Search results for "LED"

showing 10 items of 8768 documents

Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal

2016

AbstractThe ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter taste receptor gene. It has long been hypothesized that global genetic diversity at this locus evolved under pervasive pressures from balancing natural selection. However, recent high-resolution population genetic studies of TAS2Rs suggest that demographic events have played a critical role in the evolution of these genes. We here utilized the largest TAS2R38 database yet analyzed, consisting of 5,589 individuals from 105 populations, to examine natural selection, haplotype frequencies and linkage disequilibrium to estimate the effects of both selectio…

AFRICASELECTION0301 basic medicineLinkage disequilibriumPopulationLocus (genetics)Taste Genetics Evolutionary geneticsBiologyBalancing selectionLinkage DisequilibriumArticleReceptors G-Protein-CoupledEvolution Molecular03 medical and health sciences0302 clinical medicineDatabases GeneticGenetic variationLOCUSHumansPHENYLTHIOCARBAMIDESelection GeneticeducationPOPULATIONVEGETABLESGeneticsGenetic diversityeducation.field_of_studyHUMAN GENETIC DIVERSITY; SENSITIVITY; POPULATION; AFRICA; PTC; PHENYLTHIOCARBAMIDE; VEGETABLES; SELECTION; HUMANS; LOCUSNatural selectionMultidisciplinaryGenetic Variationphenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP)- TAS2R38 haplotypes-natural selectionPhenylthioureaCorrigendaSettore BIO/18 - GeneticaPTC030104 developmental biologyTAS2R38HaplotypesPropylthiouracilTasteHUMAN GENETIC DIVERSITYSENSITIVITY030217 neurology & neurosurgery
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Importance of proper conduct of clinical trials

2021

AFRICAclinical trialsModels StatisticalActuarial sciencebusiness.industryMEDICINEinferential statisticsEvidence-based medicinerandomised controlled trialsBayesian statisticsBayesian statisticBayesian statisticsClinical trialAnesthesiology and Pain MedicineResearch DesignData Interpretation StatisticalCausal inferenceStatistical inferenceHumansMedicinecausal inferencebusinessevidence-based medicineRandomized Controlled Trials as Topic
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Stable isotopes covering 96-7 ka BP from stalagmite CM (Santo Tomas Cave, Cuba)

2020

We present a new speleothem trace element and stable isotope record, which extends previous paleoclimate evidence from Cuban speleothems to the last 96 ka. Stable isotope samples were micromilled at a resolution of 0.10-0.33mm, and measured using an IRMS equipped with a Gasbench. Line scans of Element/Calcium ratios of the speleothem were measured by laser ablation ICPMS and were reduced to the resolution of the stable isotope records.

AGESpeleothem sampleδ13C stackedδ13CEarth System Researchpaleoclimatologyδ18O stackedstackedCentral Americaδ18OMass spectrometer DeltaPlusXL coupled to a Gasbench IIspeleothemStable isotopes
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Do ventilatory parameters influence outcome in patients with severe acute respiratory infection? Secondary analysis of an international, multicentre1…

2021

Purpose: To investigate the possible association between ventilatory settings on the first day of invasive mechanical ventilation (IMV) and mortality in patients admitted to the intensive care unit (ICU) with severe acute respiratory infection (SARI). Materials and methods: In this pre-planned sub-study of a prospective, multicentre observational study, 441 patients with SARI who received controlled IMV during the ICU stay were included in the analysis. Results: ICU and hospital mortality rates were 23.1 and 28.1%, respectively. In multivariable analysis, tidal volume and respiratory rate on the first day of IMV were not associated with an increased risk of death; however, higher driving pr…

ARDSSoins intensifs réanimationmedicine.medical_treatmentAirway pressuresPEEP positive end-expiratory pressureCritical Care and Intensive Care Medicinelaw.inventionHypoxemiaCohort StudiesPositive-Pressure RespirationMechanical ventilationSARI severe acute respiratory infectionlawHospital MortalityProspective StudiesIQR interquartile rangesProspective cohort studyRCT randomized controlled trialTidal volumeSOFA Sequential Organ Failure AssessmentSAPS Simplified Acute Physiology ScoreIntensive care unitVCV volume-controlled ventilationHIV human immunodeficiency virusIntensive Care UnitsIC GLOSSARI Intensive Care Global Study on Severe Acute Respiratory Infectionmedicine.symptomCohort studyLOS length of staymedicine.medical_specialtyVt tidal volumeCOPD Chronic obstructive pulmonary diseaseNYHA New York Heart Association.PCV pressure-controlled ventilationArticleInternal medicineICU Intensive Care UnitSIMV Synchronized intermittent mandatory ventilationmedicineTidal VolumeHumansDP driving pressurePEEPARDS acute respiratory distress syndromeMechanical ventilationbusiness.industryOdds ratioPneumoniaPlateau pressuremedicine.diseaseRespiration ArtificialVILI ventilator induced lung injuryCI confidence intervalOR odds ratioIMV invasive mechanical ventilationCPAP continuous positive airway pressureARDSbusinessSD standard deviationECMO extracorporeal membrane oxygenationPBW predicted body weightPplat plateau pressure
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Nuclear anapole moment interaction in BaF from relativistic coupled-cluster theory

2018

We present high accuracy relativistic coupled cluster calculations of the P-odd interaction coefficient $W_A$ describing the nuclear anapole moment effect on the molecular electronic structure. The molecule under study, BaF, is considered a promising candidate for the measurement of the nuclear anapole moment, and the preparation for the experiment is now underway [Altunas et al., Phys. Rev. Lett. 120, 142501 (2018)]. Influence of various computational parameters (size of the basis set, treatment of relativistic effects, and treatment of electron correlation) on the calculated $W_A$ coefficient is investigated and a recommended value of 147.7 Hz with an estimated uncertainty of 1.5% is prop…

ATOMIC PARITY NONCONSERVATIONDIATOMIC-MOLECULESP-ODDVIOLATIONAtomic Physics (physics.atom-ph)Nuclear TheoryDENSITY FUNCTIONALSFOS: Physical sciences01 natural sciences010305 fluids & plasmasPhysics - Atomic PhysicsENHANCEMENTMolecular electronic structure0103 physical sciencesIMPLEMENTATIONNuclear Experiment010306 general physicsBasis setPhysicsElectronic correlationELECTRIC-FIELD GRADIENTSDiatomic moleculeWEAK-INTERACTIONSCoupled clusterMoment (physics)Atomic physicsRelativistic quantum chemistryAPPROXIMATIONPhysical Review A
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Asymptotic potentials and rate constants in the adiabatic capture centrifugal sudden approximation for X + OH(X-2 Pi) -> OX + H(S-2) reactions where …

2012

International audience; New long-range multipolar coefficients for the X + OH(X-2 Pi) interactions, where X = O(P-3), S(P-3) and N(S-4), are given here. They have been evaluated on the basis or monomer properties of the atoms and OH such as the dipole and quadrupole moments, and the static and dynamic polarizabilities. Each matrix element of the 18 x 18 (8 x 8 for N + OH) quasi-degenerate asymptotic potentials has been built up by means of the perturbation theory up to second order including or not the fine-structure of O, S and OH. The adiabatic potentials, obtained after diagonalization of the full matrix, show many crossings and complex behaviors near the asymptotes. Using the entrance c…

Ab initio010402 general chemistryKinetic energy7. Clean energy01 natural sciencesBiochemistryDIPOLE POLARIZABILITIESATOMSAb initio quantum chemistry methodsLOW-TEMPERATUREOH RADICALS0103 physical sciencesCOUPLED-CLUSTER CALCULATIONSPhysical and Theoretical ChemistryPerturbation theoryAdiabatic processKINETICS010304 chemical physicsChemistryRANGECondensed Matter PhysicsPotential energy0104 chemical sciencesQUADRUPOLE-MOMENTSO-2[SDU]Sciences of the Universe [physics]QuadrupoleCLAtomic physicsGround state
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Ricerche in tema di società questuarie

2019

Intorno al regime delle società di tipo questuario – riconducibili agli schemi teorici della societas universorum quae ex quaestu veniunt – e delle società unius alicuius negotiationis e unius rei, si profusero gli sforzi interpretativi dei giuristi romani, fin dalla fine dell’età repubblicana. La monografia scientifica ripercorre le tracce della individuazione della nozione stessa di quaestus (guadagno), con particolare riferimento alla inclusione al suo interno delle donazioni cd. remuneratorie; ancora, ricostruisce il dibattito giurisprudenziale sorto intorno alla questione se i soci – nella determinazione delle quote – dovessero rispettare una proporzione rispetto ai conferimenti, con u…

About the regulations of the societas quaestus - referable to the societas universorum quae ex quaestu veniunt and to the societas unius alicuius negotiationis and unius rei - the interpretative efforts of the Roman jurists were given profusely since the end of the republican age. The scientific monograph puts itself on the traces of identifying the notion of quaestus (gain) with particular reference to the inclusion within it of the so-called remuneration gifts. Furthermore it reconstructs the jurisprudential debate that aroses around the question of whether the socii - in the determination of the shares - had to respect a proportion with the contributions and in this sense with an attempt to explain the existing contrast between a passage from the Digest and one of the Iustiniani Institutiones. Moreover always with specific reference to the societas quaestus the monograph investigates the setting-up of the intempestiva renuntiatio supporting its origin out of the contrast between Proculiani and Sabiniani so far postulated in doctrine. Finally the book closes with a chapter dedicated to the genesis of the term egestas which appears in a fragment of Modestinus (D. 17.2.4.1) dedicated to the causes of dissolution of the societas consensu contractaSettore IUS/18 - Diritto Romano E Diritti Dell'Antichita'
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Quantitative analysis of the effect of controlled-release formulation on nonlinear gastrointestinal absorption of P-glycoprotein substrate talinolol …

2020

Abstract Oral absorption of talinolol, a substrate of P-glycoprotein (P-gp), from a sustained-release (SR) formulation was reportedly decreased compared to that from an immediate-release (IR) formulation. The aim of this study was to predict and understand the effect of controlled-release formulation on the oral absorption of P-gp substrates by developing a physiologically based pharmacokinetic (PBPK) absorption model incorporating multiple kinetic parameters obtained from in vitro studies, using talinolol as a model substrate. Simulation analysis using the developed PBPK absorption model indicated that the clinically observed marked decrease in the plasma concentration of talinolol adminis…

Absorption (pharmacology)Physiologically based pharmacokinetic modellingChromatographyPharmaceutical ScienceSubstrate (chemistry)02 engineering and technology021001 nanoscience & nanotechnology030226 pharmacology & pharmacyControlled releaseIntestinal absorption03 medical and health scienceschemistry.chemical_compound0302 clinical medicinechemistryPharmacokinetics0210 nano-technologyQuantitative analysis (chemistry)TalinololJournal of Drug Delivery Science and Technology
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The effects of water absorption and salt fog exposure on agglomerated cork compressive response

2022

The replacement of synthetic foams with agglomerated cork in sandwich composites can meet the increasing environmental concerns. Its peculiar morphology and chemical composition lead to outstanding dimensional recovery that endorsed a broad investigation of its compressive behavior. The knowledge of neat material response is fundamental to obtain a reliable design dataset, but it is necessary to consider all the environmental factors (water, moisture and sunlight) that significantly modify material mechanical properties. In view of this, the present work investigates the effect of distilled and seawater absorption and salt fog exposure on the compressive behavior of two agglomerated corks w…

Absorption of waterMaterials scienceAgglomerated corkMechanical propertiesCorkengineering.materialThermal diffusivitywater absorptionGeneral Materials ScienceComposite materialSandwich structuresChemical compositionSalt fog exposurePolymer compositesMaterialesMoistureForestryagglomerated corkagglomerated cork; water absorption; salt fog exposureCompressive strengthSettore ING-IND/22 - Scienza E Tecnologia Dei MaterialiDistilled waterengineeringsalt fog cork aging compressive responseWater absorptionSeawatersalt fog exposure
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Ab Initio Studies of Triplet-State Properties for Organic Semiconductor Molecules

2012

Triplet–triplet annihilation (TTA) leads to a reduced efficiency of organic light-emitting diodes (OLEDs) at high current densities. Spacial confinement of the triplet excitons, which is mainly dependent on triplet energy differences, can reduce the TTA rate. Therefore, a deliberate choice of the organic semiconductor materials with particular attention to their triplet energies can help to considerably increase the device efficiency. Organic solid-state lasers are, on the other hand, efficiently quenched by singlet–triplet annihilation (STA), which is closely related to the triplet–triplet absorption of the organic semiconductors. To establish a useful set of parameters related to the proc…

Absorption spectroscopyChemistryExcitonAb initio02 engineering and technology010402 general chemistry021001 nanoscience & nanotechnology7. Clean energy01 natural sciences0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsOrganic semiconductorGeneral EnergyChemical physicsComputational chemistryOLEDMoleculePhysical and Theoretical ChemistryTriplet state0210 nano-technologyAbsorption (electromagnetic radiation)The Journal of Physical Chemistry C
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