Search results for "LSA"

A contra-esperanza

2007

Electronic and magnetic properties of VOCl/FeOCl antiferromagnetic heterobilayers

2021

We study the electronic properties of the heterobilayer of vanadium and iron oxychlorides, VOCl and FeOCl, two layered air stable van der Waals insulating oxides with different types of antiferromagnetic order in bulk: VOCl monolayers are ferromagnetic (FM) whereas the FeOCl monolayers are antiferromagnetic (AF). We use density functional theory (DFT) calculations, with Hubbard correction that is found to be needed to describe correctly the insulating nature of these compounds. We compute the magnetic anisotropy and propose a spin model Hamiltonian. Our calculations show that interlayer coupling in weak and ferromagnetic so that magnetic order of the monolayers is preserved in the heterobil…

The inhibitory neural circuitry as target of antiepileptic drugs.

2001

Impairments and defects in the inhibitory neurotransmission in the CNS can contribute to various seizure disorders, i.e., gamma-aminobutyric acid (GABA) and glycine as the main inhibitory neurotransmitters in the brain play a crucial role in some forms of epilepsy. Recent advances in deciphering the molecular basis of the GABAergic and glycinergic systems has been achieved by means of cloning techniques and gene targeting strategies in animals, contributing to the understanding of drug action. As well, several anticonvulsive substances emerged which target key molecules of the inhibitory systems. Employment of recombinant expression systems, including, but not restricted to the inhibitory c…

Effects of GABA-transporter (GAT) inhibitors on rat behaviour in open-field and elevated plus-maze.

1999

The behavioural consequences of inhibition of gamma-aminobutyric acid (GABA) uptake were studied. Two GABA uptake inhibitors, tiagabine and SKF 89976-A, were administered to rats, and behaviour was analysed 30 min later in a standard open field, an enriched open field, and an elevated plus-maze. Eight groups of animals received either saline (0.9%), tiagabine, or SKF 89976-A. At a dose of 18.5 mg/kg, tiagabine, an established antiseizure drug, impaired motor coordination, enhanced exploratory activity and reduced anxiety related behaviour. SKF 89976-A exhibited minimal effects over the dose range tested. These results indicate that inhibition of GABA uptake might be a pharmacological strate…

Dense matter with eXTP

2019

In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry (eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High Energy Physics o…

Does country-level gender equality explain individual risk of intimate partner violence against women? A multilevel analysis of individual heterogene…

2019

Abstract Background Gender equality is widely accepted as an important explanatory factor for the occurrence of intimate partner violence (IPV) against women. However, the relationship is not straightforward, as high country-level gender equality is not always associated with lower IPV prevalence. We apply ‘multilevel analysis of individual heterogeneity and discriminatory accuracy’ (MAIHDA) to (i) quantify the extent to which the country of residence determines individual risk of IPV and (ii) investigate the association between country-level gender equality and individual experience of IPV, and to which extent this association explains the observed between-country differences. Methods Usin…

The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes.

1998

The amino acid gamma-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotransmitter that mediates most of its effects through fast GABA-gated Cl(-)-channels (GABAAR). Molecular biology uncovered the complex subunit architecture of this receptor channel, in which a pentameric assembly derived from five of at least 17 mammalian subunits, grouped in the six classes alpha, beta, gamma, delta, sigma and epsilon, permits a vast number of putative receptor isoforms. The subunit composition of a particular receptor determines the specific effects of allosterical modulators of the GABAARs like benzodiazepines (BZs), barbiturates, steroids, some convulsants, polyvalent cations, and et…

Qualitative remarks on some non-linear aspects of the radio-pulsar magnetosphere

2011

In the class of the submodels SCLF (space-charge limited flow) of the family of "gap-plus-PPF" models, let us exposes some qualitative remarks on the possible turbulent dynamics showed by the zone (II) (see Fig. 1 of the text) of the acceleration zone of the "direct inner gap". Furthermore, we will discuss some consequent physical implications (as, for instance, self-focussing phenomena, Petviashvili's diamagnetism, and so on) concerning structure and physical phenomenology of the remaining subzones (above the subzone (II)) of the given acceleration zone, in connection with possible models for the external solid crust of the radio-pulsar.

Caracterización, Inventariación y aplicación del método de Valoración Biogeográfica de paisajes vegetales (LANBIOEVA) a la comarca de Collsacabra (Gi…

2018

The study presented in this paper takes part of a research project (LANBIOEVA: Landscape Biogeographic Evaluation) carried out for the past 25 years and it is, for now, its last stage. It’s a global landscape valuation method focused on vegetation as a main element of different units that can be evaluated. So far, the use of this method has resulted in numerous works: books, articles, book chapters, communications and presentations, and it has been applied in the study of different temperate and boreal regions of Europe and America. The method has been applied in the study and assessment of diverse vegetation landscapes of the Collsacabra shire (Girona). The objective is to verify its effec…

Work capacity and health-related quality of life among individuals with multiple sclerosis reduced by fatigue: A cross-sectional study

2013

Background: Among individuals diagnosed with the chronic neurologic disease, multiple sclerosis (MS), a majority suffers from fatigue, which strongly influences their every-day-life. The aim of this study was to investigate work capacity and health-related quality of life (HRQoL) in a group of MS patients and also to investigate if work capacity and HRQoL could be predicted by background factors, fatigue, heat sensitivity, cognitive dysfunction, emotional distress or degree of disability. less thanbrgreater than less thanbrgreater thanMethods: A descriptive, cross-sectional, designed survey was undertaken A questionnaire was sent to 323 individuals diagnosed with MS, aged between 20 and 65 …