Search results for "Inulin"

Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

2014

This paper deal with the synthesis and characterization of PEGylated squalene-grafted-inulin amphiphile capable of self-assembling and self-organizing into nanocarriers once placed in aqueous media. It was exploited as coating agent for obtaining doxorubicin loaded superparamagnetic iron oxide nanoparticles (SPIONs) endowed with stealth like behavior and excellent physicochemical stability. Inulin was firstly modified in the side chain with primary amine groups, followed in turn by conjugation with squalenoyl derivatives through common amidic coupling agents and PEGylation by imine linkage. Polymer coated SPIONs were so obtained by spontaneous self-assembling of inulin copolymer onto magnet…

PREPARATION AND IN VITRO CHARACTERIZATION OF NEW HYDROGELS BASED ON INULIN AND ALPHA,BETA-POLYASPARTYLHYDRAZIDE FOR COLONIC DRUG DELIVERY

2008

SIMPLE, BIOCOMPATIBLE AND COST-EFFECTIVE INULIN BASED SIRNA DELIVERY SYSTEMS

2014

Inulin-Spermine derivatives for siRNA delivery

2014

pH responsive polycation inulin derivative for siRNA Delivery

2015

Bakteriālo levānu kvantitatīvās noteikšanas metodes izstrāde

2017

Bakteriālais levāns (BL) ir ekstracellulārs fruktozes polimērs ar ievērojamu tehnoloģisko potenciālu. Tā realizāciju veicina efektīvu producentu meklējumi un fermentācijas procesu optimizācija, bet kavē specifisku, precīzu un viegli īstenojamu BL noteikšanas metožu trūkums. Maģistra darbā, balstoties uz inulīna enzimātiskās noteikšanas metodi (K-RFUC, Megazyme), skaidroti dažādas izcelsmes endo- un ekso-inulināžu daudzumi, attiecības, reakcijas apstākļi (temperatūra, laiks), kas nodrošina BL pilnu hidrolīzi un kvantitatīvu noteikšanu. Modificētās K-FRUC metodes pārbaude BL standartšķīdumos un validācija ar standartpiedevu metodi producenta Gluconobacter nephelii kultūršķidrumos (BL atgūstam…

Production of functional probiotic, prebiotic, and synbiotic ice creams

2010

In this work, 3 types of ice cream were produced: a probiotic ice cream produced by adding potentially probiotic microorganisms such as Lactobacillus casei and Lactobacillus rhamnosus; a prebiotic ice cream produced by adding inulin, a prebiotic substrate; and a synbiotic ice cream produced by adding probiotic microorganisms and inulin in combination. In addition to microbial counts, pH, acidity, and physical and functional properties of the ice creams were evaluated. The experimental ice creams preserved the probiotic bacteria and had counts of viable lactic acid bacteria, after frozen storage that met the minimum required to achieve probiotic effects. Moreover; most of the ice creams show…

INULIN GRAFT CO-POLYMERS AS SELF-ASSEMBLING MICELLES FOR DRUG DELIVERY

2014

DIFFERENTIAL SCANNING CALORIMETRY STUDY ON DRUG RELEASE FROM AN INULIN-BASED HYDROGEL AND ITS INTERACTION WITH A BIOMEMBRANE MODEL:pH AND LOADING EFF…

2008

Inulin has been derivatized with methacrylic anhydride (MA) and succinic anhydride (SA) to obtain a methacrylated/succinilated derivative (INU-MA-SA) able to produce a pH sensitive hydrogel after UV irradiation. The hydrogel was characterized and loaded with diflunisal (10.4, 17 and 24%, w/w) chosen as a model drug. The drug release from INU-MA-SA-based hydrogel to a biomembrane model made by unilamellar vesicles of dimyristoylphosphatidyl-choline (DMPC) was investigated at pH 4.0 and 7.4 by differential scanning calorimetry (DSC) that appears to be a suitable technique to follow the transfer kinetics of a drug from a controlled release system to a biomembrane model. The drug release from t…

Inulin-iron complexes: a potential treatment of iron deficiency anaemia.

2007

The aim of this work was that to synthesize macromolecular derivatives based on inulin able to complex iron and useful in the treatment of iron deficiency anaemia. Carboxylated or thiolated/carboxylated inulin derivatives were obtained by single or double step reactions, respectively. The first one was obtained by reaction of inulin (INU) with succinic anhydride (SA) alone obtaining INU-SA derivative; the second one was obtained by the reaction of INU with succinic anhydride and subsequent reaction of INU-SA with cysteine; both derivatives were treated with ferric chloride in order to obtain the INU-SA-Fe(III) and INU-SA-Cys-Fe(III) complexes. Both complexes showed an excellent biodegradabi…