Search results for "L26"
showing 10 items of 12 documents
Analysis of the determinants of entrepreneurial intention: the case of Burkina Faso
2018
International audience; In this study, we propose to analyze students' entrepreneurial intention, drawing on Lazear's (2004) self-selection model. This model captures the role of "human capital" in employment assignment and emphasizes the importance of the variety of skills in the individual's entrepreneurial orientation. For this purpose, we have a database collected in 2017 from over 1000 students at Ouaga I and Ouaga II universities in Burkina Faso. The results of estimates obtained using the quantile regression method show a positive and significant effect of the diversity of skills on the intention score, mainly at the median level. Even if the effect is not strong, this result support…
Institutional factors affecting entrepreneurship: A QCA analysis
2022
A country's institutional framework plays a crucial role in promoting entrepreneurship, which drives economic growth. Encouraging a minimum level of certainty in ambiguous environments characterized by risk taking is important. Aware of this importance, we analyze the influence of institutional factors on entrepreneurship development. Specifically, we analyze political stability, government effectiveness, regulatory quality, a robust rule of law, the ease of starting a new business, and the ease of obtaining credit. We develop two models to explain the presence and absence of entrepreneurship. To do so, we apply qualitative comparative analysis (QCA) to a sample of 48 countries using data s…
An international cohort comparison of size effects on job growth
2015
The contribution of different-sized businesses to job creation continues to attract policymakers’ attention, however, it has recently been recognized that conclusions about size were confounded with the effect of age. We probe the role of size, controlling for age, by comparing the cohorts of firms born in 1998 over their first decade of life, using variation across half a dozen northern European countries Austria, Finland, Germany, Norway, Sweden, and the UK to pin down size effects. We find that a very small proportion of the smallest firms play a crucial role in accounting for cross-country differences in job growth. A closer analysis reveals that the initial size distribution and surviv…
Entrepreneurship – Some General Knowledge
2013
The aim of this article is to provide some general information about entrepreneurship and some insights on the early theories about it. A brief overview of the main entrepreneurship measurement programme will provide some facts about the evolution of the entrepreneurial activity in Romania in the last few years.
The role of intellectual capital and entrepreneurial characteristics as innovation drivers
2014
La innovacion y la iniciativa empresarial son estrategias organizacionales esenciales para encontrar una salida a la crisis mundial que afecta a las empresas de hoy en dia. Por lo tanto, el estudio de como los factores organizacionales como el capital intelectual o las caracteristicas de los empresarios afectan el exito de un proyecto empresarial innovador, es de gran importancia para ayudar a las organizaciones actuales a encontrar una solucion a este problema. El capital intelectual implica una inversion en capital humano, estructural y relacional. Por consiguiente, nuestro objetivo investigativo se centra en analizar la influencia del capital intelectual asi como las caracteristicas pers…
One swallow does not make a summer: episodes and persistence in high growth
2021
This paper analyzes firms’ episodes (spells) of high growth (HG) using a sample of Spanish manufacturing firms observed over two decades. The use of duration models allows us to investigate the following: (i) the probability of experiencing HG episodes, (ii) persistence in HG, and (iii) the determinants of the transitions in and out of the HG state and whether their impact varies over the business cycle. We find that about half of the firms experience at least one HG episode, but they seldom experience more than one. Moreover, high-growth status is rarely repeated due to high first-year selection. Yet, in subsequent years beyond the first one, the hazard rate from HG status falls substantia…
Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models.
2018
Immune checkpoint blockade (ICB) is currently evaluated in patients with glioblastoma (GBM), based on encouraging clinical data in other cancers, and results from studies with the methylcholanthrene-induced GL261 mouse glioma. In this paper, we describe a novel model faithfully recapitulating some key human GBM characteristics, including low mutational load, a factor reported as a prognostic indicator of ICB response. Consistent with this observation, SB28 is completely resistant to ICB, contrasting with treatment sensitivity of the more highly mutated GL261. Moreover, SB28 shows features of a poorly immunogenic tumor, with low MHC-I expression and modest CD8(+) T-cell infiltration, suggest…
Angiotensin II-Induced Mononuclear Leukocyte Interactions with Arteriolar and Venular Endothelium Are Mediated by the Release of Different CC Chemoki…
2006
Abstract Angiotensin II (Ang-II) is associated with atherogenesis and arterial subendothelial mononuclear leukocyte infiltration. We have demonstrated that Ang-II causes the initial attachment of mononuclear cells to the arteriolar endothelium. We now report on the contribution of CC chemokines to this response. Intraperitoneal administration of 1 nM Ang-II induced MCP-1, RANTES, and MIP-1α generation, maximal at 4 h, followed by mononuclear leukocyte recruitment at 8 and 24 h. Using intravital microscopy within the rat mesenteric microcirculation 4 h after exposure to 1 nM Ang-II, arteriolar mononuclear cell adhesion was 80–90% inhibited by pretreatment with Met-RANTES, a CCR1 and CCR5 ant…
MYD88 L265P mutation and interleukin‐10 detection in cerebrospinal fluid are highly specific discriminating markers in patients with primary central …
2021
Reliable biomarkers are needed to avoid diagnostic delay and its devastating effects in patients with primary central nervous system (CNS) lymphoma (PCNSL). We analysed the discriminating sensitivity and specificity of myeloid differentiation primary response (88) (MYD88) L265P mutation (mut-MYD88) and interleukin-10 (IL-10) in cerebrospinal fluid (CSF) of both patients with newly diagnosed (n = 36) and relapsed (n = 27) PCNSL and 162 controls (118 CNS disorders and 44 extra-CNS lymphomas). The concordance of MYD88 mutational status between tumour tissue and CSF sample and the source of ILs in PCNSL tissues were also investigated. Mut-MYD88 was assessed by TaqMan-based polymerase chain reac…
Los emprendedores surgidos de las empresas multinacionales de inversión extranjera directa: un estudio exploratorio en Costa Rica
2014
ResumenEl presente trabajo busca evaluar la creación de empresas por parte de exempleados de empresas multinacionales de inversión extranjera directa. En concreto, se busca dimensionar el fenómeno, caracterizarlo, así como valorar el desempeño de las empresas creadas. El estudio se hizo mediante un muestreo aleatorio simple con margen de error del 7% y nivel de confianza del 95%, sobre una base de datos de 11.120 exempleados de empresas multinacionales en Costa Rica (n=175). Además se utilizó un grupo control ad hoc. Los resultados muestran cómo son estos emprendedores, el proceso creador experimentado, las características y el desempeño de las nuevas empresas.AbstractThe aim of this invest…