Search results for "Informatics"
showing 10 items of 2542 documents
Gene therapy for type 1 diabetes: is it ready for the clinic?
1999
This review, in addition to updating the growing list of type 1 diabetes- relevant gene therapies, offers an outline of short-term objectives that can readily be met to move, at least, adenoviral and adeno-associated viral-based protocols into the clinic, first as a means of facilitating islet allografts as well as platforms with which to introduce immunoregulatory transgenes. A wide array of genes have been tested to restore insulin production, to drive the differentiation of insulin-producing progenitors, and to confer immunosuppression in an antigen- and tissue-restricted manner.
Attenuated mucopolysaccharidosis: are you missing this debilitating condition?
2011
Liver fibrosis: Common mechanisms and antifibrotic therapies
2015
Liver fibrosis and in particular cirrhosis have become major endpoints in clinical trials of patients with chronic liver diseases. Here, viral hepatitis, alcoholic and non-alcoholic steatohepatitis have become the major etiologies. We have made great progress in our understanding of the mechanisms and the cell biology of liver fibrosis and have already made the transition from preclinical testing of antifibrotic agents and strategies towards clinical translation. There continues to be an urgent need for specific antifibrotic therapies, despite the advent of highly potent antiviral agents that can even induce regression of advanced fibrosis. This review addresses central mechanisms and cells…
Izšķirošās IKT izvēles nākamās digitālās dekādes robežšķirtnē Latvijas skolu izglītības politikas veidošanas sistēmā : promocijas darbs Vadības dokto…
2008
Darbā aplūkotas vairākas izšķirošas izvēles, kuras ir jāveic Latvijas izglītības sistēmai tuvākajos gados sakarā ar pasaules ieiešanu nākamajā digitālajā dekādē, ko pavada ne tikai būtiskas datoru infrastruktūras un lietojumu izmaiņas, bet arī pārmaiņas visā sabiedrībā kopumā, tajā skaitā vadības metodēs, koncepcijās un, līdz ar to arī izglītības sfērā un izglītības vadībā (IV) it īpaši. Darbs veltīts šo pārmaiņu teorētiskajai un praktiskajai bāzei, īpašu uzmanību pievēršot atklātā pirmkoda programmatūras (APP) lietošanas iespējām un aspektiem mācību procesā Latvijas skolās, galveno uzmanību pievēršot operētājsistēmu, biroja programmatūras un interneta risinājumu, tajā skaitā e-mācību, izvē…
ideal: an R/Bioconductor package for interactive differential expression analysis
2020
AbstractBackgroundRNA sequencing (RNA-seq) is an ever increasingly popular tool for transcriptome profiling. A key point to make the best use of the available data is to provide software tools that are easy to use but still provide flexibility and transparency in the adopted methods. Despite the availability of many packages focused on detecting differential expression, a method to streamline this type of bioinformatics analysis in a comprehensive, accessible, and reproducible way is lacking.ResultsWe developed the ideal software package, which serves as a web application for interactive and reproducible RNA-seq analysis, while producing a wealth of visualizations to facilitate data interpr…
Artificial increase of uracilemia during fluoropyrimidine treatment can lead to DPD deficiency misinterpretation
2021
Each year in France, >75 000 patients receive fluoropyrimidines, including 5-fluorouracil (5-FU) and its oral prodrug capecitabine (Xeloda), to treat digestive, breast and head and neck cancers.1 Among them, ∼20% will experience severe hematological and digestive toxicities and <2% will have a fatal outcome in the first two cycles. A part of these toxicities may result from a deficiency in dihydropyrimidine dehydrogenase (DPD) which catabolizes the endogenous uracil (U) into dihydrouracil (UH2) as well as 5-FU. In 2018, French Health Authorities [Haute Autorité de Santé (HAS) and Institut National du Cancer, (INCa)] recommended the evaluation of the enzymatic activity of DPD by measuring th…
A simple algorithm for generating neuronal dendritic trees
1990
Abstract A simple, efficient algorithm is presented for generating the codewords of all neuronal dendritic trees with a given number of terminal nodes. Furthermore, a procedure is developed for deciding if different codewords correspond to topologically equivalent trees.
Automated detection and localization system of myocardial infarction in single-beat ECG using Dual-Q TQWT and wavelet packet tensor decomposition.
2019
Abstract Background and objective It is challenging to conduct real-time identification of myocardial infarction (MI) due to artifact corruption and high dimensionality of multi-lead electrocardiogram (ECG). In the present study, we proposed an automated single-beat MI detection and localization system using dual-Q tunable Q-factor wavelet transformation (Dual-Q TQWT) denoising algorithm. Methods After denoising and segmentation of ECG, a fourth-order wavelet tensor (leads × subbands × samples × beats) was constructed based on the discrete wavelet packet transform (DWPT), to represent the features considering the information of inter-beat, intra-beat, inter-frequency, and inter-lead. To red…
Are the new genetic tools for diagnosis of Wilson disease helpful in clinical practice?
2020
Summary The diagnosis of Wilson disease is not always easy. For many patients, a combination of tests reflecting disturbed copper metabolism may be needed. Testing for ATP7B variants has become part of the routine diagnostic approach. The methods of genetic testing include analysis of the 21 coding exons and intronic flanking sequences, in which exons with recurrent variants would be prioritised depending on the mutation frequency in the local population. If sequencing the entire ATP7B gene cannot identify 2 variants and the suspicion for Wilson disease is high, after reviewing the clinical data, WES (whole-exome sequencing) or WGS (whole-genome sequencing) could be applied. A workflow base…