Search results for "LLINs"
showing 10 items of 69 documents
Inhibition of GABA and benzodiazepine receptor binding by penicillins.
1980
Penicillins are thought to be GABA receptor antagonists. In order to determine the affinities of various penicillin derivatives for the GABA receptor, their potencies as inhibitors of specific [3H]GABA binding to rat brain membranes were investigated. All investigated penicillins inhibit specific [3H]GABA binding, with IC50 values ranging from 2 to 60 mM. The results are consistent with the assumption that penicillins are weak GABA receptor antagonists.
Proposed use of spatial mortality assessments as part of the pesticide evaluation scheme for vector control
2013
Background: The WHO Pesticide Evaluation Scheme to evaluate the efficacy of insecticides does not include the testing of a lethal effect at a distance. A tool was developed to evaluate the spatial mortality of an insecticide product against adult mosquitoes at a distance under laboratory and field conditions. Operational implications are discussed. Methods: Insecticide paint, Inesfly 5A IGR (TM), containing two organophosphates (OPs): chlorpyrifos and diazinon, and one insect growth regulator (IGR): pyriproxyfen, was the product tested. Laboratory tests were performed using "distance boxes" with surfaces treated with one layer of control or insecticide paint at a dose of 1 kg/6 sq m. Field …
GIBBERELLINS REGULATE CELL DIVISION AND PARTHENOCARPIC FRUIT SET IN CITRUS
Fruit set and growth is regulated by hormones interaction, gibberellins (GA) being a main part of the process in Citrus. Actually, it is well known the time-course of GA content in the citrus ovary during flowering and its correlation with fruit set in both seeded and seedless species. However, GA endogenous role is uncertain. Is GA in the ovary a direct regulator or an indirect part of the hormonal stimuli that reactivates and maintains cell division triggering fruit set? While in seeded varieties GA synthesis that occurs in fertilized ovules is the primary stimulus controlling early ovary development, is there any specific tissue-dependent regulation of parthenocarpy? While initiation of …
Cerebral toxicity of penicillins in relation to their hydrophobic character
1975
The neurotoxic effects of ticarcillin, methicillin, phenthicillin, oxacillin, cloxacillin and dicloxacillin were studied in the conscious rabbit. During and after intravenous administration of 1.2 and 2.4 g/kg, resp., over 50 min the blood concentrations of the drugs were determined and the neurotoxicity assessed by continuous recording of the electroencephalogram. The hydrophobia of the penicillins was characterized by determination of their partition coefficients between isobutanol and buffer solution pH 7.4. The penicillins showed quite different neurotoxic properties. A close correlation (r = 0.928) was found between the neurotoxic potency of the penicillins and their partition coeffici…
Desmosomes: interconnected calcium-dependent structures of remarkable stability with significant integral membrane protein turnover
2002
Desmosomes are prominent cell adhesion structures that are major stabilizing elements, together with the attached cytoskeletal intermediate filament network, of the cytokeratin type in epithelial tissues. To examine desmosome dynamics in tightly coupled cells and in situations of decreased adhesion, fluorescent desmosomal cadherin desmocollin 2a (Dsc2a) chimeras were stably expressed in human hepatocellular carcinoma-derived PLC cells (clone PDc-13) and in Madin-Darby canine kidney cells (clone MDc-2) for the continuous monitoring of desmosomes in living cells. The hybrid polypeptides integrated specifically and without disturbance into normal-appearing desmosomes that occurred in associati…
Expression Patterns of Key Hormones Related to Pea (Pisum sativum L.) Embryo Physiological Maturity Shift in Response to Accelerated Growth Conditions
2019
Protocols have been proposed for rapid generation turnover of temperate legumes under conditions optimized for day-length, temperature, and light spectra. These conditions act to compress time to flowering and seed development across genotypes. In pea, we have previously demonstrated that embryos do not efficiently germinate without exogenous hormones until physiological maturity is reached at 18 days after pollination (DAP). Sugar metabolism and moisture content have been implicated in the modulation of embryo maturity. However, the role of hormones in regulating seed development is poorly described in legumes. To address this gap, we characterized hormonal profiles (IAA, chlorinated auxin…
Generation of homozygosity and genome fixation in pea (Pisum sativum L.)
2013
Pea cultivars are nearly homozygous and thus homogeneous when they are released. The traditional method of selfing is slow and inefficient, taking up to ten generations of inbreeding following a cross to achieve a high level of homozygosity. Current single-seed-descent (SSD) methodologies enable a maximum of three generations per year to be developed in pea. Doubled haploidy and an in vitro based modified SSD technology have been utilised in many important crops for the rapid achievement of homozygosity, and thus acceleration of the breeding process. In pea, due to the lack of robust protocols, none of these technologies is routinely used in a breeding program. The aim of this study was to …
El potencial cohesionador de les Falles de la Secció Especial 1981-2020 al voltant dels valors conservadors i tradicionals
2021
En aquest treball es planteja "El potencial cohesionador de les falles de la Secció Especial 1981-2020 al voltant de valors conservadors i tradicionals". Aquest estudi mostra com les falles tenen un potencial cohesionador molt elevat i constitueixen un factor de creació d’identitat molt potent. No obstant, es constata que el tradicionalisme i el conservadorisme no son valors únics dintre de la Secció Especial. L’existència de discursos i ideologies alternatives, associades al progressisme, es mostra en una minoria de falles, així com el conservadorisme i el tradicionalisme faller es mostrarien com hegemònics, però no com únics. En aquest estudi és fonamental, ja que es centra en l’element c…
First measurement of the Sivers asymmetry for gluons using SIDIS data
2017
The Sivers function describes the correlation between the transverse spin of a nucleon and the transverse motion of its partons. It was extracted from measurements of the azimuthal asymmetry of hadrons produced in semi-inclusive deep inelastic scattering of leptons off transversely polarised nucleon targets, and it turned out to be non-zero for quarks. In this letter the evaluation of the Sivers asymmetry for gluons in the same process is presented. The analysis method is based on a Monte Carlo simulation that includes three hard processes: photon-gluon fusion, QCD Compton scattering and leading-order virtual-photon absorption process. The Sivers asymmetries of the three processes are simul…
Entrevista a John Sinclair, editor en cap del «Collins Cobuild English Language Dictionary»
2015
Entrevista a John Sinclair, editor en cap del «Collins Cobuild English Language Dictionary»