Search results for "LSA"

Panniculitis due to potassium bromide.

1998

Potassium bromide again is well known to be surprisingly effective in patients with severe myoclonic epilepsy in infants (SME). Rare side effects on the skin reappeared, such as the febrile nodular panniculitis (Weber-Christian syndrome). In 1993 we described the first three cases of necrotizing panniculitis and introduced the term 'halogen panniculitis'. It is a systemic disease with crops of subcutaneous nodules, fever, elevated sedimentation rate, hepatosplenomegalia, and abdominal pain. Later severe necrosis of the skin and adipose tissue may happen with deep ulcerations. History and course of five cases, described in this paper, suggest either an allergy or toxic reason. Histologic pic…

Europa en la Calle

2000

Cardiac output following fetoscopic coagulation of major placental vessels in fetal sheep.

2008

Objectives To measure changes in cardiac output (CO) after partial cord occlusion in fetal sheep in order to investigate pathophysiological fetal adaptation mechanisms in a simulated acute placental insufficiency model under standardized conditions, with the aim of finding relevant methods for monitoring human fetuses during stress situations. Methods We used minimally invasive, percutaneous endoscopic techniques to close umbilical vessels in mid-gestational fetal sheep. Placental blood flow was reduced by preferentially closing first arterial and then the concomitant venous umbilical vessels within a short time interval. The investigations were carried out on 11 pregnant ewes at a median g…

Impact of intra-aortic balloon counterpulsation on all-cause mortality among patients with Takotsubo syndrome complicated by cardiogenic shock: resul…

2023

Abstract Aims Takotsubo syndrome (TTS) is an acute and reversible left ventricular dysfunction and can be complicated by cardiogenic shock (CS). However, few data are available on optimal care in TTS complicated by CS. Aim of this study was to evaluate short- and long-term impact of intra-aortic balloon pumping (IABP) on mortality in this setting. Methods and results In a multi-centre, international registry on TTS, 2248 consecutive patients were enrolled from 38 centres from Germany, Italy, and Spain. Of the 2248 patients, 212 (9.4%) experienced CS. Patients with CS had a higher prevalence of diabetes (27% vs. 19%), male sex (25% vs. 10%), and right ventricular involvement (10% vs. 5%) (P …

Natural Course, Clinical Profile, and Treatment Strategies for Cerebral Cavernous Malformations

2022

A large body of evidence has suggested that the natural biology for symptomatic cerebral cavernous malformations (CCMs) is dynamic. These lesions exhibit a temporal clustering epiphenomenon and usually manifest with multispectral clinical patterns, the most relevant being hemorrhagic and seizurogenic events. Most patients with cerebral cavernous malformations are asymptomatic, and the lesions are detected as incidentalomas. However, association with the CCM3 gene, Zabramski type I and II lesions, and brainstem location have the propensity to increase the bleeding events. The rebleeding risk is 20%/year per lesion, which supports the need for surgical strategies for brainstem cavernous malfo…

Loss of input from the mossy cells blocks maturation of newly generated granule cells.

2007

The objective of this work is to check whether the input from the mossy cells to the inner molecular layer is necessary for the integration and maturation of the newly generated granule cells of the dentate gyrus (DG) in mice, and if after status epilepticus the sprouting of the mossy fibers can substitute for this projection. Newly generated cells were labeled by administration of 5-bromo-deoxyuridine either before or after pilocarpine administration. The neuronal loss in the hippocampus after administration of pilocarpine combined with scopolamine and diazepam seemed restricted to the hilar mossy cells. The maturation of the granule cells was studied using immunohistochemistry for calreti…

La nécropole Néolithique moyen d’Obernai ‘Neuen Brunnen’ (Bas-Rhin) : rites funéraires de la première moitié du 5e millénaire dans le sud de la plain…

2020

The Obernai ’Neuen Brunnen’ necropolis in Lower Alsace yielded 29 tombs attributed to the Middle Neolithic. It was probably founded during the Early Grossgartach, at the end of the 48th century BC, and abandoned during the Roessen, perhaps during the Early Roessen, and in any case before the middle of the 46th century BC. The most original feature of this mortuary assemblage is that most of the tombs belong to the Planig-Friedberg period (the last stylistic phase of the Grossgartach) and the Roessen. The mortuary practices of these periods are still poorly known in the region. The necropolis is composed of three spatial groups, the most ancient of which contains all the Grossgartach tombs a…

Chiese della Kalsa tra XV e XVI secolo

2013

Tra la fine del XV secolo e la prima metà del successivo l’area della Kalsa venne interessata da un sorprendente numero di nuovi cantieri religiosi. Le ragioni di questo frenetico dinamismo costruttivo sono da ricercare innanzitutto nell'attrattiva scaturita dall’area gravitante intorno alla corte viceregia (Steri)e nell’attività di patrocinio devozionale esercitata da aristocratici e mercanti.Sussiste un'interessante, quanto spesso superficialmente trascurata, diversificazione tipologica delle fabbriche religiose (a secondo della loro funzione, della committenza e dell’uso) e a un processo tumultuoso di scarti, di sperimentazioni e di fitto interscambio di esperienze.Sarà bene estendere lo…

Determination of Anticonvulsant Drugs in Pharmaceutical Preparations by Micellar Liquid Chromatography

2004

A micellar liquid chromatographic method for quality control of pharmaceutical preparations (capsules, pills, tablets, injections, drops, and suppositories) containing the anticonvulsant drugs acetazolamide, carbamacepine, chlordiazepoxide, diazepam, ethosuximide, phenytoin, phenobarbital, and zopiclone has been developed. This methodology involves the use of micellar solutions of cetyltrimethylammonium bromide (CTAB) as mobile phases and UV detection. The proposed approach is rapid and reproducible. Sample preparation only requires dissolution with micellar solvent and adequate dilution with the mobile phase before injection into the chromatographic system.

Identification of diterpenes in canvas painting varnishes by gas chromatography-mass spectrometry with combined derivatisation.

2004

A derivatisation method that combines the formation of ethyl esters from the carboxylic groups and trimethylsilyl ethers from hydroxyl groups of the components of diterpenic resins is presented in this paper. This methodology involves two experimental steps: (1) formation of ethyl esters using ethyl chloroformate; and (2) the esterified compounds are lead to react with trimethylsilylimidazole to form the corresponding trimethylsilyl ethers. The main advantage of the proposed method is the possibility of performing simultaneously the analysis of amino acids from proteins, fatty acids from drying oils, and diterpenic compounds from natural resins usually found in works of art. This methodolog…