Search results for "LDH"
showing 10 items of 1015 documents
Inflammatory Cytokine IFNγ, IL-6, and IL-10 Association with Childhood Obesity
2021
Abstract Childhood obesity carries a high risk of serious life-threatening cardiometabolic diseases in adulthood, which are associated with low-grade inflammation. The aim of the present study was to measure serum cytokine concentrations in obese children recruited during endocrinology consultations and compared to lean control the results. Blood serum concentrations of interferon gamma (IFNγ), IL-1β, Interleukin 6 IL-6, IL-10, and TNF-α were analysed applying Luminex xMap technology with Millipore reagent kits. Statistical analyses were performed using t-test comparisons and Spearman correlations. Obese children had highly significant increased levels of circulating IFNγ (p < 0.0001), I…
Children as social actors negotiating their privacy in the digital commercial context
2023
This study advances research on children’s negotiation of online commercial privacy by identifying an act of digital agency by children that may serve their current needs but can also impact children negatively. Secondly, it identifies certain factors children consider while evaluating the trustworthiness of apps and websites before disclosing information online. Eight focus group discussions with children (13–16 years) in Finland’s capital region are analysed using thematic analysis. Our findings highlight that while children’s digital literacy education is needed, ensuring that education translates to children’s online practices is also essential. We also recommend increasing corporations…
Maternal Ferritin Levels during Pregnancy and ADHD Symptoms in 4-Year-Old Children: Results from the INMA–INfancia y Medio Ambiente (Environment and …
2020
Ferritin status during prenatal brain development may influence the risk of attention deficit and hyperactivity disorder (ADHD) symptoms in childhood. We investigated the association of maternal ferritin in pregnancy and ADHD-like symptoms in offspring. A total of 1095 mother-child pairs from three birth cohorts of the INMA Project (Spain) were studied. Maternal plasma ferritin in pregnancy was measured at 11.57 weeks of gestation. Children&prime
Protein Conformational Landscapes and Catalysis. Influence of Active Site Conformations in the Reaction Catalyzed by L-Lactate Dehydrogenase
2015
In the past decade, L-Lactate Dehydrogenase (LDH) has become an extremely useful marker in both clinical diagnosis and in monitoring the course of many human diseases. It has been assumed since the 1980s that the full catalytic process of LDH starts with the binding of the cofactor and the substrate followed by the enclosure of the active site by a mobile loop of the protein before the reaction takes place. In this paper, we show that the chemical step of the LDH-catalyzed reaction can proceed within the open loop conformation, and the different reactivity of the different protein conformations would be in agreement with the broad range of rate constants measured in single-molecule spectrom…
Lisää taitoja ja mahdollisuuksia varhaiskasvatukseen: Tavoitteena tasa-arvoisempi ja kielitietoisempi varhaiskasvatus
2021
Kasvatuksellisen ja koulutuksellisen tasa-arvon toteutuminen monikielistyvässä Suomessa edellyttää entistä kielitietoisempaa varhaiskasvatusta (Puukko ym., 2019). Monikulttuurisuuden kohtaaminen on arvioitu yhdeksi keskeisimmäksi varhaiskasvatuksen tulevaisuuden osaamistaidoksi (Karila ym., 2013), ja monikielisyyden lisääntyminen haastaa ja kannustaa kehittämään entistä sensitiivisempiä, vuorovaikutuksellisia pedagogisia käytänteitä (Karila, 2016). Teimme keväällä 2017 verkkokyselyn, jonka tavoitteena oli kerätä tietoa ja näkökulmia monikielisyyden kohtaamisesta sekä kielitietoisista työskentelytavoista suomalaisessa varhaiskasvatuksessa. Kysely oli suunnattu monikielisessä lapsiryhmässä ty…
Physical play - How do we inspire and motivate young children to be physically active through play? An international analysis of twelve countries’ na…
2023
Lifelong movement and physical activity (PA) patterns develop during early childhood. Therefore, educators (teachers and practitioners) in early childhood education and care (ECEC) should provide opportunities to support children’s play, PA, and movement development. The World Health Organization (2019) offers new recommendations for PA, for children under five years. The guidelines do not specify the ways ECEC staff can support PA through play. Therefore, this paper investigates, how physical play (PP) is enacted globally. An international policy and practice analysis of twelve countries, (Australia [Victoria], Belgium [Flanders], Canada [Alberta], China, Finland, Ireland, Italy, Portugal,…
A glimpse into the socialization of bilingual youngsters as interpreters: the case of Latino bilinguals brokering communication for their families an…
2010
Work on bilinguals who act as family interpreters, while not focused particularly on the development of translation and interpreting abilities, contributes to our understanding of life experiences of the individuals who begin to interpret early in their lives (Valdés and Angelelli 2003). With some exceptions (Harris 1977, 1978, 1980, 1992; Toury 1984, 1995) very little has been written about the lived experiences of young interpreters and/or about their socialization as family interpreters. Since most of the community interpreters of today were interpreters in their late childhood and adolescence, getting a glimpse into their lives and experiences may help researchers (and teachers of inter…
Melatonin Levels in Children with Obesity Are Associated with Metabolic Risk and Inflammatory Parameters
2021
Melatonin, the hormone of circadian rhythm regulation, is involved in the modulation of mitochondrial activity through its antioxidant and anti-inflammatory properties. Alteration of circadian rhythms such as sleep is related to obesity and metabolic pathogenesis in adulthood, but studies during childhood are scarce. The present study investigated the association of melatonin with metabolic and inflammatory markers in children with (n = 113) and without obesity (n = 117). Melatonin was measured in saliva four and two hours before bedtime, and after one hour of sleep. Cardiometabolic factors, high sensitivity C-reactive protein, immune markers (monocyte chemoattractant protein-1, plasminogen…
De l’effet transformatif de l’imaginaire :
2019
The polymorphic concept of the novel and the intertextuality of the literary genres characterize the work of Georges Perec, whose writing looks into different genres, codes and models and combines them in order to preserve the singularity of each of his works. Among these W ou le souvenir d’enfance, an unclassifiable novel that alternates fiction and childhood memories, has been the result of a very difficult writing process, that genetic documents can only partly clear up. We propose to reflect on the process of re-functionalization of the adventure novel W, which appeared before as a serialized text in the journal La Quinzaine littéraire and was then integrated into the great autobiograph…
Two languages in the air : a cross-cultural comparison of preschool teachers’ reflections on their flexible bilingual practices
2016
Bilingual preschool education is under researched compared with bilingual school education. There is also a lack of research on bilingual preschool teachers’ agency and how they negotiate between two languages in the classroom. We examined the language practices of five bilingual preschool teachers working within three different socio-linguistic settings, in Finland (Finnish–Swedish and Russian–Finnish contexts) and Israel (an Arabic–Hebrew context) and interviewed the teachers about their use of languages in the classroom. We found that in each context the teachers reported modifications to an initial bilingual education model over time: from a strict separation of languages, to flexible b…