Search results for "Isolation"
showing 10 items of 582 documents
Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice.
2021
Abstract The impact of stressful events is especially important during early life, because certain cortical regions, especially the prefrontal cortex (PFC), are still developing. Consequently, aversive experiences that occur during the peripubertal period can cause long-term alterations in neural connectivity, physiology and related behaviors. Although sex influences the stress response and women are more likely to develop stress-related psychiatric disorders, knowledge about the effects of stress on females is still limited. In order to analyze the long-term effects of peripubertal stress (PPS) on the excitatory and inhibitory circuitry of the adult PFC, and whether these effects are sex-d…
Post-weaning social isolation rearing influences the expression of molecules related to inhibitory neurotransmission and structural plasticity in the…
2012
Several lines of evidence indicate that alterations in the structure of neural circuits and inhibitory neurotransmission underlie the physiopathogenesis of schizophrenia. Most of the studies on these parameters have been focused on cortical regions and, despite the crucial role of the amygdala in this psychiatric disorder, there is less information on this region. In order to expand this knowledge, we have studied the expression of molecules related to inhibitory neurotransmission and structural plasticity in rats subjected to post-weaning isolation rearing, an animal model that reproduces several core symptoms of schizophrenia. We have analyzed, using qRT-PCR and immunohistochemistry, the …
Comparative study on enzymatic activity and molecules stability of some commercial proteolytic enzymes used in pancreatic islet isolation.
2009
In pancreatic islets purification, for cell therapy applications, the major enzymes used are obtained from Clostridium hystoliticum; class I and class II collagenases (COLL G and COLL H). They are used in a defined tissue dissociation enzyme (TDE) mixtures together neutral protease (Dispase) or thermolysin (Thermostable Neutral Protease). The TDE mixtures were in part responsible for the success of the Edmonton protocol; however, just to now, people working in islets purification found discrepancy in an application to another one. This variability in application see in the enzymatic blend composition the higher accused, such as the contamination from endotoxines due to extractive production…
Investigation of the DEMO WCLL Breeding Blanket Cooling Water Activation
2020
Abstract Within the framework of the activities foreseen by the EUROfusion action on the cooling water activation assessment for a DEMO reactor equipped with a Water Cooled Lithium Lead Breeding Blanket (WCLL BB), the University of Palermo is involved in the assessment of dose rates induced by the decay of nitrogen radioisotopes produced by water activation, nearby the main components (e.g. isolation valves) of both First Wall (FW) and Breeder Zone (BZ) cooling circuits. In particular, the aim of this work is to evaluate the spatial distribution of nitrogen isotopes (16N and 17N) in the WCLL BB cooling circuits. To this purpose, a coupled neutronic/fluid-dynamic problem is solved following …
Nontraditional configuration of tuned liquid column damper inerter for base-isolated structures
2023
In this paper, the concept of a novel passive control device, namely the Nontraditional Tuned Liquid Column Damper Inerter (NT-TLCDI), is investigated in combination with seismic base isolation (BI), to control lateral displacement demands in base-isolated structures during seismic events. The considered NT-TLCDI is a revision of the ordinary configuration of the recently proposed Tuned Liquid Column Damper Inerter (TLCDI). Unlike the traditional TLCDI layout, which involves a secondary liquid mass in a U-shaped tank coupled with a grounded inerter and connected to the isolation system by a spring-dashpot system, in the NT-TLCDI configuration, the damper is in parallel with the inerter rath…
BYSTANDERS IN THE SCHOOL VIOLENCE SITUATIONS FROM THE PUPIL PERSPECTIVE
2021
Bullying rarely takes place between two individuals in isolation, usually, it occurs with pupil’s bystanders present. How often pupils take the role of bystander, what bystanders usually do in the bullying situation and how it can be explained was examined with 5003 pupils attending 55 Latvia’s schools. Responses indicated that more than a third (n=1913) of all respondents admitted that they had been in a situation where they witnessed another pupil being bullied. After analyzing the responses of those respondents, was concluded that although the majority of pupils felt bad about it, most did nothing about it or did not consider the situation important for involvement. This could be explain…
Sample pretreatment techniques for oligopeptide analysis from natural sources
2008
The analysis of oligopeptides in samples of food, tissues, and body fluids attracts considerable attention. The complexity of such samples requires efficient sample preparation (i.e., concentration and cleanup) procedures to remove interfering endogenous compounds and inorganic or organic salts. The methods of sample pretreatment that enable effective and selective isolation and/or preconcentration of oligopeptides from complex sample matrices have been reviewed. In each case, examples of application were presented and discussed, taking into account selectivity, enrichment, method automation, cleanup, and environmental aspects of the developed methods.
On the optimal design of base isolation devices
2013
The paper deals with the optimal design of a base isolation system for a given structure subjected to seismic loads. In particular, an appropriate minimum displacement seismic protection device optimal design formulation is proposed for an assigned elastic perfectly plastic steel frame constrained to behave in conditions of elastic shakedown. The chosen base isolation device is constituted by elastomeric isolators. Suitable combinations of fixed and seismic loads are considered. According to the unrestricted shakedown theory, the seismic input is given as any load history appertaining to a suitably defined seismic load admissibility domain. The relevant dynamic structural response is obtain…
Earthquake Excited Base-Isolated Structures Protected by Tuned Liquid Column Dampers: Design Approach and Experimental Verification
2017
Abstract In this contribution a direct approach for optimal design of a Tuned Liquid Column Damper (TLCD) device attached to the base slab of a base-isolated structure is presented, aiming at reducing the seismic displacement demand of the base-isolation subsystem. Assuming white noise base excitation, for a wide parameter range a direct optimization procedure yields design charts for optimal TLCD quantities. The performance of the base-isolated structure equipped with optimally tuned TLCD device in comparison to the simple base-isolated one is evaluated both numerically and experimentally. In a numerical study the system is subjected to the 44 records of the FEMA P-695 far-field ground mot…
Hybrid Passive Control Strategies for Reducing the Displacements at the Base of Seismic Isolated Structures
2019
In this paper, the use of hybrid passive control strategies to mitigate the seismic response of a base-isolated structure is examined. The control performance of three different types of devices used for reducing base displacements of isolated buildings is investigated. Specifically, the Tuned Mass Damper (TMD), the New Tuned Mass Damper (New TMD) and the Tuned Liquid Column Damper (TLCD), each one associated to a Base Isolated structure (BI), have been considered. The seismic induced vibration control of base-isolated structures equipped with the TMD, New TMD or the TLCD is examined and compared with that of the base-isolated system without devices, using real recorded seismic signals as e…