Search results for "LOAD"
showing 10 items of 1967 documents
Human Amnion-Derived Mesenchymal Stromal Cells: A New Potential Treatment for Carbapenem-Resistant Enterobacterales in Decompensated Cirrhosis
2022
Background: Spontaneous bacterial peritonitis (SBP) is a severe and often fatal infection in patients with decompensated cirrhosis and ascites. The only cure for SBP is antibiotic therapy, but the emerging problem of bacterial resistance requires novel therapeutic strategies. Human amniotic mesenchymal stromal cells (hA-MSCs) possess immunomodulatory and anti-inflammatory properties that can be harnessed as a therapy in such a context. Methods: An in vitro applications of hA-MSCs in ascitic fluid (AF) of cirrhotic patients, subsequently infected with carbapenem-resistant Enterobacterales, was performed. We evaluated the effects of hA-MSCs on bacterial load, innate immunity factors, and macr…
Strategies for annotation and curation of translational databases: the eTUMOUR project
2012
Altres ajuts: LSHC/CT2004-503094 The eTUMOUR (eT) multi-centre project gathered in vivo and ex vivo magnetic resonance (MR) data, as well as transcriptomic and clinical information from brain tumour patients, with the purpose of improving the diagnostic and prognostic evaluation of future patients. In order to carry this out, among other work, a database-the eTDB-was developed. In addition to complex permission rules and software and management quality control (QC), it was necessary to develop anonymization, processing and data visualization tools for the data uploaded. It was also necessary to develop sophisticated curation strategies that involved on one hand, dedicated fields for QC-gene…
On the thermo-mechanical loads and the resultant residual stresses in friction stir processing operations
2008
In friction stir welding and processing both a thermal flux and a mechanical action are exerted on the material determining metallurgical evolutions, changes in the mechanical behaviour and a complex residual stress state. In the paper, the metallurgical changes are examined through numerical simulation and experiments to highlight and distinguish the effects of thermal and mechanical loadings. A particular focus is made on the residual stresses generated during the stir processing of AA7075-T6 aluminium blanks. The predictions of FE model are validated by experimental measurements. Lastly, this paper presents an in-process quenching of the processed blanks for improved mechanical propertie…
Mineralogical and chemical variability of fluvial sediments 2. Suspended-load silt (Ganga–Brahmaputra, Bangladesh)
2011
Sediments carried in suspension represent a fundamental part of fluvial transport. Nonetheless, largely because of technical problems, they have been hitherto widely neglected in provenance studies. In order to determine with maximum possible precision the mineralogy of suspended load collected in vertical profiles from water surface to channel bottom of Rivers Ganga and Brahmaputra, we combined Raman spectroscopy with traditional heavy-mineral and X-ray diffraction analyses, carried out separately on low-density and dense fractions of all significant size classes in each sample (multiple-window approach). Suspended load resulted to be a ternary mixture of dominant silt enriched in phyllosi…
An Open-Label Trial of 12-Week Simeprevir plus Peginterferon/Ribavirin (PR) in Treatment-Naïve Patients with Hepatitis C Virus (HCV) Genotype 1 (GT1)
2016
Background: Shortening duration of peginterferon-based HCV treatment reduces associated burden for patients. Primary objectives of this study were to assess the efficacy against the minimally acceptable response rate 12 weeks post-treatment (SVR12) and safety of simeprevir plus PR in treatment-naïve HCV GT1 patients treated for 12 weeks. Additional objectives included the investigation of potential associations of rapid viral response and baseline factors with SVR12. Methods: In this Phase III, open-label study in treatment-naïve HCV GT1 patients with F0-F2 fibrosis, patients with HCV-RNA 12-week regimen. Conclusions: Overall SVR12 rate (66%) was below the target of 80%, indicating that sho…
Home-based HIV testing: Using different strategies among transgender women in Argentina.
2019
Background In Argentina, HIV prevalence among transgender women (TGW) has been reported at 34%. The stigma is one of the most important factors limiting their access to healthcare services. The aims of this study were to compare different HIV testing methodologies, to determine the factors associated with HIV diagnosis and to determine the feasibility of a home-based HIV testing service for TGW. Methods A multidisciplinary team performed home-based HIV testing interventions in four cities of Argentina. Participants self-identified as TGW, older than 14 years and with a negative or unknown HIV status. Blood samples were screened by two rapid tests (RT), one based on antibodies (Determine™ HI…
Experimental Investigation of the Modal Response of a Rail Span during and after Wheel Passage
2020
This paper examines the vibrations of a rail span (rail section between two consecutive sleepers) during and after the passage of a rail car’s wheel as well as under impact hammer excitation. In literature, the dynamic response of railway tracks under moving loads has been studied extensively. Many of these studies focus on the responses in relation to displacement/force-time histories and wave propagation parameters. These responses are investigated for the time instants when rail car wheels transverse over the rail spans of interest. In this context, an investigation of responses in relation to modal parameters during and after moving loads might provide additional information. Such info…
Radiation and Hydrogen-Loading effects on Raman fiber-based temperature sensors
2013
We present experimental studies on how Raman based temperature sensors undergone two different treatments: gamma-radiation and H-loading. Unfortunately, gamma radiation and hydrogen release in harsh nuclear environment can affect the temperature measurements based on this technology of sensor, limiting the sensor performances. Moreover, the Raman device response in both cases changes with the different classes of multimode fibers that are used by the engineers.
Dynamic Economic Load Dispatch using Levenberg Marquardt Algorithm
2018
Abstract Economic Load Dispatch (ELD) is a very important feature of power system network. This work proposes the novel approach which considers the constraint of ramp rate limit (RRL) to solve the ELD problem. It build up the time varying dynamic economic load dispatch in which load dispatching is calculated for each specified time interval, first it is tested with conventional lambda iteration technique and then the outcomes are used to train artificial neural network (ANN) it is based on Levenberg Marquardt algorithm (LMA).As compared with any other ANN method, the Levenberg Marquardt algorithm based dynamic economic load dispatch is more swift and precise. The propose algorithm is teste…
External training load and the effects on training response following three different training sessions in young elite beach volleyball players
2020
Purpose The interaction between external training load (ETL) and players internal response in beach volleyball is currently poor investigated. Using single parameters (e.g. jump volume) described in indoor settings is questionable due to specific load characteristics like sandy ground and reduced number of players. The aim of this work is to analyze ETL and the effects on training response in different beach volleyball training settings. Methods This study was conducted with 7 youth elite athletes (age: 18.9 ± 1.3 years, height: 185.2 ± 7 cm, body mass: 75.9 ± 10.4 kg, 2 males/5 females). Training sessions were classified into three categories with (A) high session jump volume (SJV) and low…