Search results for "LONG"

Inflammation is an amplifier of lung congestion by high lv filling pressure in hemodialysis patients: a longitudinal study

2019

Introduction Since infammation alters vascular permeability, including vascular permeability in the lung, we hypothesized that it can be an amplifer of lung congestion in a category of patients at high risk for pulmonary oedema like end stage kidney disease (ESKD) patients. Objective and methods We investigated the efect modifcation by systemic infammation (serum CRP) on the relationship between a surrogate of the flling pressure of the LV [left atrial volume indexed to the body surface area (LAVI)] and lung water in a series of 220 ESKD patients. Lung water was quantifed by the number of ultrasound B lines (US-B) on lung US. Six-hundred and three recordings were performed during a 2-year f…

Analysing the mediating role of a network: a Bayesian latent space approach

2020

The use of network analysis for the investigation of social structures has recently seen a rise, due both to the high availability of data and to the numerous insights it can provide into different fields. Most analyses focus on the topological characteristics of networks and the estimation of relationships between the nodes. We adopt a different point of view, by considering the whole network as a random variable conveying the effect of an exposure on a response. This point of view represents a classical mediation setting, where the interest lies in the estimation of the indirect effect, that is, the effect propagated through the mediating variable. We introduce a latent space model mappin…

A model for long-term potentiation and depression

1995

A computational model of long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus is presented. The model assumes the existence of retrograde signals, is in good agreement with several experimental data on LTP, LTD, and their pharmacological manipulations, and shows how a simple kinetic scheme can capture the essential characteristics of the processes involved in LTP and LTD. We propose that LTP and LTD could be two different but conceptually similar processes, induced by the same class of retrograde signals, and maintained by two distinct mechanisms. An interpretation of a number of experiments in terms of the molecular processes involved in LTP and LTD induction and …

NG2 cells: Properties, progeny and origin

2010

The NG2 proteoglycan is a type 1-transmembrane protein expressed by a range of cell types within and outside the mammalian nervous system. NG2-expressing (NG2) cells are found in grey and white matter tracts of the developing and adult CNS and have previously been assumed to represent oligodendrocyte precursor cells: new work using transgenic mice has shown that NG2 cells generate oligodendrocytes, protoplasmic astrocytes and in some instances neurons in vivo. NG2 cells express GABAA receptors and the AMPA subtype of glutamate receptors. They make intimate contact to neurons prior to myelinating axons and also form electron-dense synaptic specialisations with axons in the cerebellum, cortex…

Effects of iontophoretic 5-hydroxytryptamine on the unitary discharge frequency of caudate nucleus neurons in the rat

1980

AbstractSummaryMicroiontophoretic application of 5-hydroxytryptamine (5-HT) on rat caudate nucleus neurons has both facilitatory and inhibitory effects on the discharge frequency of the neurons; in many cases 5-HT has a two-phase action. An analysis was made of the behaviour of facilitatory and inhibitory responses in time considering the mean firing rate variations during and after 5-HT iontophoretic release. Six types of responses have been described : A : short lasting excitation, B : long lasting excitation, C : short lasting inhibition, D : delayed-onset inhibition, E : inhibition followed by excitation, F : excitation followed by inhibition. Also no topographic localization could be m…

The role of N-methyl-D-asparate receptors in neurogenesis.

2006

The dentate gyrus continues to incorporate granule neurons during adulthood. Among the factors that we know modulate adult neurogenesis in the dentate gyrus, one of the first studied was the influence of excitatory amino-acids. These neurotransmitters, acting through NMDA receptors, are able to modulate both the proliferation of progenitor cells as well as the rate of neurogenesis in the adult dentate gyrus. However, the mechanisms by which these processes are influenced are not clearly known. Although there is no anatomical evidence of NMDA receptor expression in adult hippocampal progenitor cells or differentiating granule neurons, electrophysiological data and in vitro studies suggest th…

The next-generation liquid-scintillator neutrino observatory LENA

2012

We propose the liquid-scintillator detector LENA (Low Energy Neutrino Astronomy) as a next-generation neutrino observatory on the scale of 50 kt. The outstanding successes of the Borexino and KamLAND experiments demonstrate the large potential of liquid-scintillator detectors in low-energy neutrino physics. LENA's physics objectives comprise the observation of astrophysical and terrestrial neutrino sources as well as the investigation of neutrino oscillations. In the GeV energy range, the search for proton decay and long-baseline neutrino oscillation experiments complement the low-energy program. Based on the considerable expertise present in European and international research groups, the …

Experiences faced by next of kin during their older family members’ transition into long-term care in a Norwegian nursing home

2013

Aims and objectives To describe and explore experiences of next of kin during the older persons’ transition into long-term care. Background Moving into long-term care is a challenge for both resident and next of kin. Next of kin experience transitions at the same time as they play significant parts in their family members’ transition into long-term care placement. Design Constructivist hermeneutical design. Methods Ten next of kin to newly admitted eight residents were recruited by purposeful sampling and interviewed. Periodic participant observation periods following new residents on arrival day and the first week after admission and some written documentation were the backdrops to the int…

A mass balance evaluation of the ecological significance of historical nitrogen fluxes in Lake Kinneret

2010

Fractional differential calculus for 3D mechanically based non-local elasticity

2011

This paper aims to formulate the three-dimensional (3D) problem of non-local elasticity in terms of fractional differential operators. The non-local continuum is framed in the context of the mechanically based non-local elasticity established by the authors in a previous study; Non-local interactions are expressed in terms of central body forces depending on the relative displacement between non-adjacent volume elements as well as on the product of interacting volumes. The non-local, long-range interactions are assumed to be proportional to a power-law decaying function of the interaction distance. It is shown that, as far as an unbounded domain is considered, the elastic equilibrium proble…