concentrationmedicine.diseaseSubtypingImmunoassayGROUP-SPECIFIC COMPONENTVaginal fluidVaginaFemaleIndicators and ReagentsReagent Kits DiagnosticIsoelectric FocusingElectrophoresis
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Trends in health complaints from 2002 to 2010 in 34 countries and their association with health behaviours and social context factors at individual a…

2015

BACKGROUND: This article describes trends and stability over time in health complaints in adolescents from 2002 to 2010 and investigates associations between health complaints, behavioural and social contextual factors at individual level and economic factors at macro-level.METHODS: Comprising N = 510 876 11-, 13- and 15-year-old children and adolescents in Europe, North America and Israel, data came from three survey cycles of the international Health Behaviour in School-aged Children (HBSC) study. Age- and gender-adjusted trends in health complaints were examined in each country by means of linear regression. By using the country as the random effects variable, we tested to what extent in…

MalePediatricsmedicine.medical_specialtyAdolescentSocial Determinants of HealthHealth BehaviorMEDLINEsocial contextual factorshealth complaintshealth behaviourEnvironmental healthmedicineMacro levelHealth Status IndicatorsHumansadolescentsSocial determinants of healthIsraelChildAssociation (psychology)School age childeconomic factorsbusiness.industryEnvironmental and Occupational HealthPublic Health Environmental and Occupational HealthSocial environmentta3141ta3142Health SurveysEuropeAdolescent BehaviorNorth AmericaFemalePublic HealthHealth behaviorbusiness
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Reliability and Validity Study of the Finnish Adaptation of Scoliosis Research Society Questionnaire Version SRS-30

2017

Study design A prospective clinical study to test and adapt a Finnish version of the Scoliosis Research Society 30 (SRS-30) questionnaire. Objective The aim of this study was to perform cross-cultural adaptation and evaluate the validity of the adapted Finnish version of the SRS-30 questionnaire. Summary of background data The SRS-30 questionnaire has proved to be a valid instrument in evaluating health-related quality of life (HRQoL) in adolescent and adult population with spine deformities in the United States. Multinational availability requires cross-cultural and linguistic adaptation and validation of the instrument. Methods The SRS-30 was translated into Finnish using accepted methods…

MalePsychometricsIntraclass correlationRAND-36translationskolioosielämänlaatupatient outcome instrument0302 clinical medicineQuality of lifeScoliosis Research SocietySurveys and QuestionnairesMedicineHealth Status IndicatorsOrthopedics and Sports MedicineProspective StudiesOswestry disability indexFinlandreliabiliteetti030222 orthopedicsHealth Policyta3141Middle AgedOswestry Disability IndexScoliosisvalidointiCohortFemaleSpinal Diseasescross-cultural adaptationCross-Cultural Comparisonmedicine.medical_specialtyPsychometricsVisual analogue scalekyselytutkimusScoliosisHRQoL03 medical and health sciencesCronbach's alphaHumansSRS-30Agedreliabilitybusiness.industryadult spinal deformityFinnishPublic Health Environmental and Occupational HealthReproducibility of ResultsTranslatingmedicine.diseaseConfidence intervalvaliditeettiPhysical therapyQuality of LifeNeurology (clinical)business030217 neurology & neurosurgerySpine
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Discriminative and predictive properties of disease-specific and generic health status indexes in elderly COPD patients

2008

Abstract Background The association between bronchial obstruction severity and mortality in Chronic Obstructive Pulmonary Disease (COPD) is well established, but it is unknown whether disease-specific health status measures and multidimensional assessment (MDA) have comparable prognostic value. Methods We analyzed data coming from the Salute Respiratoria nell'Anziano (Respiratory Health in the Elderly – SaRA) study, enrolling elderly people attending outpatient clinics for respiratory and non-respiratory problems. From this population we selected 449 patients with bronchial obstruction (77.3% men, mean age 73.1). We classified patients' health status using tertiles of the Saint George Respi…

MalePulmonary and Respiratory MedicineDisease specificmedicine.medical_specialtyCopd patientsPulmonary diseaseSettore MED/10 - Malattie Dell'Apparato RespiratorioSeverity of Illness IndexPulmonary Disease Chronic ObstructiveDiscriminative modelForced Expiratory VolumeSeverity of illnessmedicineHealth Status IndicatorsHumansCOPDIntensive care medicineSurvival analysisAgedlcsh:RC705-779COPDbusiness.industrylcsh:Diseases of the respiratory systemPrognosismedicine.diseaseSurvival AnalysisFemaleGeriatric Depression ScalebusinessResearch Article
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