Search results for "LDL"

An International Atherosclerosis Society Position Paper: global recommendations for the management of dyslipidemia.

2014

An international panel of the International Atherosclerosis Society has developed a new set of recommendations for management of dyslipidemia. The panel identifies non-high density lipoprotein cholesterol (non-HDL-C) as the major atherogenic lipoprotein. Primary and secondary prevention are considered separately. Optimal levels for atherogenic lipoproteins are derived for the two forms of prevention. For primary prevention, the recommendations emphasize lifestyle therapies to reduce atherogenic lipoproteins; drug therapy is reserved for higher risk subjects. Risk assessment is based on estimation of lifetime risk according to differences in baseline population risk in different nations or r…

IMPROVEMENT IN REDOX HOMEOSTASIS AFTER CYTOREDUCTIVE SURGERY IN COLORECTAL ADENOCARCINOMA

2021

Colorectal cancer (CRC) as one the most common cancer type is associated with oxidative stress. Surgery is the only curative modality for early-stage CRC. The aim of this study was to evaluate the oxidative damage biomarkers as well as enzymatic and nonenzymatic antioxidants in patients with CRC before and after tumor resection and in healthy controls. 60 patients with stage I/II colorectal adenocarcinoma and 43 healthy controls were recruited in this study. We measured plasma levels of oxidative damage biomarkers, including advanced oxidation protein products (AOPP), advanced glycation end products (AGEs), malondialdehyde (MDA), and oxidized low-density lipoprotein (ox-LDL) at baseline and…

Dietary Supplements as Surrogate of Mediterranean Diet in Healthy Smoking Subjects

2017

The interventions to slow aging, favoring active life expectancy, represent the new perspectives in ageing investigation. Some mechanisms that delay or prevent the onset of aging pathologies have been identified. Between them, a healthy lifestyle seems to reduce many risk factors. In particular, eating habits represent the most concrete, low-cost way to act on aging process. Mediterranean diet has received much attention since its antioxidant and anti-inflammatory effects have been consistently demonstrated. Unfortunately, many people follow a Western diet, poor in phytochemicals that represent the main source of beneficial effects of this dietary pattern. So, supplements administration sho…

Modulation of lipid metabolism and colonic microbial diversity of high-fat-diet C57BL/6 mice by inulin with different chain lengths

2019

Abstract The physicochemical properties, biological functions and microbial degradation of inulins differ according to their degree of polymerization. However, the relationship between inulin activities and its effect on gut microbiota remains unknown. In this study, high fat diet with inulin (1 or 5 g/kg·bw), either with short or long chains groups were administered to different groups of mice (n = 10) for 10 weeks in order to investigate the effect of inulin on the microbial diversity of the animals. Litchi pericarp procyanidins (LPPC) were used for comparison purposes. Furthermore, the lipid metabolism and key regulator genes in mice were determined. The results indicated that natural in…

Female Preference and Adverse Developmental Effects of Glyphosate-Based Herbicides on Ecologically Relevant Traits in Japanese Quails

2019

Controversial glyphosate-based herbicides (GBHs) are the most frequently used herbicides globally. An increasing number of studies have identified GBH residues in soil, water, and even human food that may expose nontarget organisms including wildlife, livestock, and humans to health risks. After a heated debate, the European Union allowed the use of GBHs to continue until 2022, after which their risks will be re-evaluated. Thus, decision makers urgently need scientific evidence on GBH residues and their possible effects on ecosystems. An important, yet neglected, aspect is to assess whether animals show preference or avoidance for GBH-contaminated food, as it can influence the likelihood of…

LRP1 modulates APP trafficking along early compartments of the secretory pathway

2008

The amyloid beta peptide (A beta) is a central player in Alzheimer's disease (AD) pathology. A beta liberation depends on APP cleavage by beta- and gamma-secretases. The low density lipoprotein receptor related protein 1 (LRP1) was shown to mediate APP processing at multiple steps. Newly synthesized LRP1 can interact with APP, implying an interaction between these two proteins early in the secretory pathway. We wanted to investigate whether LRP1 mediates APP trafficking along the secretory pathway, and, if so, whether it affects APP processing. Indeed, the early trafficking of APP within the secretory pathway is strongly influenced by its interaction with the C-terminal domain of LRP1. The …

Effetti della cattività  su alcuni parametri ematologici del grifone (Gyps fulvus)

2017

Haematological analysis is an essential field of veterinary medicine that provides inexpensive and reliable support to determinate animal health. The knowledge of how different factors affect the normal mean values of blood parameters is key to understand and improve animal health. In order to investigate how captivity can affect the haematological profile of birds of prey, the erythrocyte count, haemoglobin concentration, haematocrit, mean corpuscular volume, total leukocytes count of 123 griffon vultures (Gyps fulvus) were analysed. The birds were divided into 4 groups according to their life conditions: a control group of free-living griffons, 2 semi-captive groups held in an aviary for …

Objetivos terapéuticos del colesterol LDL y cambios de la proteína C reactiva en pacientes de alto riesgo coronario

2009

Resumen Fundamentos y objetivo Valorar los efectos de la asociacion de ezetimiba y estatina (terapia combinada), respecto a duplicar la dosis de estatina, a la hora de alcanzar los objetivos terapeuticos de colesterol ligado a las lipoproteinas de baja densidad (c-LDL) y en la variacion de la proteina C reactiva (PCR). Pacientes y metodos Estudio longitudinal retrospectivo de pacientes con dislipemia en tratamiento con estatina y control lipidico insuficiente. Se incluyeron 111 pacientes; a 59 se les duplico la dosis de estatina previa y a 52 se les anadio ezetimiba a la estatina (terapia combinada). Se calcularon las diferencias en lipidos y la proteina C reactiva. Resultados La terapia co…

Bassa prevalenza delle LDL aterogene piccole e dense in una popolazione mediterranea

2002

Lipid profile during pregnancy in HIV-infected women

2006

Purpose: We investigated the evolution of serum lipid levels in HIV-infected pregnant women and the potential effect of antiretroviral treatment during pregnancy using data from a national surveillance study. Method: Fasting lipid measurements collected during routine care in pregnancy were used, analyzing longitudinal changes and differences in lipid values at each trimester by protease inhibitors (Pls) and stavudine use. Multivariate analyses were used to control for simultaneous factors potentially leading to hyperlipidemia. Study population included 248 women. Results: Lipid values increased progressively and significantly during pregnancy: mean increases between the first and third tri…