Search results for "LEVEL"

Why people engage in supplemental work: The role of technology, response expectations, and communication persistence

2021

Supported by various collaboration technologies that allow communication from any place or time, employees increasingly engage in technology-assisted supplemental work (TASW). Challenges associated with managing work and non-work time have been further complicated by a global pandemic that has altered traditional work patterns and locations. To date studies applying a TASW framework have focused mainly on individual uses of technology or connectivity behaviors, and not considered the potential team and social pressures underlying these processes. This study provides clarity on the differences between technology use and TASW and sheds light on the drivers of TASW in a work environment charac…

Gendered power relations in the digital age : an analysis of Japanese women’s media choice and use within a global context

2021

This study investigates the persistence of gendered choice and use of media, particularly in Japanese domestic settings. It shows how women’s significant presence in the digital media environment does not necessarily translate into substantial changes in gendered power dynamics in choosing and using particular media for certain purposes at home. This project’s authors, researchers from Argentina, Finland, Israel, Japan, and the US, analyzed interview data from Japan by drawing on the Foucauldian concept of micro-level power, which is categorized into three main types: personal authority, media affordances, and space-time constellations. Through this process, we interviewed 77 individuals, r…

Urinaryp-cresol is elevated in young French children with autism spectrum disorder: a replication study

2014

The aromatic compound p-cresol (4-methylphenol) has been found elevated in the urines of Italian autistic children up to 8 years of age. The present study aims at replicating these initial findings in an ethnically distinct sample and at extending them by measuring also the three components of urinary p-cresol, namely p-cresylsulfate, p-cresylglucuronate and free p-cresol. Total urinary p-cresol, p-cresylsulfate and p-cresylglucuronate were significantly elevated in 33 French autism spectrum disorder (ASD) cases compared with 33 sex- and age-matched controls (p < 0.05). This increase was limited to ASD children aged ≤8 years (p < 0.01), and not older (p = 0.17). Urinary levels of p-cresol a…

Aquatic ecotoxicology: On the problems of extrapolation from laboratory experiments with individuals and populations to community effects in the field

1991

Abstract 1. 1. Ecotoxicology is defined as the study of the effect of toxicants on structure and function of ecosystems. 2. 2. Properties of individuals and populations in laboratory experiments differ from those in the field with respect to distribution in space and time as well as to genetic structure. 3. 3. Studies of community response can only be extrapolated to other systems if they include the analysis of the causal chain. 4. 4. Causal explanations require a system analysis at different trophic levels as well as a modelling of the system and an analysis of sensitivity. 5. 5. A research project is presented which covers most of the suggested problems.

Acute exposure to 50ppm toluene does not increase sleepiness

2005

Abstract The Pupillographic Sleepiness Test (PST) is a new neurophysiological method to assess sleepiness. In an exposure study to a constant exposure level of 50 ppm toluene on 20 healthy men, our aim was to find out, if increased sleepiness could be seen with PST. PST was performed before and after 4.5 h of exposure. General complaints were assessed with the Swedish Performance Evaluation System (SPES) self-assessment questionnaire, once before and during exposure. Values obtained during exposure were related to pre-exposure values. Parametric cross-over analysis of logarithmic Pupillary Unrest Index (PUI) values did not show an effect of toluene exposure. In a nonparametric cross-over an…

Calidad de la farmacoterapia y seguridad de los pacientes en hemodiálisis tratados con estimulantes eritropoyéticos

2008

Objective: To assess an interdisciplinary programme for the improvement of pharmacotherapy quality and patient safety in patients with chronic renal disease who are treated with erythropoiesis-stimulating agents. Method: Observational, longitudinal study. Retrospective analysis (period A) and prospective analysis (period B) following implementation of the programme for haemoglobin values and monthly erythropoiesis- stimulating agent dosage. The proportion of patients with haemoglobin values within the target range (10-5-12.5 g/dl) and those with values above the safety limit (≥ 12.5g/dl) were compared every four months and the average percentage of time with haemoglobin values within the ta…

2015

BACKGROUND Expensive pharmaceuticals are a major reason for cost intensive health care systems. Long-term immunosuppressive therapy plays a relevant role after organ transplantation. Patents of original drugs have expired and cheaper products are available. Little data are available regarding efficacy and safety of generic immunosuppressive agents. METHODS In this prospective study, 25 patients, who were clinically stable for a minimum of 2 years after liver transplantation, were converted from the original formulations of tacrolimus (TAC) and mycophenolate mofetil to the generics Tacpan (TAP) and Mowel (MOW). Patients were followed-up for 6 months. Results were compared retrospectively to …

La formation en sciences pharmaceutiques, des réformes successives

2019

EnglishIn France, healthcare studies are regulated on a national level. Pharmacy degrees are subjected to numerous decrees and laws setting out the different modifications brought about by successive reforms. The process to adapt this degree course is far from finished. francaisEn France, les etudes de sante sont reglementees au niveau national. La formation pharmaceutique a fait l’objet de nombreux decrets et arretes fixant les differentes modifications induites par les reformes successives

Relationships betweenin vitrodrug dissolution andin vivoresponse

2012

In recent years there has been an effort to relate manufacturing variables to the performance of the dosage form from a clinical point of view (in terms of safety and efficacy). Consequently any control strategy or the establishment of meaningful specifications should take into consideration the clinical impact on the patient. Since plasma levels are considered to be one of the most useful surrogates for clinical safety (in that bioequivalent plasma levels are considered therapeutically equivalent) and dissolution is the best surrogate for bioavailability, it is a natural consequence that dissolution be used to establish the design space in which all the formulations would have similar safe…

Efecto de la administración concomitante de indometacina o ibuprofeno en la farmacocinética de amikacina en neonatos prematuros

2006

Objective: To evaluate whether the concomitant administration of ibuprofen or indomethacin plus amikacin may alter the latter drug's pharmacokinetic parameters, and hence amikacin plasma levels. Method: Retrospective cohort study performed by reviewing the medical records of premature children with persistent ductus arteriosus receiving amikacin and ibuprofen, or amikacin and indomethacin. They were divided up into three groups: group 1: treatment with amikacin went before indomethacin or ibuprofen; group 2: simultaneously treated with amikacin and indomethacin; group 3: simultaneously treated with amikacin and ibuprofen. Pharmacokinetic parameters, distribution volume, and amikacin clearan…