Search results for "LPE"
showing 10 items of 493 documents
Hepatitis C virus antibody secretion in vitro by peripheral blood lymphocytes.
1992
A recombinant polypeptide corresponding to a virus-specific cDNA clone (c100-3) serves as the antigen for a hepatitis C virus (HCV) antibody assay. Previous investigations have shown an 80% prevalence of HCV antibodies in sera of patients suffering from post-transfusional chronic hepatitis non-A, non-B, but positive results were also obtained for 30 to 70% of sera from patients with chronic hepatitis B or autoimmune hepatitis. In this study we show that HCV antibodies are secreted by peripheral blood lymphocytes (PBL) in vitro. PBL from 12/35 patients with chronic non-A, non-B hepatitis and 1/6 patients with chronic active hepatitis B spontaneously secreted HCV antibodies in cell culture su…
Sociālpedagoģiskā darbība homofobijas mazināšanā 10.-12. klasēs.
2022
Par Titas Ļitvinovas diplomdarba tēmu tika izvēlēta “Sociālpedagoģiskā darbība homofobijas mazināšanai 10.-12.klasēs”. Pētījuma mērķis ir raksturot homofobiju un tās izpausmes veidus skolā, kā arī izstrādāt un aprobēt sociālpedagoģisko programmu homofobijas mazināšanā 10.-12.klasēs. Teorētiskajā daļā ir aprakstīts homofobijas vispārējais raksturojums un tās izpausmes, homofobijas vēsturiskais aspekts, homofobija kā vardarbība, atstumtība un diskriminācija un homofobija skolā. Praktiskā daļa sastāv no pētījuma par homofobiju skolā, kā arī tajā ir iekļauta sociālpedagoģiskā darbības programma un tās aprobācija homofobijas mazināšanai vidusskolas klasēs. Sociālpedagoģiskā programma tika izveid…
T helper 1 response is correlated with widespread pain, fatigue, sleeping disorders and the quality of life in patients with fibromyalgia and is modu…
2019
Hyperbaric oxygen therapy (HBOT) has been used as treatment for different clinical conditions, including fibromyalgia (FM). HBOT modulates brain activity, ameliorates chronic pain and modifies the ratio of immune cells. Clinical studies have provided evidence that FM is associated with immune system dysregulation. In the present study we aimed to evaluate the effect of HBOT on immune system and on the quality of life-style of FM patients.Patients with primary FM and controls were treated with HBOT. Physical, emotional and social assessment, quality of sleep, tender points, intensity score, WPI and symptom severity were evaluated before and after HBOT. Furthermore, a characterisation of CD4 …
Kohlschütter-Tönz Syndrome: report of an additional case
2013
Kohlschütter-Tönz Syndrome is a rare disorder clinically characterized by amelogenesis imperfecta, epilepsy and progressive mental deterioration. We present an additional case of this syndrome of a nine year-old boy who was referred by pigmented teeth. The mental deterioration was associated with speech delay, impulsive behavior, attention-deficit/hyperactivity disorder, and learning problems. The physical examination revealed a reduction of lower third, slightly palpebral fissures, low ear and hair implantation, coarse hair and hypertrichosis. The intraoral examination showed alteration in teeth pigmentation diagnosed as amelogenesis imperfecta. Although rare, the present case report illus…
Lymphokine profile and activation pattern of two unrelated antigen- or idiotype-specific T suppressor cell clones.
1992
Two T suppressor (Ts) clones of different specificity have been analyzed for their lymphokine spectrum. BVI/5 is an I-Ek-restricted bovine serum albumin (BSA)-specific Ts cell clone from a CBA/J mouse tolerized by low doses of BSA. It affects directly or indirectly the function of BSA-specific T helper (Th) cells. The Ts cell clone 178-4 from a BALB/c mouse is I-Ed restricted and recognizes the public J558 Id on B cells. It prevents alpha(1----3)dextran B 1355S (Dex)-specific IgG antibody production and drives Dex-specific J558 idiotype-bearing B cells into an anergic B IgG memory cell state. Both Ts cell clones thus cause specific suppression, yet in different experimental systems using di…
Sākumskolas skolēnu ar mācīšanās traucējumiem iekļaušana izglītībā
2021
Artas Zverovas diplomdarbs “Sākumskolas skolēnu ar mācīšanās traucējumiem iekļaušana izglītībā” tika izstrādāts ar mērķi izpētīt skolēnu ar mācīšanās traucējumiem un to iekļaušanu izglītības iestādē. Veikt pētījumu par skolēnu ar mācīšanās traucējumiem iekļaušanu izglītībā. Izstrādāt un aprobēt sociālpedagoģiskās darbības programmu bērniem ar mācīšanās traucējumiem iekļaujošajā izglītībā. Teorētiskajā daļā tika raksturoti mācīšanās traucējumi, iekļaujošā izglītība un atbalsta sistēmas raksturojumi, skolēnu iekļaušanai izglītībā. Prakstiskajā daļā tika veikts pētījums par skolēnu ar mācīšanās traucējumiem iekļaušana izglītības iestādē un izstrādāta sociālpedagoģiskās darbības programma skolē…
Gauskāji (Tardigrada) Rīgas ūdenstilpēs
2019
Gauskāji savu unikālo adaptīvo mehānismu dēļ ir kļuvuši par svarīgu pētāmo objektu vairākās zinātņu nozarēs kā astrobioloģija, hidrobioloģija un medicīna. Tie paver plašāku skatu pētījumos, kas ietver dzīvības iespējas Visumā, vides bioindikācijā, cilvēka veselībā un šūnu rezistencē pret jonizēto starojumu u.c. Bakalaura darba mērķis bija izpētīt pieejamo literatūru – grāmatas un veiktos pētījumus kā pasaulē, tā Latvijas teritorijā par gauskājiem, un apsekot četras, pēc brīvas nejaušības izvēlētas, Rīgas pilsētas ūdenstilpes, ievākt tajās paraugus (rudenī un pavasarī), lai noskaidrotu, vai apsekotajās ūdenstilpēs ir sastopami gauskāji, identificēt sastaptās sugas un spriest pēc iegūtajiem d…
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
2011
Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have ena…
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells.
2010
Summary Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper 2 (Th2) and Th17 cells. Herein, we report that IRF4 is also crucial for the development and function of an interleukin-9 (IL-9)-producing CD4 + T cell subset designated Th9. IRF4-deficient CD4 + T cells failed to develop into IL-9-producing Th9 cells, and IRF4-specific siRNA inhibited IL-9 production in wild-type CD4 + T cells. Chromatin-immunoprecipitation (ChIP) analyses revealed direct IRF4 binding to the Il9 promoter in Th9 cells. In a Th9-dependent asthma model, neutralization of IL-9 substantially ameliorated asthma symptoms. The relevance of these findings is emphasized by the fact that the ind…
Mechanisms underlying lineage commitment and plasticity of human γδ T cells.
2012
Phenotypic and functional heterogeneity are the hallmarks of effector and memory T cells. Upon antigen stimulation, γδ T cells differentiate into two major types of memory T cells: central memory cells, which patrol the blood and secondary lymphoid organs, and effector memory cells, which migrate to peripheral tissues. γδ T cells display in vitro a certain degree of plasticity in their function that is reminiscent of that which is observed in conventional CD4 T cells. Similar to CD4 T cells, in which a plethora of specialized subsets affect the host response, γδ T cells may readily and rapidly assume distinct Th1-, Th2-, Th17-, T(FH) and T regulatory-like effector functions, suggesting that…