Search results for "LR"
showing 10 items of 764 documents
Zvaigžņotā Debess: 2017, Rudens (237)
2017
Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: U.Dzērvītis. Dispute on Hubble’s Constant Value (abridged) ; E.Mūkins. Ten «Venera»’s: Devices, Journeys and Results (abridged) ; DEVELOPMENTS in SCIENCE: K.Schwartz. New Discoveries in the Orion Molecular Cloud Complex ; SPACE RESEARCH and EXPLORATION: J.Jaunbergs. Salty Emanations of Enceladus ; R.Misa. Voyager: the Longest and Farthest ; OBSERVATORIES and INSTRUMENTS: J.Kuzmanis. Dragon Looks at the Sky ; K.Salmiņš. On ILRS Technical Workshop 2017 in Riga ; CONFERENCES and MEETINGS: M.Sudārs. Trends of Space Infrastructure Development in Europe ; M.Gills. Congress of European Planetary Science 2017 in Riga ; FLASHBACK: N.Cimahoviča. On Whirl…
Zvaigžņotā Debess: 2013, Vasara (220)
2013
Saturs: Pēdējā "Apollo" ekspedīcija uz Mēnesi ; Vissavienības Astronomijas un ģeodēzijas biedrības Latvijas nodaļa ; M.Gills. ESON – astronomijas popularizēšanas tīkls ; S.Kropa. Dvēsele Atakamas tuksnesī ; M.G. Īsumā: ESO Astro Camp Eiropas vidusskolēniem 2013.gada decembrī ; A.Alksnis. Atklāta vēl viena no Saulei vistuvākajām kaimiņzvaigznēm ; A.Alksnis. Tuvēja zvaigzne, kas ir izveidojusies jau drīz pēc Lielā Sprādziena ; A.Alksnis. Čeļabinskas superbolīds – simtgades notikums ; A.Alksnis. Nevis pārsteidzoša nova, bet gan kvazāra uzliesmojums ; I.Eglītis. Orius – Baldones observatorijā atklātais centaurs ; R.Misa. Denisa Tito Marsa iedvesmas fonds ; A.A. Īsumā: Ap zvaigzni Gleznotāja Bet…
Response of Sabella spallanzanii to multiple stressors. The combined effect of infection and copper sulphate
2022
The aim of this work is to study the immune responses of the polychaete Sabella spallanzanii after exposure to copper sulphate, an immunomodulating agent in marine organisms, and the multiple stresses caused by Escherichia coli infection, to validate the species as a model organism in marine-coastal biomonitoring programmes. Polychaetes were housed in laboratory and divided into five experimental groups: 1. Control (no microinjected), 2. filtered seawater + TBS injection (control of point 3), 3. filtered seawater + E. coli injection (control of point 4), 4. CuSO4 + TBS injection (control of point 5), and 5. CuSO4 + E. coli injection. The immune variables, esterase and alkaline phosphatase a…
PCSK9-D374Y mediated LDL-R degradation can be functionally inhibited by EGF-A and truncated EGF-A peptides. An in vitro study
2020
Iedzimtu hiperholesterinēmiju izraisošo mutāciju noskaidrošana Latvijas populācijā
2015
Iedzimta hiperholesterinēmija (IH) ir nopietna ģenētiskā slimība, kurai raksturīgs paaugstināts zema blīvuma lipoproteīnu holesterīna daudzums asinīs. IH ir riska faktors sirds-asinsvadu slimībām. Šīs slimības cēlonis visbiežāk ir mutācijas četros gēnos – LDLR, APOB, PCSK9 un LDLRAP1. Darba mērķis bija noskaidrot IH fenotipu izraisošās mutācijas četros gēnos Latvijas populācijā, izmantojot liela apjoma paralēlās sekvenēšanas metodi. Darbā tika analizētas mutācijas 98 pacientos, kuriem ir aizdomas par IH. Ģenētisko variāciju noteikšanai tika izmantota jaunās paaudzes pusvadītāja sekvenēšanas metode. Rezultātā tika atrastas 97 dažādas nomaiņas, vairums no kurām ir APOB un LDLR gēnos, bet vism…
An international perspective on hospitalized patients with viral community-acquired pneumonia
2019
Background Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. Methods Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. Results 553 (14.9%) patients with CAP underwent nasal swab. Viral CA…
Traditional Chinese herbal medicine at the forefront battle against COVID-19: Clinical experience and scientific basis.
2020
Abstract Background Throughout the 5000-year history of China, more than 300 epidemics were recorded. Traditional Chinese herbal medicine (TCM) has been used effectively to combat each of these epidemics’ infections, and saved many lives. To date, there are hundreds of herbal TCM formulae developed for the purpose of prevention and treatment during epidemic infections. When COVID-19 ravaged the Wuhan district in China in early January 2020, without a deep understanding about the nature of COVID-19, patients admitted to the TCM Hospital in Wuhan were immediately treated with TCM and reported later with >90% efficacy. Approach We conducted conduct a systematic survey of various TCM herbal pre…
Eiropas Savienības un Latvijas Republikas pievienotās vērtības nodokļa normatīvā regulējuma izpēte un pievienotās vērtības nodokļa krāpšanas novēršan…
2020
Viens no svarīgākajiem nodokļiem, gan Latvijā, gan pārējās Eiropas Savienības dalībvalstīs ir pievienotās vērtības nodoklis, kurš būtībā ietekmē jebkuru iedzīvotājs un saimnieciskās darbības veicējs, taču ar šo nodokli tiek veiktas dažādas krāpšanas, kuras veido pievienotās vērtības nodokļa plaisu, kura parāda valsts budžetā neiekasēto pievienotās vērtības nodoklis krāpšanās dēļ. Maģistra darba mērķis ir izpētīt Eiropas Savienības un Latvijas Republikas pievienotās vērtības nodokļa normatīvo regulējumu un pievienotās vērtības nodokļa krāpšanas metodes, lai izstrādātu priekšlikumus nodokļa normatīvā regulējuma pilnveidošanai un krāpšanas novēršanai. Maģistra darba izstrādes rezultātā tika se…
G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson's Disease?
2019
Parkinson’s disease (PD) is the second most common neurodegenerative disorder and has plagued humans for more than 200 years. The etiology and detailed pathogenesis of PD is unclear, but is currently believed to be the result of the interaction between genetic and environmental factors. Studies have found that PD patients with the LRRK2:G2019S variation have the typical clinical manifestations of PD, which may be familial or sporadic, and have age-dependent pathogenic characteristics. Therefore, the LRRK2:G2019S variation may be an ideal model to study the interaction of multiple factors such as genetic, environmental and natural aging factors in PD in the future. This article reviewed the …
Greenberg dysplasia: first reported case with additional non-skeletal malformations and without consanguinity
2001
In 1988 Greenberg et al. reported an association of fetal hydrops with irregular calcification and moth-eaten skeletal dysplasia. Here, we report on the first case of this disorder accompanied by additional malformations (omphalocele, intestinal malrotation, disturbed fingernails and toes, hypolobated lungs) in a German couple without consanguinity (karyotype 46,XY). Sonograpically, the fetus was characterised by tetraphokomelia, severe generalised hydrops, pulmonal hypoplasia and hepato-splenomegaly. Greenberg dysplasia should be considered in differential diagnosis in cases with severe fetal hydrops and phokomelia on antenatal sonography.