Search results for "LPC"

showing 10 items of 19 documents

Dažādu inhalējamo kortikosteroīdu devu pretiekaisuma darbība un kombinētās terapijas efektivitātes salīdzinājums pacientiem ar vidēji smagu persistēj…

2003

:MEDICINE::Dermatology and venerologyclinical genetics internal medicine::Internal medicine::Lung diseases [Research Subject Categories]Elpceļu iekaisumsAstmaPlaušu slimībasBronhiālās astmas terapijaRespiratory healthMetilksantīniKortikosteroīdiBronhiālā astmaBronchial asthmaAsthmaAntileikotriēni
researchProduct

Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease.

2022

Funder: European Commission

ALTtype 2 diabetes mellitusROC receiving operator characteristicaspartate aminotransferaseHSDLDL low-density lipoproteinUHPLC ultrahigh-performance liquid chromatographyROCHCCNon-alcoholic steatohepatitisGCPCANASHGastroenterology2-HB 2-hydroxybutanoic acid; 3-HB 3-hydroxybutanoic acid; ALT alanine aminotransferase; AST aspartate aminotransferase; CE cholesterol ester; Cer ceramide; FFA free fatty acid; FLIP Fatty Liver Inhibition of Progression; Fibrosis; GC gas chromatography; HCC hepatocellular carcinoma; HSD honest significant difference; LC lipid cluster; LDL low-density lipoprotein; LM lipid and metabolite; LMC lipid metabolite and clinical variable; LPC lysophosphatidylcholine; Lipidomics; Mass spectrometry; Metabolomics; NAFL non-alcoholic fatty liver; NAFLD non-alcoholic fatty liver disease; NAS NASH activity score; NASH non-alcoholic steatohepatitis; NIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research Network; NRR non-rejection rate; Non-alcoholic steatohepatitis; PC(O) ether PC; PC phosphatidylcholine; PCA principal component analysis; PE phosphatidylethanolamine; QTOFMS quadrupole-time-of-flight mass spectrometry; ROC receiving operator characteristic; SAF steatosis activity and fibrosis; SM sphingomyelin; T2DM type 2 diabetes mellitus; TG triacylglycerol; UHPLC ultrahigh-performance liquid chromatographySAFSAF steatosis activity and fibrosisLM lipid and metabolitehonest significant differenceHSD honest significant differenceTG triacylglycerolnon-rejection ratecholesterol esterPCPEGC gas chromatographyfree fatty acidFLIPNASH non-alcoholic steatohepatitisNIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research NetworkBIOMARKERST2DMPE phosphatidylethanolamineLDLlipidNAFLDFFA free fatty acid2-HBMetabolomicsNAFL non-alcoholic fatty liverLMCphosphatidylcholineScience & TechnologySM sphingomyelinGastroenterology & HepatologyMass spectrometryactivitynutritional and metabolic diseasesT2DM type 2 diabetes mellitusACIDSreceiving operator characteristicdigestive system diseasesquadrupole-time-of-flight mass spectrometryLC lipid clusterlow-density lipoproteinNAS2-HB 2-hydroxybutanoic acidNAS NASH activity scoreQTOFMSether PCNRRSCORING SYSTEMprincipal component analysisgas chromatographyLC2-hydroxybutanoic acidPROGRESSIONAST aspartate aminotransferaseLMPC phosphatidylcholinePC(O)MARKERSUHPLCsteatosisTOOLImmunology and AllergyINSULIN-RESISTANCECerSMFatty Liver Inhibition of Progressionhepatocellular carcinoma2-HB 2-hydroxybutanoic acid NIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research Network NRR non-rejection rate Non-alcoholic steatohepatitis PC(O) ether PC PC phosphatidylcholine PCA principal component analysis PE phosphatidylethanolamine QTOFMS quadrupole-time-of-flight mass spectrometry ROC receiving operator characteristic SAF steatosis activity and fibrosis SM T2DM type 2 diabetes mellitus TG triacylglycerol UHPLC ultrahigh-performance liquid chromatographyultrahigh-performance liquid chromatographyCELPC3-HBNAFLnon-alcoholic fatty liverTGtriacylglycerolNRR non-rejection rateLife Sciences & BiomedicineNAFLD non-alcoholic fatty liver diseaseFLIP Fatty Liver Inhibition of Progressionalanine aminotransferasemetaboliteCer ceramideCE cholesterol estersphingomyelinlysophosphatidylcholineand fibrosisALT alanine aminotransferaseInternal MedicineceramideNational Institute of Digestive Diseases and Kidney NASH Clinical Research NetworkAST3-HB 3-hydroxybutanoic acidQTOFMS quadrupole-time-of-flight mass spectrometryPCA principal component analysisLPC lysophosphatidylcholineHepatologynon-alcoholic fatty liver diseaseand clinical variablePC(O) ether PC3-hydroxybutanoic acidFibrosisNASH activity scoreNIDDK NASH-CRNlipid clusterlipid and metabolitephosphatidylethanolamineLipidomicsLMC lipid metabolite and clinical variableFFAHCC hepatocellular carcinomaJHEP reports : innovation in hepatology
researchProduct

Identification of Critical Genes for Growth in Olive Brine by Transposon Mutagenesis of Lactobacillus pentosus C11

2013

ABSTRACT Olive brine represents a stressful environment due to the high NaCl concentration, presence of phenolic compounds known as antimicrobials, and low availability of nutrients. Thus, only a few strains of lactic acid bacteria (LAB) are adapted to grow in and ferment table olives. To identify the mechanisms by which these few strains are able to grow in olive brine, Lactobacillus pentosus C11, a particularly resistant strain isolated from naturally fermented table olives, was mutagenized by random transposition using the P junc -TpaseIS 1223 system (H. Licandro-Seraut, S. Brinster, M. van de Guchte, H. Scornec, E. Maguin, P. Sansonetti, J. F. Cavin, and P. Serror, Appl. Environ. Microb…

DNA Bacterial[SDV.SA]Life Sciences [q-bio]/Agricultural sciencesPROTEIN EXPRESSIONMutantGREEN OLIVESGenetics and Molecular BiologyLactobacillus pentosusSodium ChlorideBINDING PROTEINmedicine.disease_causeApplied Microbiology and BiotechnologyMicrobiology03 medical and health scienceschemistry.chemical_compoundBriningOleaLACTIC-ACBACTERIAmedicineSTRESS-RESPONSE[ SDV.SA ] Life Sciences [q-bio]/Agricultural sciencesEscherichia coliGene Library030304 developmental biology2. Zero hunger0303 health sciencesEcologybiologyReverse Transcriptase Polymerase Chain ReactionSTARTER CULTURE030306 microbiologyPHENOLIC-COMPOUNDSbiology.organism_classificationLactic acidLactobacilluschemistryMutagenesisTABLE OLIVESESCHERICHIA-COLIFermentationDNA Transposable ElementsFood MicrobiologySaltsFermentationTransposon mutagenesisPLANTARUM LPCO10Multiplex Polymerase Chain ReactionBacteriaFood ScienceBiotechnologyApplied and Environmental Microbiology
researchProduct

Tetrazīna fragmentu saturošu linkeru sintēze proteīnu modificēšanai

2022

Maģistra darbā ir veikta jaunu, alifātisku un PEG fragmentus saturošu, tetrazīna linkeru sintēze proteīnu biokonjugācijai. Darba ietvaros iegūti un izolēti 3 linkeri, kas paredzēti neselektīvai Lys aminoskābju atlikumu modificēšanai, un arī iegūti vēl 3 linkeri, kas paredzēti reģiospecifiskai proteīna N-gala modificēšanai. Darba ietvaros arī izolēts viens linkeris, kas paredzēts His modificēšanai. Visi sintezētie linkeri tika testēti modificējot Borrelia Burgdorferi MlpC lipoproteīnu, kā arī veikta paraugu MALDI-TOF MS analīze, kurā no septiņiem linkeriem, seši ir uzrādījuši konjugāta veidošanos ar MlpC.

LINKERIBIOKONJUGĀCIJATETRAZĪNIPROTEĪNSMLPCĶīmija
researchProduct

Stochastical Real Time Finite State Machine LPC for Planar Manipulator Control System Model estimation

2005

This paper presents a new stochastical real-time LPC (Last Principal Component) algorithm to estimate single-input-single-output (SISO) and multiple-input-multiple-output (MIMO) varying time models from input output data clusters of non stationary black boxes. Each of data clusters is on a time window. An application to estimate the control system model of a planar manipulator is developed. In fact many mathematical models of physical systems are non stationary such as industrial manipulator model. A real time estimation algorithm via stochastical LPC algorithm and an appraiser called "finite state machine" is then described For every data cluster the finite state machine updates the parame…

LPCestimationdigital filterfinite state machinemanipulator controlmaximum likelihood
researchProduct

Lipidomic profiling identifies signatures of metabolic risk

2020

Background: Metabolic syndrome (MetS), the clustering of metabolic risk factors, is associated with cardiovascular disease risk. We sought to determine if dysregulation of the lipidome may contribute to metabolic risk factors. Methods: We measured 154 circulating lipid species in 658 participants from the Framingham Heart Study (FHS) using liquid chromatography-tandem mass spectrometry and tested for associations with obesity, dysglycemia, and dyslipidemia. Independent external validation was sought in three independent cohorts. Follow-up data from the FHS were used to test for lipid metabolites associated with longitudinal changes in metabolic risk factors. Results: Thirty-nine lipids were…

Male0301 basic medicineResearch paperdhSL dihydrosphingolipidBMI body mass indexlcsh:MedicineATHEROGENIC LIPOPROTEINSBioinformaticsFHS Framingham Heart StudyPC phosphatidylcholinePESA Progression of Early Subclinical Atherosclerosis0302 clinical medicineFramingham Heart StudyRisk FactorsSAFHS San Antonio Family Heart StudyLC-MS/MS liquid chromatography-tandem mass spectrometryMedicineLongitudinal StudiesMetabolic riskPLASMA SPHINGOLIPID METABOLISMPOPULATIONlcsh:R5-920education.field_of_studySPHINGOMYELINCE cholesteryl esterDysglycemiaGeneral MedicineMiddle AgedLipidomePS phosphatidylserineCardiovascular diseaseLipidsMetabolic syndrome3. Good healthCARDIOVASCULAR-DISEASE030220 oncology & carcinogenesisHEARTMetS metabolic syndromeFemaleDisease SusceptibilityLGPL lysoglycerophospholipidSL sphingolipidlcsh:Medicine (General)LPE lysophosphatidylethanolamineAdultFDR false discovery rateTAG triacylglycerolPopulationCer ceramideCVD cardiovascular diseasePE phosphatidylethanolamineDENSITY-LIPOPROTEINRisk AssessmentGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesAnimalsHumanseducationT2DM type II diabetes mellitusAgedLPC lysophosphatidylcholineSM sphingomyelinbusiness.industryCERAMIDElcsh:RHDL-C High density lipoprotein cholesterolBiomarkerLipid Metabolismmedicine.diseaseObesitySphingolipidCross-Sectional Studies030104 developmental biologyDyslipidemiaERF Erasmus Family StudyLipidomicsMetabolic syndromeINDUCED INSULIN-RESISTANCEbusinessDAG diacylglycerolBody mass indexBiomarkersDyslipidemiaMRM multiple reaction monitoringFASTING GLUCOSE
researchProduct

HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth

2015

International audience; The reduced diameter of skeletal myofibres is a hallmark of several congenital myopathies, yet the underlying cellular and molecular mechanisms remain elusive. In this study, we investigate the role of HACD1/PTPLA, which is involved in the elongation of the very long chain fatty acids, in muscle fibre formation. In humans and dogs, HACD1 deficiency leads to a congenital myopathy with fibre size disproportion associated with a generalized muscle weakness. Through analysis of HACD1-deficient Labradors, Hacd1-knockout mice, and Hacd1-deficient myoblasts, we provide evidence that HACD1 promotes myoblast fusion during muscle development and regeneration. We further demons…

Male[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process EngineeringCellular differentiationGeneralized muscle weaknessBiologyMuscle Developmentcentronuclear myopathyCell LineMyoblasts03 medical and health scienceschemistry.chemical_compoundMyoblast fusionMice0302 clinical medicineDogsVLCFA[SDV.IDA]Life Sciences [q-bio]/Food engineeringGeneticsmedicineMyocyteAnimalsHumans[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process EngineeringMUFACentronuclear myopathyMuscle SkeletalMolecular Biology030304 developmental biologyMice Knockout0303 health sciencesPTPLACell MembraneSkeletal muscleCell DifferentiationCell BiologyGeneral MedicineArticles[SDV.IDA] Life Sciences [q-bio]/Food engineeringmedicine.diseaseCongenital myopathyLysophosphatidylcholinemedicine.anatomical_structureLPCchemistryBiochemistryFemaleProtein Tyrosine Phosphatasescentronuclear myopathy;lpc;mufa;ptpla;vlcfa030217 neurology & neurosurgery
researchProduct

Starpdisciplinārie pētījumi medicīnas koledžās : tēžu krājums

2021

Latvijas Universitātes 79. starptautiskās zinātniskās konferences “Starpdisciplinārie pētījumi medicīnas koledžās” tēzes raksturo medicīnas koledžās veikto pētījumu daudzpusību, pētniecības kvalitāti un arī lietišķumu, kas šogad izceļas ar raksturvārdiem “drošība” un “atbildība”. Konferencē prezentēto un diskutēto jautājumu loks ievērojami pārsniedz veselības aprūpē apskatīto jautājumu loku un veicinās studentus, pētniekus un sociālos partnerus aktīvāk sadarboties ne tikai studiju kvalitātes uzlabošanā, bet arī pētniecībā.

Malnutrīcijapacientu apkope:MEDICINE [Research Subject Categories]urīna nesaturēšanaVecmāšu darbība - vēstureDarba vides risks - sociālā aprūpeErgonomika masu praksēmasāžaKlausīšanās prasme (rehabitaloģija)Marfāna sindroms - aprūpes problēmasTiesu medicīnaKlasiskā kāju masāžaStudiju process- medicīnas koledžaDezinfekcijas līdzekļu efektivitāterehabilitācijaHallux valgusvides riskiAutonomija māsu praksēādas un nagu izmaiņasLipidogrammas rādītājiEelpceļu nodrošināšanaMedikamentozā aprūpe pēcoperācijas periodāHospitālās infekcijasOsteoartrīta pacienta dzīves kvalitātes pašnovērtējumsAntibakteriālo līdzekļu ietošanavīrusu izplatībaMotivācija darbam Neatliekamās medicīniskās palīdzības dienestāRoku mikrofloraRecepšu zāļu izsniegšanaKognitīvie traucējumiAtbalsta un izglītošanas programma nedzirdīgām grūtniecēm
researchProduct

Hroniskas obstruktīvas plaušu slimības (HOPS) molekulārie mehānismi centrālajos un perifērajos elpceļos

2009

Hroniskai obstruktīvai plaušu slimībai (HOPS) ir raksturīga progresējoša un neatgriezeniska plaušu funkciju pasliktināšanās, ko izraisa hroniska elpceļu obstrukcija. Elpceļu obstrukciju novērtē, izmantojot spirometriju. HOPS pašlaik ir ceturtais no biežākajiem mirstības iemesliem Eiropā un ASV, taču tiek prognozēts, ka, smēķētāju skaitam pieaugot, 2020. gadā šī slimība būs jau trešais biežākais nāves cēlonis. Šī darba mērķis bija novērtēt, vai pastāv atšķirības starp iekaisuma procesa mehānismiem centrālajos un perifērajos elpceļos nesmēķētājiem, asimptomātiskiem smēķētājiem un vidēji smagas pakāpes HOPS pacientiem. Darba uzdevumi. Primārais: kvantitatīvi novērtēt iekaisuma šūnu infiltrācij…

Plaušu slimībasPataloģijaMedicineElpceļiPatalogyMedicīna
researchProduct

Epicoccum un Polythrincium sēņu sporas Rīgas gaisā: 2013. un 2014. gada monitoringa rezultāti

2019

Bakalaura darba tēma ir: Epicoccum un Polythrincium sēņu sporas Rīgas gaisā: 2013. un 2014. gada monitoringa rezultāti. Par pētījuma pamatu tika izmantoti aerobioloģiskie un meteoroloģiskie dati 2013. un 2014. gadam. Bakalaura darba mērķis ir noskaidrot Epicoccum un Polythrincium sporu sezonalitāti un diennakts rādītājus Latvijā, un to ietekmējošos faktorus (diennakts gaisa vidējā temperatūra, gaisa relatīvais mitrums, diennakts nokrišņu summa, saules spīdēšanas ilgums utt.). Darba praktiskajā daļā, laboratorijā, tika veikta aerobioloģisko slaidu mikroskopiskā analīze, atpazīstot Epicoccum un Polythrincium sēņu sporas un nosakot to koncentrācijas gaisā. Pēc tam tika veikta sēņu sporu un met…

Polythrincium sēņu sporasVides zinātneAerobioloģijaEpicoccum sēņu sporasElpceļu alerģija
researchProduct