Search results for "L10"
showing 10 items of 79 documents
A Koebe distortion theorem for quasiconformal mappings in the Heisenberg group
2017
We prove a Koebe distortion theorem for the average derivative of a quasiconformal mapping between domains in the sub-Riemannian Heisenberg group $\mathbb{H}_1$. Several auxiliary properties of quasiconformal mappings between subdomains of $\mathbb{H}_1$ are proven, including distortion of balls estimates and local BMO-estimates for the logarithm of the Jacobian of a quasiconformal mapping. Applications of the Koebe theorem include diameter bounds for images of curves, comparison of integrals of the average derivative and the operator norm of the horizontal differential, as well as the study of quasiconformal densities and metrics in domains in $\mathbb{H}_1$. The theorems are discussed for…
Uniformization of metric surfaces using isothermal coordinates
2021
We establish a uniformization result for metric surfaces - metric spaces that are topological surfaces with locally finite Hausdorff 2-measure. Using the geometric definition of quasiconformality, we show that a metric surface that can be covered by quasiconformal images of Euclidean domains is quasiconformally equivalent to a Riemannian surface. To prove this, we construct suitable isothermal coordinates.
Metric equivalences of Heintze groups and applications to classifications in low dimension
2021
We approach the quasi-isometric classification questions on Lie groups by considering low dimensional cases and isometries alongside quasi-isometries. First, we present some new results related to quasi-isometries between Heintze groups. Then we will see how these results together with the existing tools related to isometries can be applied to groups of dimension 4 and 5 in particular. Thus we take steps towards determining all the equivalence classes of groups up to isometry and quasi-isometry. We completely solve the classification up to isometry for simply connected solvable groups in dimension 4, and for the subclass of groups of polynomial growth in dimension 5.
IP-10 is an accurate biomarker for the diagnosis of tuberculosis in children.
2014
Summary Objective Performance of IFN-γ assays in children is compromised. Therefore, we investigated the utility of IP-10 for the detection of active tuberculosis (TB) and latent tuberculosis infection (LTBI) diagnosis in children; comparing its positivity with QuantiFERON-TB Gold In-Tube (QFN-G-IT) and T-SPOT.TB. Methods We studied 230 children from three groups: active TB, screening (healthy children without known exposure to active TB patient screened at school or by their paediatrician) and contact-tracing studies. IFN-γ release was determined by QFN-G-IT and T-SPOT.TB. IP-10 was detected in QFN-G-IT supernatants by ELISA. Results When combining QFN-G-IT and IP-10 assays, positive resul…
CXCR3-ligand-mediated skin inflammation in cutaneous lichenoid graft-versus-host disease.
2007
Background Lichenoid graft-versus-host disease (liGVHD) histologically shares several common features with other lichenoid dermatoses, such as cutaneous lupus erythematosus and lichen planus (LP), which collectively show a junctional infiltrate of cytotoxic lymphocytes with liquefaction of the basal layer ("interface dermatitis"). Because recent studies have shown a role for type I interferon (IFN)–associated inflammation, including lymphocyte recruitment via CXCR3 ligand interaction in cutaneous lupus erythematosus and LP, we hypothesized that similar mechanisms might also be involved in liGVHD. Methods Ten representative lesional skin biopsies taken from patients with different subsets of…
Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
2014
International audience; The immune system is routinely confronted with cell death resulting from the physiological turnover of renewable tissues, as well as from pathological insults of several types. We hypothesize the existence of a mechanism that allows the immune system to discriminate between physiological and pathological instances of cell death, but the factors that determine whether cellular demise is perceived as a neutral, tolerogenic or immunogenic event remain unclear 1. Infectious insults are accompanied by so-called microbe-associated molecular patterns (MAMPs), i.e., viral or bacterial products that activate immune cells through a panel of pattern-recognition receptors (PRRs)…
Bortezomib induction, reduced-intensity transplantation, and lenalidomide consolidation-maintenance for myeloma: updated results.
2013
A sequential approach including bortezomib induction, intermediate-dose melphalan, and autologous stem cell transplantation (ASCT), followed by lenalidomide consolidation-maintenance, has been evaluated. Efficacy and safety data have been analyzed on intention-to-treat and results updated. Newly diagnosed myeloma patients 65 to 75 years of age (n = 102) received 4 cycles of bortezomib-pegylated liposomal doxorubicin-dexamethasone, tandem melphalan (100 mg/m(2)) followed by ASCT (MEL100-ASCT), 4 cycles of lenalidomide-prednisone consolidation (LP), and lenalidomide maintenance (L) until disease progression. The complete response (CR) rate was 33% after MEL100-ASCT, 48% after LP and 53% after…
Ganodermycin, a novel inhibitor of CXCL10 expression from Ganoderma applanatum
2011
CXCL10 (inducible protein-10) is a highly inducible chemoattractant, which contributes to the recruitment of inflammatory cells, such as macrophages and T-lymphocytes, and thereby has important roles in chronic inflammatory conditions. In a search for new inhibitors of CXCL10 expression in MonoMac6 cells, a novel compound, designated as Ganodermycin, was isolated from fermentations of the basidiomycete Ganoderma applanatum. The structure was determined by a combination of spectroscopic techniques. Ganodermycin inhibited the lipopolysaccharide (LPS)/interferon (IFN)-γ-induced CXCL10 promoter activity in transiently transfected MonoMac6 cells in a dose-dependent manner with IC(50) values of 1…
A bargaining model of Farrell inefficiency
1998
Abstract An enormous number of empirical papers have estimated technical efficiency, the distance of firms inside a frontier, following the model of Farrell (Farrell, 1957. The measurement of productive efficiency. Journal of the Royal Statistical Society Series A 120 (3), 253–290). We propose a theory that explains the distance these empirical papers seek to measure. The theory is based on the idea that workers can bargain low `effort' (high crew sizes etc.) if they and the firm have some monopoly power. We provide simple theoretical expressions for the empirical measures of technical and allocative efficiency and compare them to those in the statistical literature. We also consider the re…
Singular quasisymmetric mappings in dimensions two and greater
2018
For all $n \geq 2$, we construct a metric space $(X,d)$ and a quasisymmetric mapping $f\colon [0,1]^n \rightarrow X$ with the property that $f^{-1}$ is not absolutely continuous with respect to the Hausdorff $n$-measure on $X$. That is, there exists a Borel set $E \subset [0,1]^n$ with Lebesgue measure $|E|>0$ such that $f(E)$ has Hausdorff $n$-measure zero. The construction may be carried out so that $X$ has finite Hausdorff $n$-measure and $|E|$ is arbitrarily close to 1, or so that $|E| = 1$. This gives a negative answer to a question of Heinonen and Semmes.