Search results for "LPE"
showing 10 items of 493 documents
Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins
2000
After autoimmune inflammation, interactions between CD95 and its ligand (CD95L) mediate thyrocyte destruction in Hashimoto's thyroiditis (HT). Conversely, thyroid autoimmune processes that lead to Graves' disease (GD) result in autoantibody-mediated thyrotropin receptor stimulation without thyrocyte depletion. We found that GD thyrocytes expressed CD95 and CD95L in a similar manner to HT thyrocytes, but did not undergo CD95-induced apoptosis either in vivo or in vitro. This pattern was due to the differential production of TH1 and TH2 cytokines. Interferon gamma promoted caspase up-regulation and CD95-induced apoptosis in HT thyrocytes, whereas interleukin 4 and interleukin 10 protected GD …
The role of regulatory T cell (Treg) subsets in gestational diabetes mellitus.
2014
Physiological changes during normal pregnancy are characterized by an inflammatory immune response and insulin resistance. Therefore, we hypothesize that gestational diabetes mellitus (GDM) may be caused by an inappropriate adaption of the maternal immune system to pregnancy. In this study we examined the role of regulatory T cell (Treg) differentiation for the development of GDM during pregnancy. We used six-colour flow cytometric analysis to demonstrate that the total CD4(+) CD127(low+/-) CD25(+) forkhead box protein 3 (FoxP3(+)) T(reg) pool consists of four different T(reg) subsets: naive CD45RA(+) T(regs), HLA-DR(-) CD45RA(-) memory T(regs) (DR(-) T(regs)) and the highly differentiated …
Is it really useful the Harmonic scalpel in axillary dissection for locally advanced breast cancer? A case series.
2017
Background. The seroma is one of the most common complications in the axillary lymph nodal dissection (different surgical approaches have been tried to reduce the seroma incidence). In our study we evaluate the outcome of patients using or not the ultrasonic scalpel (Harmonic scalpel) according to a standardized surgical technique. Patients and Methods. From January 2011 to December 2015 120 patients underwent axillary dissection for breast cancer. Patients were divided in two groups: patients belonging to the first group underwent Harmonic scalpel dissection and patients belonging to the second group underwent classical dissection. Each group consisted of 60 patients. Quadrantectomy (QUAD)…
Yrttitarhoja ja kasvimaita : kasveja, ihmisiä ja historiaa
2020
Palkittu tietokirja Malva ja mulperi: Poimintoja entisajan puutarhoista esittelee menneisyyden puutarhoja ja pohjustaa monien hyvin tuttujen ja arkistenkin kasvien historiallisia vaiheita aina 1400-luvulta 1800-luvulle saakka. Malva ja mulperi on yleistajuinen ja monipuolisesti ja kauniisti kuvitettu tietokirja, joka pohjaa kasviarkeologi Teija Alangon väitöstutkimukseen. nonPeerReviewed
Trematodes Alaria alata raksturojums dažādās infrapopulācijās Latvijā un ģints analīze, pielietojot molekulārās bioloģijas metodes
2015
Pētījuma mērķis bija noteikt Alaria alata sastopamību dažādās infrapopulācijās Latvijā un veikt ģints filoģenētisko koku analīzi. Pētījuma gaitā tika noteikta A. alata sastopamība meža cūkās (77%), lapsās (88%) un jenotsuņos (84%). Baltijas valstīs ekstensitāte definitīvajos saimniekos ir līdzīga. Salīdzinot divas mezocerkāriju klātbūtnes noteikšanas metodes, tika konstatēts, ka, pielietojot Alaria migrācijas metodi, mezocerkārijus konstatē 10 reizes biežāk salīdzinot ar līdz šim izmantoto metodi. Kā piemērotākais A. alata DNS izdalīšanas reaģentu komplekts tika atzīts DNeasy Blood&Tissue Kit ar palielinātu proteināzes K daudzumu (25μl) un pagarinātu inkubācijas laiku (līdz 15h). Konstruējo…
Data from: Moving in the Anthropocene: global reductions in terrestrial mammalian movements
2019
Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects no…
Presencia de Vulpes praeglacialis (Kormos, 1932) en el yacimiento pleistoceno de la Sierra de Quibas (Abanilla, Murcia)
2006
We describe the first remains of Canidae from the Lower Pleistocene karstic locality of Quibas (Abanillas, Murcia) that increasing the representation of carnivores in this site. These fossils are identified as Vulpes praeglacialis, the typical Lower Pleistocene fox. This assignment is based on their small size and the poorly developed posterior cuspid of the p/3.
Paysage et médiatisation dans les Alpes françaises - Approche géographique de la diffusion des cartes postales paysagères
2010
The usual little holiday ritual, landscape postcards have for first purpose to maintain the social link between people going on holiday and people staying at home. But, by giving a view of a certain area from a different place, those postcards represent an original manner to apprehend touristic places and to answer a seemingly simple question: Why this landscape would be sold on that particular spot ? This theoretical question leads to other questions: Is there a hierarchy among those touristic sites? Would the lack of attractivity of several territories cause their eviction? Would the media coverage of sites have effects upon the destruction of territories ? To answer all those questions, …
IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity
2012
Vγ9Vδ2 T lymphocytes recognize nonpeptidic antigens without presentation by MHC molecules and display pleiotropic features. Here we report that coculture of Vγ9Vδ2 cells with phosphoantigen and IL-21 leads to selective expression of the transcription repressor Bcl-6 and polarization toward a lymphocyte subset displaying features of follicular B-helper T (T(FH)) cells. T(FH) like Vγ9Vδ2 cells have a predominant central memory (CD27(+)CD45RA(-)) phenotype and express ICOS, CD40L and CXCR5. Upon antigen activation, they secrete IL-4, IL-10 and CXCL13, and provide B-cell help for antibody production in vitro. Our findings delineate a subset of human Vγ9Vδ2 lymphocytes, which, upon interaction w…
Requirements for the growth of TH1 lymphocyte clones.
1990
Besides the signal generated in a T lymphocyte after triggering the T cell receptor (TcR), most lymphocytes need a "second signal" to become fully activated. The necessity and nature of the "second signal" differs between different types of T cells. At the level of CD4-positive T helper lymphocytes interleukin 1 (IL 1) serves as "second signal" for those of the TH2 subtype (IL4, 5, 6 producer) but not for those of the TH1 subtype (IL 2, IFN-gamma producer). This correlates with the absence of the IL 1 receptor at the surface of TH1 clones. We report herein the further purification of T cell stimulating factor (TSF), a soluble mediator involved in the proliferation of TH1 lymphocytes. A prep…