Search results for "LIOP"

Primary ciliary dyskinesia. Ciliopathies

2008

Abstract Primary ciliary dyskinesia is a genetically inherited syndrome characterised by ciliary immotility or dysmotility. Deficiency in mucociliary clearance produces chronic respiratory infections from birth, male sterility by spermatozoid immotility and situs inversus in 40%–50% of patients (Kartagener's syndrome). Diagnosis is made by analysing ciliary motility with high-speed digital video and ciliary ultrastructure. The wide distribution and functions of the cilia in the body mean that this dysfunction can generate other ciliopathies apart from primary ciliary dyskinesia.

Out-of-the-box pelvic surgery including iliopsoas resection for recurrent gynecological malignancies: Does that make sense? A single-institution case…

2017

Abstract Objective To report morbidity and oncological outcomes in a consecutive series of lateral isolated recurrent gynecological cancer involving the pelvic side wall (PSW) including the iliopsoas muscle. Material and methods We retrospectively evaluated a consecutive series between 6/2013 and 12/2015 of lateral isolated recurrent gynecological malignancies treated with a lateral endopelvic resection (LEPR). LEPR was defined as an en-bloc lateral resection of a pelvic tumor with sidewall muscle, and/or bone, and/or major nerve, and/or major vascular structure. Post-surgical complications, quality of life (QoL) and survivals were computed. Results Seventy-four women with pelvic isolated r…

Inhibition of human P450 enzymes by natural extracts used in traditional medicine

2008

Different medicinal plants are widely used in Cuba and Mexico to treat several disorders. This paper reports in vitro inhibitory effects on the P450 system of herbal products commonly used by people in Cuba and Mexico in traditional medicine for decades. Experiments were conducted in human liver microsomes. The catalytic activities of CYP1A1/2, 2D6, and 3A4 were measured using specific probe substrates. The Heliopsis longipes extract exhibited a concentration-dependent inhibition of the three enzymes, and similar effects were produced by affinin (an alkamide isolated from the H. longipes extract) and two catalytically reduced alkamides. Mangifera indica L. and Thalassia testudinum extracts,…

2015

Advanced Astronomy for Heliophysics Plus (ADAHELI+) is a project concept for a small solar and space weather mission with a budget compatible with an European Space Agency (ESA) S-class mission, including launch, and a fast development cycle. ADAHELI+ was submitted to the European Space Agency by a European-wide consortium of solar physics research institutes in response to the "Call for a small mission opportunity for a launch in 2017," of March 9, 2012. The ADAHELI+ project builds on the heritage of the former ADAHELI mission, which had successfully completed its phase-A study under the Italian Space Agency 2007 Small Mission Programme, thus proving the soundness and feasibility of its in…

Testing the ontogenetic base for the transient model of inflorescence development

2013

† Backgrounds and Aims: Current research in plant science has concentrated on revealing ontogenetic processes of key attributes in plant evolution. One recently discussed model is the ‘transient model’ successful in explaining some types of inflorescence architectures based on two main principles: the decline of the so called ‘vegetativeness’ (veg) factor and the transient nature of apical meristems in developing inflorescences. This study examines whether both principles find a concrete ontogenetic correlate in inflorescence development. † Methods: To test the ontogenetic base of veg decline and the transient character of apical meristems the ontogeny of meristematic size in developing inf…

The role of university sports federations in enhancing student sports : a comparative case study between Portugal and Finland

2011

The European Union has increasingly emphasized the sociological, physiological and psychological benefits of sport. Sport provision and participation trends have been measured throughout the member-states and, the gaps between Northern and Southern countries are widely acknowledged. These gaps are especially wide between young-adults and the elderly. The integration of sports into the education curriculum in most European pedagogic systems has resulted in high levels of sport practice among the youth. However as young people enter higher education, member-states face a problem with a natural withdrawal in participation. The universities and student sports federations can plan an important r…

‘World-class’ fantasies : A neocolonial analysis of international branch campuses

2018

In this article, we build on postcolonial studies and discourse analytical research exploring how the ‘world-class’ discourse as an ideology and a fantasy structures neocolonial relations in international branch campuses. We empirically examine how international branch campuses reproduce the fantasy of being so-called world-class operators and how the onsite faculty members identify with or resist this world-class fantasy through mimicry. Our research material originates from fieldwork conducted in business-school international branch campuses operating in the United Arab Emirates. Our findings show the ambivalent nature of mimicry towards the world-class fantasy to include both compliance …

University Teachers’ Professional Identity Work and Emotions in the Context of an Arts-Based Identity Coaching Program

2020

In changing work contexts, there is a critical need to adopt practices that support professional identity work in order to promote individuals’ resilience and well-being at work. This chapter reports on an investigation into professional identity work and emotions in the context of an arts-based coaching program aimed at prompting experienced university teachers to process their professional identities. Since different (un)pleasant emotions emerged during the program, the chapter notably discusses the advantages and pitfalls of using arts-based methods among adults. The findings also contribute to the theoretical understanding of the role of emotions in professional identity processes by re…

Cytotoxicity of 40 Egyptian plant extracts targeting mechanisms of drug-resistant cancer cells

2019

Abstract Background The multidrug resistance (MDR) phenotype encounters a major challenge to the success of established chemotherapy in cancer patients. We hypothesized that cytotoxic medicinal plants with novel phytochemicals can overcome MDR and kill MDR-cells with similar efficacy as drug sensitive cells. Purpose We evaluated plant extracts from an unexplored ecosystem in Egypt with unusual climate and nutrient conditions for their activity against sensitive and multidrug-resistant cancer cell lines. Material and methods/study design Methylene chloride: methanol (1:1) and methanol: H2O (7:3) extracts of 40 plants were prepared resulting in a sum of 76 fraction containing compounds with v…

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

2016

Cellular organelles provide opportunities to relate biological mechanisms to disease. Here we use affinity proteomics, genetics and cell biology to interrogate cilia: poorly understood organelles, where defects cause genetic diseases. Two hundred and seventeen tagged human ciliary proteins create a final landscape of 1,319 proteins, 4,905 interactions and 52 complexes. Reverse tagging, repetition of purifications and statistical analyses, produce a high-resolution network that reveals organelle-specific interactions and complexes not apparent in larger studies, and links vesicle transport, the cytoskeleton, signalling and ubiquitination to ciliary signalling and proteostasis. We observe sub…