Search results for "LIX"
showing 10 items of 891 documents
Electrochemical response of ferrocenium filled calix[4]arene capsules in solution and immobilized on gold
2008
Abstract Hydrogen-bonded dimers of tetra-urea calix[4]arenes are able to include ferrocenium ions as a guest. Heterodimeric capsules are exclusively formed in 1:1 mixtures of tetra-arylurea calix[4]arene 1 with tetra-tosylurea calix[4]arene 2. Sulfide groups attached via spacers on the urea rim of 1 allow their binding to metal surfaces rendering simultaneously their dissociation more difficult. Thus, the electrochemical response of encapsulated ferrocenium could be studied in a self-assembled monolayer (SAM) in addition to the solution electrochemistry with cyclic voltammetry. The stability of the electrochemically active monolayers was tested after a heat treatment (225 °C for 30 min in N…
Biotechnology, Ethics, and Society: The Case of Genetic Manipulation
2015
Biotechnologies are transforming human existence and their potential ever increasing. The discovery of the DNA double helix in 1953 paved the way for genetic medicine and even the possibility to alter the genetic makeup of human beings. Since then, the capacity of the human being to learn about and intervene in his own biological makeup has not ceased to grow.
Dendrochemical assessment of mercury releases from a pond and dredged-sediment landfill impacted by a chlor-alkali plant.
2016
International audience; Although current Hg emissions from industrial activities may be accurately monitored, evidence of past releases to the atmosphere must rely on one or more environmental proxies. We used Hg concentrations in tree cores collected from poplars and willows to investigate the historical changes of Hg emissions from a dredged sediment landfill and compared them to a nearby control location. Our results demonstrated the potential value of using dendrochemistry to record historical Hg emissions from past industrial activities.
Membrane-insertion fragments of Bcl-xL, Bax, and Bid.
2004
Apoptosis regulators of the Bcl-2 family associate with intracellular membranes from mitochondria and the endoplasmic reticulum, where they perform their function. The activity of these proteins is related to the release of apoptogenic factors, sequestered in the mitochondria, to the cytoplasm, probably through the formation of ion and/or protein transport channels. Most of these proteins contain a C-terminal putative transmembrane (TM) fragment and a pair of hydrophobic alpha helices (alpha5-alpha6) similar to the membrane insertion fragments of the ion-channel domain of diphtheria toxin and colicins. Here, we report on the membrane-insertion properties of different segments from antiapopt…
Ruthenium-arene complexes bearing naphthyl-substituted 1,3-dioxoindan-2-carboxamides ligands for G-quadruplex DNA recognition.
2019
Quadruplex nucleic acids – DNA/RNA secondary structures formed in guanine rich sequences – proved to have key roles in the biology of cancers and, as such, in recent years they emerged as promising targets for small molecules. Many reports demonstrated that metal complexes can effectively stabilize quadruplex structures, promoting telomerase inhibition, downregulation of the expression of cancer-related genes and ultimately cancer cell death. Although extensively explored as anticancer agents, studies on the ability of ruthenium arene complexes to interact with quadruplex nucleic acids are surprisingly almost unknown. Herein, we report on the synthesis and characterization of four novel Ru(…
Infections sévères à pyogènes chez les patients traités par infliximab. Étude d’une cohorte régionale
2005
Resume Objectif. – Apprecier la prevalence des infections severes a pyogenes chez les patients traites par infliximab en pratique courante, et essayer de degager des facteurs favorisants. Methodes. – Etude portant sur une cohorte de patients traites dans un reseau regional par infliximab pour polyarthrite rhumatoide ou spondylarthrite ankylosante, et suivis de facon prospective a l’aide d’une feuille de recueil des donnees standardisee. Les observations des patients ayant presente une infection grave a pyogene ont ete analysees, et comparees a celles des autres patients. Resultats. – La cohorte comportait 83 patients (55 femmes et 28 hommes), dont cinq (6 %) ont presente une infection sever…
A novel RNA-binding motif in influenza A virus non-structural protein 1.
1997
The solution NMR structure of the RNA-binding domain from influenza virus non-structural protein 1 exhibits a novel dimeric six-helical protein fold. Distributions of basic residues and conserved salt bridges of dimeric NS1(1-73) suggest that the face containing antiparallel helices 2 and 2′ forms a novel arginine-rich nucleic acid binding motif.
A comparative genetic study on exploited vs. Unperturbed wild populations of Helix Pomatia (L., 1758): preliminary results
2021
Helix pomatia is one of the most well known species of land snails across Europe and it presents economical importance due to its consumption as food. The preliminary results of the genetic comparison between two populations, one of them under the pressure of exploitation, are presented here. As expected, most indices revealed a disequilibrium in the exploited population, with the exeption of the allelic pattern which was similar among the two studied populations.
Girdles as the main infection site for Paradeontacylix kampachi (Sanguinicolidae) in the greater amberjack Seriola dumerili.
2003
In this study, we provide new information about the habitats selected by the blood fluke Paradeontacylix kampachi in the greater amberjack Seriola dumerili based on an exhaustive anatomical examination. From May to October 1998, 21 fish of the 0+ age class were collected from tanks of the Spanish Institute of Oceanography in Puerto de Mazarrón, Spain, for parasitological analysis. Individuals of P. kampachi were found in 17 of the 21 fish analysed (mean intensity +/- SD: 13.6 +/- 16.6; median: 6). Worms occurred in the girdles, cephalic kidney, sinus venosus, kidney and branchial arteries. A Friedman test with a post-hoc contrast revealed a significantly higher number of worms in the girdle…
AB0438 Safety of tnf blockers in case of non-alcoholic fatty liver disease and cirrhosisa systematic review
2018
Background The management of inflammatory rheumatisms and psoriasis has largely evolved over the last 15 years with the emergence of biotherapies whose main adverse effect is the increased infection risk. The prevalence of metabolic syndrome is increasing and has been estimated at 30% in patients with rheumatoid arthritis with an excess of 45% compared to healthy subjects. One of the major complications of the metabolic syndrome is the Non Alcoholic Fatty Liver Disease (NAFLD), which prevalence is 25% in the global population, and 30% in a cohort of patients with rheumatoid arthritis. The main complication of NAFLD is the development of cirrhosis, known to increase infectious risk. Surprisi…