Search results for "LR"
showing 10 items of 764 documents
Signaling pathways of the TREM-1- and TLR4-mediated neutrophil oxidative burst.
2008
The triggering receptor expressed on myeloid cells 1 (TREM-1) is involved in the innate inflammatory response to microbial infections. Activation and expression of TREM-1 by polymorphonuclear neutrophils (PMN) occurs in concert with Toll-like receptors (TLR) such as TLR4 for bacterial lipopolysaccharide. However, it is currently unclear how this is mediated on a molecular level. Using pharmacological inhibitors and Western blot analysis we demonstrate that phosphatidyl inositide 3-kinase, phospholipase C and the mitogen-activated kinase p38MAPK are essential for the TREM-1- and TLR4-induced oxidative burst of human PMN. The activation of protein kinase B and extracellular signal-related kin…
The Parkinson Disease Gene LRRK2: Evolutionary and Structural Insights
2006
Mutations in the human leucine-rich repeat kinase 2 (LRRK2) gene are associated with both familial and sporadic Parkinson disease (PD). LRRK2 belongs to a gene family known as Roco. Roco genes encode for large proteins with several protein domains. Particularly, all Roco proteins have a characteristic GTPase domain, named Roc, plus a domain of unknown function called COR. In addition, LRRK2 and several other Roco proteins also contain a protein kinase domain. In this study, I use a combination of phylogenetic and structural analyses of the COR, Roc, and kinase domains present in Roco proteins to describe the origin and evolutionary history of LRRK2. Phylogenetic analyses using these domains…
Kinetics of proton release and uptake by channelrhodopsin-2
2012
Electrophysiological experiments showed that the light-activated cation channel channelrhodopsin-2 (ChR2) pumps protons in the absence of a membrane potential. We determined here the kinetics of transient pH change using a water-soluble pH-indicator. It is shown that ChR2 released protons prior to uptake with a stoichiometry of 0.3 protons per ChR2. Comparison to the photocycle kinetics revealed that proton release and uptake match rise and decay of the View the MathML sourceP3520 intermediate. As the View the MathML sourceP3520 state also represents the conductive state of cation channeling, the concurrence of proton pumping and channel gating implies an intimate mechanistic link of the tw…
Bleomycin Exerts Ambivalent Antitumor Immune Effect by Triggering Both Immunogenic Cell Death and Proliferation of Regulatory T Cells
2013
International audience; Bleomycin (BLM) is an anticancer drug currently used for the treatment of testis cancer and Hodgkin lymphoma. This drug triggers cancer cell death via its capacity to generate radical oxygen species (ROS). However, the putative contribution of anticancer immune responses to the efficacy of BLM has not been evaluated. We make here the observation that BLM induces immunogenic cell death. In particular, BLM is able to induce ROS-mediated reticulum stress and autophagy, which result in the surface exposure of chaperones, including calreticulin and ERp57, and liberation of HMBG1 and ATP. BLM induces anti-tumor immunity which relies on calreticulin, CD8(+) T cells and inte…
Effect of C/N shock variation on the performances of a moving bed membrane bioreactor.
2015
Abstract The effect of a sharp variation of C/N ratio in a moving bed membrane bioreactor (MB-MBR) pilot plant treating high strength wastewater has been investigated. The experimental campaign was divided into two periods, each characterized by a different C/N ratio (namely, 2.5 and 15, Period 1 and Period 2, respectively). The MB-MBR system was analyzed in terms of organic carbon removal, nitrification efficiency, biokinetic activity and fouling behavior. The results showed that the nitrification process was severely affected by lower C/N value and by high concentration of ammonia. It was noticed an extensive stress effect on the autotrophic bacteria. Furthermore, it was observed an incre…
Unificación de enseñanzas relacionadas con el Tratamiento Digital de Señales en la Universitat de València
2011
Teaching Digital Signal Processing (DSP) at the University of Valencia takes place in several subjects with a great overlap in contents. This work proposes an approach to unify DSP contents, so that it is possible to extract the contents corresponding with each subject. Moreover, the proposal is based on a repository that contains the common contents; the repository is hosted on a virtual learning environment, being Moodle and DotLRN the two platforms under study. The final implemented solution consists in an HTMLrepository formed by a number of basic teaching units. These basic units are packaged in a standard IMS-CP format, making up the materials of the different subjects.
Prediction of debris-avalanches and -flows triggered by a tropical storm by using a stochastic approach: An application to the events occurred in Moc…
2019
Abstract Landslides are among the most dangerous natural processes. Debris avalanches and debris flows in particular have often caused casualties and severe damage to infrastructures in a wide range of environments. The assessment of susceptibility to these phenomena may help policy makers in mitigating the associated risk and thus it has attracted special attention in the last decades. In this experiment, we assessed susceptibility to debris-avalanche and -flow landslides by using a stochastic approach. Two different modeling techniques were employed: i) Multivariate Adaptive Regression Splines (MARS) and ii) Logistic Regression (LR). Both MARS and LR allow for calculating the probability …
Evaluation of debris flow susceptibility in El Salvador (CA): a comparison between Multivariate Adaptive Regression Splines (MARS) and Binary Logisti…
2018
In the studies of landslide susceptibility assessment, which have been developed in recent years, statistical methods have increasingly been applied. Among all, the BLR (Binary Logistic Regression) certainly finds a more extensive application while MARS (Multivariate Adaptive Regression Splines), despite the good performance and the innovation of the strategies of analysis, only recently began to be employed as a statistical tool for predicting landslide occurrence. The purpose of this research was to evaluate the predictive performance and identify possible drawbacks of the two statistical techniques mentioned above, focusing in particular on the prediction of debris flows. To this aim, an…
Testing Equality of Multiple Power Spectral Density Matrices
2018
This paper studies the existence of optimal invariant detectors for determining whether P multivariate processes have the same power spectral density. This problem finds application in multiple fields, including physical layer security and cognitive radio. For Gaussian observations, we prove that the optimal invariant detector, i.e., the uniformly most powerful invariant test, does not exist. Additionally, we consider the challenging case of close hypotheses, where we study the existence of the locally most powerful invariant test (LMPIT). The LMPIT is obtained in the closed form only for univariate signals. In the multivariate case, it is shown that the LMPIT does not exist. However, the c…
Locally optimal invariant detector for testing equality of two power spectral densities
2018
This work addresses the problem of determining whether two multivariate random time series have the same power spectral density (PSD), which has applications, for instance, in physical-layer security and cognitive radio. Remarkably, existing detectors for this problem do not usually provide any kind of optimality. Thus, we study here the existence under the Gaussian assumption of optimal invariant detectors for this problem, proving that the uniformly most powerful invariant test (UMPIT) does not exist. Thus, focusing on close hypotheses, we show that the locally most powerful invariant test (LMPIT) only exists for univariate time series. In the multivariate case, we prove that the LMPIT do…