Search results for "LSA"
showing 10 items of 832 documents
Adjunctive Brivaracetam in Older Patients with Focal Seizures: Evidence from the BRIVAracetam add‑on First Italian netwoRk Study (BRIVAFIRST).
2022
BACKGROUND: The management of epilepsy in older adults has become part of daily practice because of an aging population. Older patients with epilepsy represent a distinct and more vulnerable clinical group as compared with younger patients, and they are generally under-represented in randomized placebo-controlled trials. Real-world studies can therefore be a useful complement to characterize the drug's profile. Brivaracetam is a rationally developed compound characterized by high-affinity binding to synaptic vesicle protein 2A and approved as adjunctive therapy for focal seizures in adults with epilepsy. OBJECTIVE: The aim of this study was to assess the 12-month effectiveness and tolerabil…
SUCCESSO E DECLINO DELLA SCUOLA GENOVESIANA IN SICILIA SUL FINIRE DEL XVIII E IL PRINCIPIO DEL XIX SECOLO
2021
In the Sicily of late 18th century, during the harshest contraposition between viceroyal government and parliamentary baronage, the Genovesian school gains a great success on the island among scholars and academicians as well as ruling class. In this particular moment of Sicilian history, the theme of reforms is at the top of the political agenda and the thought of Genovesi and his scholars spurs projects to reform the old institutions of the Kingdom, to modernize agriculture, raise productivity and introduce a fairer taxation. The reputation of the Neapolitan school is so well-known that all the parties are inspired by Its economic and political proposals. Furthermore, the Crown and the ba…
An In Vitro Phantom Study on the Role of the Bird-Beak Configuration in Endograft Infolding in the Aortic Arch.
2015
Purpose: To assess endograft infolding for excessive bird-beak configurations in the aortic arch in relation to hemodynamic variables by quantifying device displacement and rotation of oversized stent-grafts deployed in a phantom model. Methods: A patient-specific, compliant, phantom pulsatile flow model was reconstructed from a patient who presented with collapse of a Gore TAG thoracic endoprosthesis. Device infolding was measured under different flow and pressure conditions for 3 protrusion extensions (13, 19, and 24 mm) of the bird-beak configuration resulting from 2 TAG endografts with oversizing of 11% and 45%, respectively. Results: The bird-beak configuration with the greatest protr…
Oedenburg. Une agglomération d’époque romaine sur le Rhin supérieur : fouilles françaises, allemandes et suisses à Biesheim-Kunheim (Haut-Rhin)
2005
Die römische Fundstelle Oedenburg (Biesheim-Kunheim, Haut-Rhin, France) wird seit 1998 von einem international Team ausgegraben (Ecole pratique des hautes études, Paris, Universität Freiburg im Breisgau, Deutschland, Universität Basel, Schweiz). Gegenüber dem keltischen Oppidum von Breisach, nahe am heutigen Rhein gelegen, war die Siedlung in einer deutlich anderen Landschaft angelegt worden, die damals von verschiedenen Flussarmen durchzogen war. Nach dem bisherigen Stand der Erforschung scheint der Ort zu Beginn der tiberischen Zeit von einem Militärlager besetzt gewesen zu sein, das zum Kommandobereich von Vindonissa im Nordteil des Territoriums der Rauriker gehörte. Zur gleichen Zeit en…
Binary neutron star mergers: a jet engine for short gamma-ray bursts
2016
We perform magnetohydrodynamic simulations in full general relativity (GRMHD) of quasi-circular, equal-mass, binary neutron stars that undergo merger. The initial stars are irrotational, $n=1$ polytropes and are magnetized. We explore two types of magnetic-field geometries: one where each star is endowed with a dipole magnetic field extending from the interior into the exterior, as in a pulsar, and the other where the dipole field is initially confined to the interior. In both cases the adopted magnetic fields are initially dynamically unimportant. The merger outcome is a hypermassive neutron star that undergoes delayed collapse to a black hole (spin parameter $a/M_{\rm BH} \sim 0.74$) imme…
All-sky search for continuous gravitational waves from isolated neutron stars using Advanced LIGO O2 data
2019
We present results of an all-sky search for continuous gravitational waves (CWs), which can be produced by fast-spinning neutron stars with an asymmetry around their rotation axis, using data from the second observing run of the Advanced LIGO detectors. We employ three different semi-coherent methods ($\textit{FrequencyHough}$, $\textit{SkyHough}$, and $\textit{Time-Domain $\mathcal{F}$-statistic}$) to search in a gravitational-wave frequency band from 20 to 1922 Hz and a first frequency derivative from $-1\times10^{-8}$ to $2\times10^{-9}$ Hz/s. None of these searches has found clear evidence for a CW signal, so we present upper limits on the gravitational-wave strain amplitude $h_0$ (the …
Evidence that Ultra-High-Energy Gamma Rays are a Universal Feature Near Powerful Pulsars
2021
The highest-energy known gamma-ray sources are all located within 0.5 degrees of extremely powerful pulsars. This raises the question of whether ultra-high-energy (UHE; $>$ 56 TeV) gamma-ray emission is a universal feature expected near pulsars with a high spin-down power. Using four years of data from the High Altitude Water Cherenkov (HAWC) Gamma-Ray Observatory, we present a joint-likelihood analysis of ten extremely powerful pulsars to search for UHE gamma-ray emission correlated with these locations. We report a significant detection ($>$ 3$��$), indicating that UHE gamma-ray emission is a generic feature of powerful pulsars. We discuss the emission mechanisms of the gamma rays a…
Limits on the high-energy gamma and neutrino fluxes from the SGR 1806-20 giant flare of 27 December 2004 with the AMANDA-II detector.
2006
On December 27th 2004, a giant gamma flare from the Soft Gamma-ray Repeater 1806-20 saturated many satellite gamma-ray detectors. This event was by more than two orders of magnitude the brightest cosmic transient ever observed. If the gamma emission extends up to TeV energies with a hard power law energy spectrum, photo-produced muons could be observed in surface and underground arrays. Moreover, high-energy neutrinos could have been produced during the SGR giant flare if there were substantial baryonic outflow from the magnetar. These high-energy neutrinos would have also produced muons in an underground array. AMANDA-II was used to search for downgoing muons indicative of high-energy gamm…
OBSERVATION OF THE TeV GAMMA-RAY SOURCE MGRO J1908+06 WITH ARGO-YBJ
2012
The extended gamma ray source MGRO J1908+06, discovered by the Milagro air shower detector in 2007, has been observed for about 4 years by the ARGO-YBJ experiment at TeV energies, with a statistical significance of 6.2 standard deviations. The peak of the signal is found at a position consistent with the pulsar PSR J1907+0602. Parametrizing the source shape with a two-dimensional Gauss function we estimate an extension \sigma = 0.49 \pm 0.22 degrees, consistent with a previous measurement by the Cherenkov Array H.E.S.S.. The observed energy spectrum is dN/dE = 6.1 \pm 1.4 \times 10^-13 (E/4 TeV)^{-2.54 \pm 0.36} photons cm^-2 s^-1 TeV^-1, in the energy range 1-20 TeV. The measured gamma ray…
XMM-Newton detection of the 2.1 ms coherent pulsations from IGR J17379-3747
2018
We report on the detection of X-ray pulsations at 2.1 ms from the known X-ray burster IGR J17379-3747 using XMM-Newton. The coherent signal shows a clear Doppler modulation from which we estimate an orbital period of ~1.9 hours and a projected semi-major axis of ~8 lt-ms. Taking into account the lack of eclipses (inclination angle of < 75 deg) and assuming a neutron star mass of 1.4 Msun, we estimated a minimum companion star of ~0.06 Msun. Considerations on the probability distribution of the binary inclination angle make less likely the hypothesis of a main-sequence companion star. On the other hand, the close correspondence with the orbital parameters of the accreting millisecond puls…