Search results for "Journal"
showing 10 items of 1472 documents
Charles Nodier, Trilogie écossaise
2013
Charles Nodier’s summer ambulations through Scotland in 1821 were to spawn a genre: the romantic travelogue. The reader is invited on a journey through age-old legends and oneiric cartography, through the fogs of ancient Caledonia and modern Scotland, and into the land of goblins and fairies.
Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000-17: analysis for th…
2020
Background: Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat disease. Identifying subnational regions with the highest burden and mapping associated risk factors can aid in reducing preventable childhood diarrhoea. Methods: We used Bayesian model-based geostatistics and a geolocated dataset comprising 15 072 746 children younger than 5 years from 466 surveys in 94 LMICs, in combination with findings of the Global Burden of Diseases, Injuri…
De L’Auto à L’Équipe : une histoire politique à dimension internationale (1932-1952)
2020
Cet article reprend l’exposé de la soutenance de la thèse De L’Auto à L’Équipe : une histoire politique à dimension internationale (1932-1952), soutenue par Tom Busseuil à l’université de Bourgogne, le 30 juin 2020; International audience
"TV- uutiset yhä kruununjalokivi" : MTV:n televisiouutisten muutos vuosina 2007-2015
2016
Media on kokenut 2000-luvun aikana useita muutoksia ja murroskausia. Verkkosisältöjen ja mobiilijournalismin merkityksen kasvu on asettanut perinteiset mediatalot uuteen tilanteeseen. Erilaisten julkaisualustojen väliset rajaaidat ovat kaventuneet. Samaan aikaan toimittajan työhön liittyvät ammatilliset vaatimukset ovat kasvaneet. Tässä tutkielmassa pyritään selvittämään, miten median konvergenssi ja siihen kytkeytyvät ilmiöt ovat muuttaneet yhden uutistoimituksen, MTV:n uutistoimituksen, toimintamalleja. Tutkielmassa tarkastellaan, kuinka MTV:n television pääuutislähetykset ovat muuttuneet vuosina 2007–2015. Lisäksi tutkielmassa pyritään selvittämään, missä määrin median konvergenssi on va…
DERECHOS, ESCEPTICISMO Y MAYORITARISMO: UN TRIÁNGULO IMPOSIBLE. UNA CRÍTICA A LA TEORÍA DE LA LEGITIMIDAD POLÍTICA DE JEREMY WALDRON
2019
El trabajo reconstruye y analiza críticamente la respuesta de Jeremy Waldron a importantes problemas sobre política y derecho, justicia y autoridad. Waldron reivindica al mismo tiempo una tesis no escéptica sobre la existencia los derechos morales-políticos, una tesis escéptica sobre la existencia de procedimientos epistémicos superiores para identificarlos, y una tesis positiva sobre la legitimidad política (mayoritarismo participativo). El trabajo argumenta que su respuesta solo resulta consistente si se añade un cuarto vértice: el presupuesto de “igualdad de agencia y capacidad epistémica” en los portadores de derechos. Pero su introducción requiere abandonar y redefinir dos de los otros…
Extranodal extension of lymph node metastasis influences recurrence in prostate cancer: a systematic review and meta-analysis
2017
AbstractThe extranodal extension (ENE) of nodal metastasis involves the extension of neoplastic cells through the lymph node capsule into the perinodal adipose tissue. This morphological feature has recently been indicated as an important prognostic factor in various cancer types, but its role in prostate cancer is still unclear. We aimed to clarify it, performing the first meta-analysis on this issue, comparing prognostic parameters in surgically treated, node-positive prostate cancer patients with (ENE+) vs. without (ENE−) ENE. Data were summarized using risk ratios (RRs) for number of deaths/recurrences and hazard ratios (HRs), with 95% confidence intervals (CI), for the time-dependent r…
High Rate of Recurrent De Novo Mutations in Developmental and Epileptic Encephalopathies
2017
Item does not contain fulltext Developmental and epileptic encephalopathy (DEE) is a group of conditions characterized by the co-occurrence of epilepsy and intellectual disability (ID), typically with developmental plateauing or regression associated with frequent epileptiform activity. The cause of DEE remains unknown in the majority of cases. We performed whole-genome sequencing (WGS) in 197 individuals with unexplained DEE and pharmaco-resistant seizures and in their unaffected parents. We focused our attention on de novo mutations (DNMs) and identified candidate genes containing such variants. We sought to identify additional subjects with DNMs in these genes by performing targeted sequ…
NBEA : developmental disease gene with early generalized epilepsy phenotypes
2018
Abstract: NBEA is a candidate gene for autism, and de novo variants have been reported in neurodevelopmental disease (NDD) cohorts. However, NBEA has not been rigorously evaluated as a disease gene, and associated phenotypes have not been delineated. We identified 24 de novo NBEA variants in patients with NDD, establishing NBEA as an NDD gene. Most patients had epilepsy with onset in the first few years of life, often characterized by generalized seizure types, including myoclonic and atonic seizures. Our data show a broader phenotypic spectrum than previously described, including a myoclonic-astatic epilepsy-like phenotype in a subset of patients. Ann Neurol 2018;84:796-803
Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
2016
Background BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs). Methods We characterised the pathologic features of 419 BRCA1/2 MBCs and, using logistic regression analysis, contrasted those with data from 9675 BRCA1/2 FBCs and with population-based data from 6351 MBCs in the Surveillance, Epidemiology, and End Results (…
Fried potato consumption is associated with elevated mortality: an 8-y longitudinal cohort study
2017
Background: Few studies have assessed the association between potato consumption and mortality. Objective: We investigated whether potato consumption (including fried and unfried potatoes) is associated with increased premature mortality risk in a North American cohort. Design: A longitudinal analysis included 4440 participants aged 45-79 y at baseline with an 8-y follow-up from the Osteoarthritis Initiative cohort study. Potato consumption (including fried and unfried potatoes) was analyzed by using a Block Brief 2000 food-frequency questionnaire and categorized as ≤1 time/mo, 2-3 times/mo, 1 time/wk, 2 times/wk, or ≥3 times/wk. Mortality was ascertained through validated cases of death. T…