Search results for "LR"
showing 10 items of 764 documents
Milrinone is preferred to levosimendan for mesenteric perfusion in hypoxia-reoxygenated newborn piglets treated with dopamine
2012
INTRODUCTION There is little information regarding the comparative hemodynamic effects of adding milrinone or levosimendan to dopamine infusion in hypoxia-reoxygenated (H-R) newborns. RESULTS Severely hypoxic piglets had cardiogenic shock with depressed cardiac index (CI) and mean arterial pressure (MAP). The hemodynamics deteriorated gradually after initial recovery upon reoxygenation. Heart rate and CI improved with milrinone (D+M) and levosimendan (D+L) administration (P < 0.05 vs. control). Both regimens improved carotid arterial flow and carotid vascular resistance; D+M additionally improved superior mesentric arterial flow (all P < 0.05 vs. control). No effect was found on renal arter…
Ressenya a Antonio Cortijo Ocaña (ed.), Chivalry, the Mediterranean, and the Crown of Aragon (2018)
2018

 Ressenya a Antonio Cortijo Ocaña (ed.), Chivalry, the Mediterranean, and the Crown of Aragon, Califòrnia, University of California-Santa Barbara-Juan de la Cuesta Hispanic Monographs- Institució Alfons el Magnànim, 2018, 196 pp., ISBN: 978-1-58871-316-2
 
 Review to Antonio Cortijo Ocaña (ed.), Chivalry, the Mediterranean, and the Crown of Aragon, California, University of California-Santa Barbara-Juan de la Cuesta Hispanic Monographs;-Institució Alfons el Magnànim, 2018, 196 pp., ISBN: 978-1-58871-316-2
Characterization of a new murine retinal cell line (MU-PH1) with glial, progenitor and photoreceptor characteristics
2013
Unlike fish and amphibians, mammals do not regenerate retinal neurons throughout life. However, neurogenic potential may be conserved in adult mammal retina and it is necessary to identify the factors that regulate retinal progenitor cells (RPC) proliferative capacity to scope their therapeutic potential. Müller cells can be progenitors for retinal neuronal cells and can play an essential role in the restoration of visual function after retinal injury. Some members of the Toll-like receptor (TLR) family, TLR2, TLR3 and TLR4, are related to progenitor cells proliferation. Müller cells are important in retinal regeneration and stable cell lines are useful for the study of retinal stem cell bi…
Loss of γ-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis
2008
Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy.
2006
Toll-like receptor 4 (TLR4) is required for efficient recognition of bacterial infections. We investigated an association between 2 TLR4 mutations (Asp 299 Gly and Thr 399 Ile) and meningococcal disease in 197 patients and 214 healthy controls by allele-specific real time polymerase chain reaction and direct sequencing. Although the allele frequency was not higher in the overall patient population, a significantly higher frequency in the 40 patients younger than 12 months of age (P = 0.007) was observed. We conclude that TLR4 mutations represent a risk factor for meningococcal disease in this age group.
Dectin-1 mediatesin vitrophagocytosis ofCandida albicansyeast cells by retinal microglia: Figure 1
2011
We have investigated the expression of TLR2 and Dectin-1 in retinal microglia and their involvement in Candida albicans phagocytosis using a cytometric approach. The expression of both receptors has been demonstrated in CD11b+ retinal cells. Phagocytosis of pHrodo-labelled C. albicans yeasts by microglial CD11b+ cells of C57BL/6 mice was inhibited both by the Dectin-1 antagonist laminarin and anti-Dectin-1 antibodies, whereas phagocytosis of yeasts by retinal microglia of TLR2 KO mice was unaffected. These data indicate that phagocytosis of C. albicans yeasts by retinal microglia is mediated by Dectin-1, whereas TLR2 does not play a significant role in this process.
TLR2: for or against Candida albicans?
2005
In a recent issue of Trends in Microbiology, Netea and coworkers presented their opinion that toll-like receptors (TLRs) are involved in escape from the defense mechanisms of the host [1]. In their article, the authors clearly identified three major TLR-mediated escape mechanisms that are used by microbial pathogens, such as Yersinia, Mycobacterium and Candida. Here, we wish to comment on the roll of TLR2 in Candida albicans infections. Netea's interesting hypothesis, that TLR2 expression might confer to mice an increased susceptibility to C.
About the role of TLR2 and TLR4 in cytokine secretion by murine macrophages in response to Candida albicans.
2006
Dear Editor, In a recent issue of FEMS Immunology and Medical Microbiology , Blasi (2005) studied the biological role of Toll-like receptor (TLR)2 and TLR4 in the effector and secretory responses of murine macrophages to the fungal species Candida albicans . In their article, the authors conclude that the secretory response to C. albicans appears to be TLR4- but not TLR2-dependent. In our opinion this statement is misleading as the results reported do not support this conclusion and, therefore, we wish to comment on this issue. There is evidence indicating that TLR2 is the main receptor involved in triggering cytokine production by murine macrophages in response to C. albicans . Phospholipo…
Polymer-metal plasmonic waveguide : passive and active components for integrated photonics
2009
Dielectric loaded surface plasmon polariton waveguides (DLSPPWs) enable transmission at a sub-wavelength scale of both electrical and plasmonic (optical waves at the interface between a metal and a dielectric) signals in the same circuitry. Moreover, the use of a polymer as the dielectric load enables the functionalization of DLSPPWs. Therefore, this configuration is of great interest for integrated photonic applications. However, DLSPPWs suffer strong losses due to dissipation into the metal film. We address here the possibility of compensating the losses using a configuration analogous to an optical amplifier. We first set theoretical (effective index model), numerical (differential metho…
Streaming for vehicular users via elastic proxy buffer management
2004
In this article we refer to the market of vehicular networks, where groups of customers located in the same public vehicle (e.g., a train or bus) connect to a terrestrial network through a wireless/satellite backbone link. Elastic buffering is a proxy management technique devised to decouple the multimedia information retrieval rate on the network backbone from the playout streaming rate at the user terminal. It has been shown in the past that the application of elastic buffering mechanisms in terrestrial networks brings significant advantages in terms of network effectiveness. We show that elastic buffering is an extremely effective means to reduce, or even eliminate, streaming service out…