Search results for "L1"
showing 10 items of 831 documents
Ustekinumab therapy changes the transcriptional activity pattern of TGF-β1–3 genes
2019
Introduction One of the examples of genes whose expression can be altered by the action of ustekinumab is TGF-β. It is a pleiotropic cytokine whose activity affects psoriatic changes and the state of homeostasis of the whole organism. Aim To evaluate the effect of ustekinumab on the transcriptional activity of TGF-b family genes in patients with psoriatic arthritis and to check whether the results obtained can be helpful in monitoring the progress of treatment. Material and methods From total PBMCs obtained from peripheral blood of 14 patients with psoriatic arthritis, total RNA was isolated. The expression level of the TGF-β1, TGF-β2 and TGF-β3 genes was determined by RT-qPCR in real time.…
Snail fauna of the oldest cemeteries from Riga (Latvia)
2008
We report on the snail fauna from one of the oldest cemeteries from Riga city (Latvia), viz. Lielie kapi and Pokrova kapi. A list of all the snail species recorded from both cemeteries and limited information on the biotope conditions are given. Cecilioides acicula (O.F. Müller, 1774) is first recorded from Latvia and was found at a grassland within the tomb area of the Pokrova kapi cemetery.
Addendum to the type catalogue of the malacological collection in the Museu de Ciències Naturals de Barcelona
2018
Noves aportacions al catàleg d’exemplars tipus de la col·lecció malacològica del Museu de Ciències Naturals de Barcelona S’amplia el catàleg d’exemplars tipus de mol·luscs del Museu de Ciències Naturals de Barcelona, publicat l’any 2008, amb nou material corresponent a 42 tàxons de mol·luscs continentals de la península Ibèrica, les illes Balears i les Canàries. La majoria d’espècimens pertanyen a les col·leccions històriques del Museu o a la col·lecció malacològica de Miquel Bech, donada a la institució el 2009. Per a cada tàxon representat s’aporta, entre d’altres dades, informació relativa a la categoria del tipus, el nombre d’exemplars, la procedència geogràfica, els espècimens tipus c…
Primera cita de Culex interrogator (Diptera: Culicidae) para la Hispaniola y actualización del listado de mosquitos de Jarabacoa, República Dominicana
2020
Desde que dio inicio el nuevo siglo, varios estudios sobre la culicidofauna de la Hispaniola han elevado el conocimiento de este grupo de artrópodos, muy relevantes desde el punto de vista médico y veterinario. En relación a la diversidad de la familia Culicidae, los hallazgos más recientes se han realizado en el municipio de Jarabacoa, República Dominicana. Con el objetivo de profundizar en la diversidad de los culícidos presentes en esta localidad montañosa de El Cibao, se procedió a la búsqueda de criaderos de mosquitos, sobre todo de origen natural, desde enero de 2018 hasta junio de 2019. La identificación de los especímenes se realizó mediante la utilización de lupa binocular y micros…
miR-7 Restores Phenotypes in Myotonic Dystrophy Muscle Cells by Repressing Hyperactivated Autophagy
2019
International audience; Unstable CTG expansions in the 3' UTR of the DMPK gene are responsible for myotonic dystrophy type 1 (DM1) condition. Muscle dysfunction is one of the main contributors to DM1 mortality and morbidity. Pathways by which mutant DMPK trigger muscle defects, however, are not fully understood. We previously reported that miR-7 was downregulated in a DM1 Drosophila model and in biopsies from patients. Here, using DM1 and normal muscle cells, we investigated whether miR-7 contributes to the muscle phenotype by studying the consequences of replenishing or blocking miR-7, respectively. Restoration of miR-7 with agomiR-7 was sufficient to rescue DM1 myoblast fusion defects and…
Association of interleukin-10G microsatellite polymorphism with the susceptibility of ankylosing spondylitis
2013
Study suggests an association of IL10.G poly- morphisms with AS which might contribute to the increased or decreased susceptibility to AS. IL10.G8 and G7 microsatellites alleles appear as protective alleles against the development of AS in the German subjects investigated here. Allele IL10.G9 seems to be a risk factor for the development of AS. This protective effect of variant promoter alleles could be related to differences in IL- 10 production, which may be clinically relevant.
Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease
2011
14 páginas, 8 figuras, 1 tabla.-- et al.
Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model
2012
SummaryMyotonic dystrophy type 1 (DM1) is a genetic disease caused by the pathological expansion of a CTG trinucleotide repeat in the 3' UTR of the DMPK gene. In the DMPK transcripts, the CUG expansions sequester RNA-binding proteins into nuclear foci, including transcription factors and alternative splicing regulators such as MBNL1. MBNL1 sequestration has been associated with key features of DM1. However, the basis behind a number of molecular and histological alterations in DM1 remain unclear. To help identify new pathogenic components of the disease, we carried out a genetic screen using a Drosophila model of DM1 that expresses 480 interrupted CTG repeats, i(CTG)480, and a collection of…
Molecular Effects of the CTG Repeats in Mutant Dystrophia Myotonica Protein Kinase Gene
2008
Myotonic Dystrophy type 1 (DM1) is a multi-system disorder characterized by muscle wasting, myotonia, cardiac conduction defects, cataracts, and neuropsychological dysfunction. DM1 is caused by expansion of a CTG repeat in the 3 untranslated region (UTR) of the Dystrophia Myotonica Protein Kinase (DMPK) gene. A body of work demonstrates that DMPK mRNAs containing abnormally expanded CUG repeats are toxic to several cell types. A core mechanism underlying symptoms of DM1 is that mutant DMPK RNA interferes with the developmentally regulated alternative splicing of defined pre-mRNAs. Expanded CUG repeats fold into ds(CUG) hairpins that sequester nuclear proteins including human Muscleblind-lik…
Poznawczo-behawioralne programy terapeutyczne wykorzystywane w pracy z wymagającymi wsparcia adolescentami z zaburzeniami ze spektrum autyzmu (ASD L1…
2020
Artykuł zawiera opis wybranych metod poznawczo-behawioralnych wykorzystywanych w pracy z wymagającą wsparcia młodzieżą z zaburzeniami ze spektrum autyzmu (ASD L1). We wstępie opisano pokrótce historię zaburzenia i podstawowe problemy występujące u dzieci i młodzieży ze spektrum zaburzeń autystycznych. W dalszej części przytoczono informacje na temat technik poznawczo-behawioralnych często stosowanych w pracy z tymi adolescentami. Omówiono przykładowe programy treningów umiejętności społecznych: PEERS (Program for the Education and Enrichment of Relationship Skills) oraz MASSI (Multimodal Anxiety and Social Skills Intervention). Przybliżono dwa programy wykorzystywane w pracy nad rozwijaniem…