Search results for "LAB"
showing 10 items of 7932 documents
Les néoplasies plasmocytaires et autres dysglobulinémies en population générale
2019
Resume Les neoplasies plasmocytaires occupent en 2012 en France le premier rang des hemopathies malignes en nombre. Majo-ritairement il s’agit de myelome multiple ou de plasmocytome (MM/P) mais on retrouve aussi des pathologies de severite variable. La classification OMS actuelle definit les gammapathies monoclonales de signification indeterminee en une entite a part entiere. Des progres importants dans la prise en charge de ces pathologies ont ete realises grâce a une meilleure connaissance de la maladie et a l’utilisation de nouvelles molecules therapeutiques. Ces progres peuvent etre visualises par l’etude des tendances d’indicateurs epidemiologiques en population generale. Les donnees f…
Deduplication Potential of HPC Applications’ Checkpoints
2016
HPC systems contain an increasing number of components, decreasing the mean time between failures. Checkpoint mechanisms help to overcome such failures for long-running applications. A viable solution to remove the resulting pressure from the I/O backends is to deduplicate the checkpoints. However, there is little knowledge about the potential to save I/Os for HPC applications by using deduplication within the checkpointing process. In this paper, we perform a broad study about the deduplication behavior of HPC application checkpointing and its impact on system design.
Cancers du côlon : prise en charge moléculaire
2018
Resume Le demembrement moleculaire des cancers et en particulier des cancers colorectaux conduit a des prises en charge de plus en plus adaptees et de plus en plus complexes. Ce demembrement a abouti a de nombreuses classifications et finalement a une classification moleculaire consensuelle en 2015. Cette classification consensuelle reste pour l’instant non utilisable au quotidien. Plusieurs facteurs moleculaires (statut MSS/MSI, statut BRAF, statut RAS) sont desormais indispensables a la prise en charge du cancer colorectal que ce soit en situation adjuvante ou metastatique. D’autres facteurs tels que le statut HER2 et l’expression de mir-31-3p sont regulierement pris en compte au cas par …
Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Amoxicillin Trihydrate
2018
Literature and experimental data relevant to waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release solid oral dosage forms containing amoxicillin trihydrate are reviewed. Solubility and permeability characteristics according to the Biopharmaceutics Classification System (BCS), therapeutic uses, therapeutic index, excipient interactions, as well as dissolution and BE and bioavailability studies were taken into consideration. Solubility and permeability studies indicate that amoxicillin doses up to 875 mg belong to BCS class I, whereas 1000 mg belongs to BCS class II and doses of more than 1000 mg belong to BCS class IV. Considering all aspects, the biowaiver pro…
In vitro bioavailability of iron and calcium in cereals and derivatives: A review
2016
Cereals are a staple food in both developed and developing countries, and are considered to be the best vehicle for iron and calcium fortification, as an important strategy for combating dietary deficits. Inadequate dietary intake of iron and calcium is related to a number of disease conditions such as anemia, osteoporosis, hypertension, and different cancers. From a nutritional point of view, it is interesting to know not only the amount of minerals consumed, but also their bioavailability. The present study reviews the current knowledge on the in vitro bioavailability of iron and calcium in cereals, placing emphasis on the methodologies used and on the influence of dietary factors and foo…
Human skeletal muscle type 1 fibre distribution and response of stress-sensing proteins along the titin molecule after submaximal exhaustive exercise.
2017
Early responses of stress-sensing proteins, muscle LIM protein (MLP), ankyrin repeat proteins (Ankrd1/CARP and Ankrd2/Arpp) and muscle-specific RING finger proteins (MuRF1 and MuRF2), along the titin molecule were investigated in the present experiment after submaximal exhaustive exercise. Ten healthy men performed continuous drop jumping unilaterally on a sledge apparatus with a submaximal height until complete exhaustion. Five stress-sensing proteins were analysed by mRNA measurements from biopsies obtained immediately and 3 h after the exercise from exercised vastus lateralis muscle while control biopsies were obtained from non-exercised legs before the exercise. Decreased maximal jump h…
Genome-Wide Estimation of the Spontaneous Mutation Rate of Human Adenovirus 5 by High-Fidelity Deep Sequencing
2016
Rates of spontaneous mutation determine the ability of viruses to evolve, infect new hosts, evade immunity and undergo drug resistance. Contrarily to RNA viruses, few mutation rate estimates have been obtained for DNA viruses, because their high replication fidelity implies that new mutations typically fall below the detection limits of Sanger and standard next-generation sequencing. Here, we have used a recently developed high-fidelity deep sequencing technique (Duplex Sequencing) to score spontaneous mutations in human adenovirus 5 under conditions of minimal selection. Based on >200 single-base spontaneous mutations detected throughout the entire viral genome, we infer an average mutatio…
Health gains through loss frames: Testing the effectiveness of message framing on citizens' use of nutritional warnings.
2021
Abstract The aim of the present work was twofold: (i) to evaluate the effect of nutritional warnings and health-related packaging cues (nutrient claim and images of natural foods) on consumers' food choices, and (ii) to evaluate the influence of two types of messages (gain-framed and loss-framed) aimed at encouraging the use of such warnings and packaging cues on food choices. A total of 510 participants were recruited using an advertisement on Facebook and Instagram targeted at Uruguayan adult users. Participants were randomly allocated to one of three experimental groups: control (n = 167), loss-framed messages (n = 177) and gain-framed messages (n = 166). Then, they completed a choice-co…
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error
2018
Skin affections after sulfur mustard (SM) exposure include erythema, blister formation and severe inflammation. An antidote or specific therapy does not exist. Anti-inflammatory compounds as well as substances counteracting SM-induced cell death are under investigation. In this study, we investigated the benzylisoquinoline alkaloide berberine (BER), a metabolite in plants like berberis vulgaris, which is used as herbal pharmaceutical in Asian countries, against SM toxicity using a well-established in vitro approach. Keratinocyte (HaCaT) mono-cultures (MoC) or HaCaT/THP-1 co-cultures (CoC) were challenged with 100, 200 or 300 mM SM for 1 h. Post-exposure, both MoC and CoC were treated with 1…
The Amount of Melanin Influences p16 Loss in Spitzoid Melanocytic Lesions: Correlation With CDKN2A Status by FISH and MLPA.
2019
AIMS The risk assessment of spitzoid lesions is one of the most difficult challenges in dermatopathology practice. In this regard, the loss of p16 expression and the homozygous deletion of CDKN2A, have been pointed in the literature as reliable indicators of high risk. However, these findings are poorly reproducible, and the molecular bases underlying the loss of p16 expression remain unclear. We aimed to identify the underlying events causing loss of CDKN2A/p16 in spitzoid tumors. MATERIALS AND METHODS We evaluated the immunohistochemical expression of p16, and the presence of CDKN2A genetic alterations detected through fluorescence in situ hybridization (FISH) and multiplex ligation-depen…